Post-doctoral and graduate positions in electron microscopy
jtrinick at bmbaxp.leeds.ac.uk
Fri Feb 9 02:50:18 PST 2001
The are two post-doctoral and one post-graduate positions available
in the Muscle Group at Leeds University, UK, each for a period of 3
years. The Leeds Muscle Group specialises in high resolution electron
microscopy and single particle image processing of molecular motors.
We also have expertise in time-resolved cryo-EM.
One post-doctoral position and the PhD studentship both concern the
mechanisms of force production and regulation in myosin molecules.
The aim is to define shape changes, including during interaction with
actin, using wild type and mutant members of the myosin superfamily.
In this work we collaborate with Howard White (Norfolk, VA), Jim
Sellers (NIH, Bethesda) and Joe Chalovitch (Charlottesville).
The other post-doctoral position involves studies of the V-ATPase
rotary motor and is a collaboration with John Findlay and Mike
Harrison at Leeds. Parallel X-ray crystallography and NMR studies on
the V-ATPase subunits are in progress with Simon Philips and Steve
Homans at Leeds.
A background in structural biology will be an advantage and
applicants with skills in mathematics or computing are especially
welcome. In addition to 3 conventional TEMs, state-of-the-art
facilities include a 200kV FEG cryo-EM to be installed in 2001 and a
new Alpha 8CPU cluster with 16GB RAM. Leeds University has one of
the largest and most vigorous groups in structural biology in UK.
The University has 25000 undergraduates and Leeds is a thriving city.
The countryside to the north is outstandingly beautiful
Recent Muscle Group publications include:
1. Walker, M. L., Burgess, S. A., Sellers, J. R., Wang, F., III,
J. A. H., Trinick, J., and Knight, P.
J., Two-headed Binding of a Processive Myosin to F-actin, Nature,
405, 804-807 (2000).
2. Walker, M., Zhang, X. Z., Jiang, W., Trinick, J., and White,
H. D., Observation of transient disorder during myosin subfragment-1
binding to actin by stopped-flow fluorescence and millisecond time
resolution electron cryomicroscopy: Evidence that the start of the
crossbridge power stroke in muscle has variable geometry, Proc. Nat.
Acad. Sci. (USA), 96, 465-470 (1999).
3. White, H. D., Walker, M. L., and Trinick, J., A computer
controlled spray-freezing apparatus for millisecond time-resolution
electron cryo-microscopy., J. Struct. Biol., 121, 306-313 (1998).
4. Burgess, S. A., Walker, M., White, H. D., and Trinick, J.,
Flexibility within Myosin Heads Revealed by Negative Stain and
Single-Particle Analysis., J. Cell Biol., 139, 675-681 (1997).
See http://www.leeds.ac.uk/bms/research/muscle/muscle.htm for more background.
To apply please contact Mrs Debbie Jones, School of Biomedical
Sciences, University of Leeds, LS2 9JT, tel: +44 (0)113 233 4225,
email: d.jones at leeds.ac.uk.
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