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--></style><title>Postdoctoral position
available</title></head><body>
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<div><font face="Helvetica" size="+2" color="#000000"><b>Postdoctoral
Position Available<br>
Laboratory of Cell Biochemistry and Biology<br>
National Institute of Health, USA<br>
<br>
</b>The focus of the laboratory is to determine if a common mechanism
of action exists for the diverse dynamin family of proteins.
Dynamin family members are large GTPases involved in numerous membrane
remodeling events in the cell. Dynamin is crucial for
endocytosis, synaptic membrane recycling, membrane trafficking within
the cell and more recently has been associated with filamentous
actin. Other dynamin family members are involved in mitochondria
division and morphology (Drp1, Mgm1), anti-viral activity (Mx, hGBP1),
and localized to plant cell wall formation and thylakoid membrane
organization (Phragmoplastin, ADLs). To determine if a common
mechanism exists among this unique set of proteins, we plan to
calculate and compare the 3D structure of dynamin family members using
cryo-electron microscopy and helical reconstruction methods. This work
will entail purifying and characterizing the dynamin family of
proteins by combining biochemistry, molecular biology, fluorescent and
cryo-electron microscopy.<br>
<br>
With its diverse laboratories and expertise available on campus, and
excellent seminars, NIH provides a superb and stimulating scientific
environment that greatly enhances the postdoctoral training
experience. Within our laboratory we have a Philips CM120
electron microscope with a cold-stage, as well as all the necessary
biochemical and molecular biology equipment. On our floor we
have direct access to a Zeiss LSM 410 confocal microscope and a CARV
fluorescent microscope. We also have access to a state-of-the
art FEI/Philips CM30 Helium-cooled electron microscope. In
addition, we share expertise and scientific discussions daily with
several established cell biology laboratories working on protein and
lipid trafficking into the cell and between the cytoplasm and
nucleus. </font><br>
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<div><font face="Helvetica" size="+2"
color="#000000">Contact: <b> Jenny E. Hinshaw</b></font></div>
<div><font face="Helvetica" size="+2" color="#000000"><br>
Laboratory of Cell Biochemistry and Biology<x-tab>
</x-tab><x-tab> </x-tab><br>
NIDDK, NIH<x-tab>
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</x-tab><x-tab> </x-tab><br>
Building 8, Room 419<x-tab>
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</x-tab><i>phone</i>: +1 301 594 0842<br>
8 Center Dr MSC 0851<x-tab>
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</x-tab><x-tab>
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</x-tab><i>fax</i>: +1 301 496 9431<br>
Bethesda, MD 20892, USA<x-tab>
</x-tab><x-tab>
</x-tab><x-tab>
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</x-tab><i>e-mail</i>:</font><font face="Times" size="+2"
color="#000000"><u> jennyh@helix.nih.gov</u></font></div>
<div>-- <br>
<br>
_____________________________________________________________________<span
></span>________<br>
<br>
Jenny E. Hinshaw<x-tab>
</x-tab><x-tab>
</x-tab><x-tab>
</x-tab><x-tab>
</x-tab>phone:<x-tab> </x-tab>(301) 594-0842<br>
Laboratory of Cell Biochemistry and
Biology<x-tab> </x-tab>fax:
<x-tab> </x-tab>(301) 496-9431<br>
Building 8, Room 419, MSC 0851<x-tab>
</x-tab><x-tab>
</x-tab>email: <x-tab> </x-tab>jennyh@helix.nih.gov<br>
8 Center Dr.<br>
NIDDK, NIH<br>
Bethesda, MD 20892<br>
_____________________________________________________________________<span
></span>__________</div>
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