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<div><font face="Helvetica" size="+3" color="#000000"><b>Postdoctoral
Position in Cell and Structural Biology Available at the National
Institute of Health, USA<br>
<br>
</b></font><font face="Helvetica" size="+2" color="#000000">The
structure and function of proteins and macromolecular complexes
involved in endocytosis, membrane recycling and protein trafficking is
the focus of the laboratory. At present, we are examining dynamin, a
protein shown to be essential for receptor-mediated endocytosis,
synaptic vesicle recycling, and vesicle formation from the trans-Golgi
network. We are also exploring the role of other members of the
dynamin family of proteins including the Mx proteins shown to be
involved in viral infection and a dynamin-like protein (DLP1) that has
been shown to be involved in mitochondria morphogenesis. This
work will entail purifying and characterizing the dynamin family of
proteins by combining biochemistry, molecular biology, fluorescent and
cryo-electron microscopy. For example, using helical
reconstruction techniques, the candidate may pursue 3-dimensional
reconstructions of the dynamin mutants to determine the conformational
change undergone by dynamin that leads to vesiculation in
endocytosis. <br>
<br>
With its diverse laboratories and expertise available on campus, and
excellent seminars, NIH provides a superb and stimulating scientific
environment that greatly enhances the postdoctoral training
experience. Within our laboratory we have a Philips CM120
electron microscope with a cold-stage, as well as all the necessary
biochemical (FPLC, Gradifrac) and molecular biology equipment.
On our floor we have direct access to a Zeiss LSM 410 confocal
microscope and a CARV fluorescent microscope. We also have
access to a state-of-the art FEI/Philips CM30 Helium-cooled electron
microscope with resolution capabilities to 1Å. In addition, we
share expertise and scientific discussions daily with several
established cell biology laboratories working on protein and lipid
trafficking into the cell and between the cytoplasm and
nucleus. <br>
<br>
Contact: <b> Jenny E. Hinshaw</b>, Ph.D<br>
http://www.niddk.nih.gov/intram/people/jhinshaw.htm<br>
<br>
Laboratory of Cell Biochemistry and Biology<x-tab>
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NIDDK, NIH<x-tab>
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Building 8, Room 419<x-tab>
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</x-tab><i>phone</i>: +1 301 594 0842<br>
8 Center Dr MSC 0851<x-tab>
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</x-tab><i>fax</i>: +1 301 496 9431<br>
Bethesda, MD 20892, USA<x-tab>
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</x-tab><i>e-mail</i>:</font><font face="Times" size="+2"
color="#000000"><u> jennyh@helix.nih.gov</u></font></div>
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_____________________________________________________________________<span
></span>________<br>
<br>
Jenny E. Hinshaw, PhD<x-tab>
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</x-tab>phone:<x-tab> </x-tab>(301) 594-0842<br>
Laboratory of Cell Biochemistry and
Biology<x-tab> </x-tab>fax:
<x-tab> </x-tab>(301) 496-9431<br>
Building 8, Room 419, MSC 0851<x-tab>
</x-tab><x-tab>
</x-tab><x-tab>
</x-tab>email: <x-tab> </x-tab>jennyh@helix.nih.gov<br>
8 Center Dr.<br>
NIDDK, NIH<br>
Bethesda, MD 20892<br>
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