postdoctoral position at NIH

Jenny Hinshaw jennyh at
Mon Jul 8 17:25:15 PDT 2002

Postdoctoral Position in Cell and Structural Biology Available at the 
National Institute of Health, USA

The structure and function of proteins and macromolecular complexes 
involved in endocytosis, membrane recycling and protein trafficking 
is the focus of the laboratory. At present, we are examining dynamin, 
a protein shown to be essential for receptor-mediated endocytosis, 
synaptic vesicle recycling, and vesicle formation from the 
trans-Golgi network. We are also exploring the role of other members 
of the dynamin family of proteins including the Mx proteins shown to 
be involved in viral infection and a dynamin-like protein (DLP1) that 
has been shown to be involved in mitochondria morphogenesis.  This 
work will entail purifying and characterizing the dynamin family of 
proteins by combining biochemistry, molecular biology, fluorescent 
and cryo-electron microscopy.  For example, using helical 
reconstruction techniques, the candidate may pursue 3-dimensional 
reconstructions of the dynamin mutants to determine the 
conformational change undergone by dynamin that leads to vesiculation 
in endocytosis. 

With its diverse laboratories and expertise available on campus, and 
excellent seminars, NIH provides a superb and stimulating scientific 
environment that greatly enhances the postdoctoral training 
experience.  Within our laboratory we have a Philips CM120 electron 
microscope with a cold-stage, as well as all the necessary 
biochemical (FPLC, Gradifrac) and molecular biology equipment.  On 
our floor we have direct access to a Zeiss LSM 410 confocal 
microscope and a CARV fluorescent microscope.  We also have access to 
a state-of-the art FEI/Philips CM30 Helium-cooled electron microscope 
with resolution capabilities to 1Å.  In addition, we share expertise 
and scientific discussions daily with several established cell 
biology laboratories working on protein and lipid trafficking into 
the cell and between the cytoplasm and nucleus. 

Contact:  Jenny E. Hinshaw, Ph.D

Laboratory of Cell Biochemistry and Biology
Building 8, Room 419					phone: +1 301 594 0842
8 Center Dr MSC 0851					fax: +1 301 496 9431
Bethesda, MD 20892, USA				e-mail: jennyh at


Jenny E. Hinshaw, PhD				phone:	(301) 594-0842
Laboratory of Cell Biochemistry and Biology	fax: 	(301) 496-9431
Building 8, Room 419, MSC 0851			email: 	jennyh at
8 Center Dr.
Bethesda, MD 20892
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