[3dem] Cryo-EM staff scientist job @Fischer lab Dana-Farber/Harvard

[Talya Levitz]

 Posting below on behalf of Eric:

Dear 3DEM Community,

I am pleased to share an opening for a cryo-EM Staff Scientist in my laboratory
at Dana-Farber Cancer Institute. We are seeking an experienced
structural biologist
with strong, hands-on expertise in cryo-EM sample preparation, data
acquisition and processing.

https://urldefense.com/v3/__https://careers.dana-farber.org/job/1077/scientist-i-fischer-lab-research-laboratory-us-ma-boston-450-brookline-ave/__;!!Mih3wA!EscgR-9ZUV-u82up0W3Hj0ey4PChkR3gsnrBKGESLp_3G6vzZryROhynp85HdKqm11HHpo_tPAQvVZQfncpY9vpDHyRK$ 

This person will work on various structural biology projects
addressing fundamental
questions in our understanding of the ubiquitin system and ways we can
manipulate this system with molecular glues and degrader molecules for
therapeutic purposes. In addition, you will assist with training and mentoring
Fischer lab members in cryo-EM sample preparation and data processing for
various projects.

*Responsibilities:*
- Independently plan and perform purification strategies for
recombinant proteins
and protein complexes from insect, mammalian or bacterial cells.
- Structure determination by cryo-EM
- Responsible for supporting the needs of multiple small molecule discovery
 projects.
- Responsible for preparing and delivering scientific presentations as
 needed.
- Takes a lead role in the biochemistry, structural biology of projects.
- Train lab members in sample preparation, image acquisition and data
processing
for cryoEM and negative stain.
- Thoroughly documents all experiments, results and findings in a laboratory
notebook.

*Qualifications:*
- PhD degree in biochemistry, structural biology or a related discipline with
at least 2 years of relevant postdoctoral experience.
- Must have experience in experimental and computational cryo-EM techniques.
- Must possess excellent communication and presentation skills.
- Proven track record of publications in peer reviewed journals
reflecting scientific
drive.
- Ability to collect and analyze experimental data, prepare research
publications
and communicate results.
- Demonstrated ability to work in a fast-paced and dynamic environment.
- Ability to work independently as well as in a collaborative and team
environment.
- Strong experience in protein biochemistry, protein purification and
biophysical
characterization.
- Familiarity with biophysical techniques used to assess interactions between
proteins and proteins with small molecules.
- Experience in recombinant protein expression in bacterial, insect
and/or mammalian
cells.
- Experience with purification of recombinant proteins and protein
 complexes.

Best wishes,

Eric

--
Eric S. Fischer, PhD
Joseph Deitch Family Chair & Director, Chemical Biology Program
Dana-Farber Cancer Institute

Professor of Biological Chemistry and Molecular Pharmacology
Harvard Medical School
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