Postdoctoral position available

[Jenny Hinshaw]

Postdoctoral Position Available
Laboratory of Cell Biochemistry and Biology
National Institute of Health, USA

The focus of the laboratory is to determine if a common mechanism of 
action exists for the diverse dynamin family of proteins.  Dynamin 
family members are large GTPases involved in numerous membrane 
remodeling events in the cell.  Dynamin is crucial for endocytosis, 
synaptic membrane recycling, membrane trafficking within the cell and 
more recently has been associated with filamentous actin.  Other 
dynamin family members are involved in mitochondria division and 
morphology (Drp1, Mgm1), anti-viral activity (Mx, hGBP1), and 
localized to plant cell wall formation and thylakoid membrane 
organization (Phragmoplastin, ADLs). To determine if a common 
mechanism exists among this unique set of proteins, we plan to 
calculate and compare the 3D structure of dynamin family members 
using cryo-electron microscopy and helical reconstruction methods. 
This work will entail purifying and characterizing the dynamin family 
of proteins by combining biochemistry, molecular biology, fluorescent 
and cryo-electron microscopy.

With its diverse laboratories and expertise available on campus, and 
excellent seminars, NIH provides a superb and stimulating scientific 
environment that greatly enhances the postdoctoral training 
experience.  Within our laboratory we have a Philips CM120 electron 
microscope with a cold-stage, as well as all the necessary 
biochemical and molecular biology equipment.  On our floor we have 
direct access to a Zeiss LSM 410 confocal microscope and a CARV 
fluorescent microscope.  We also have access to a state-of-the art 
FEI/Philips CM30 Helium-cooled electron microscope.  In addition, we 
share expertise and scientific discussions daily with several 
established cell biology laboratories working on protein and lipid 
trafficking into the cell and between the cytoplasm and nucleus. 

Contact:  Jenny E. Hinshaw

Laboratory of Cell Biochemistry and Biology
NIDDK, NIH
Building 8, Room 419					phone: +1 301 594 0842
8 Center Dr MSC 0851					fax: +1 301 496 9431
Bethesda, MD 20892, USA				e-mail: jennyh at helix.nih.gov
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_____________________________________________________________________________

Jenny E. Hinshaw				phone:	(301) 594-0842
Laboratory of Cell Biochemistry and Biology	fax: 	(301) 496-9431
Building 8, Room 419, MSC 0851		email: 	jennyh at helix.nih.gov
8 Center Dr.
NIDDK, NIH
Bethesda, MD 20892
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