[3dem] [Job] Postdoctoral Positions in Zhang Lab, University of Pittsburgh, School of Medicine, US

[Cheng Zhang]

The Cheng Zhang Lab (https://urldefense.com/v3/__https://www.czhanglab.org/__;!!Mih3wA!BEOjjEj35nvKHYr5tMiBxISTSrzO-NtXub_CGtHjN2XtORP5e6siD-QuzrmyDiMH3VD_Pfej87HjJ0c__G9EWYM$ ) at the University of
Pittsburgh School of Medicine (Pittsburgh, PA, USA) is seeking motivated
postdoctoral researchers to join our NIH- and biotech-funded projects.



Our core research focuses on G protein-coupled receptors (GPCRs). We aim to
elucidate their signaling mechanisms and translate these molecular insights
into novel therapeutic strategies. In our prior research, we have combined
cryo-EM, cell-based signaling assays, and computational modeling and
simulations to study GPCRs activated by neurotransmitters, neuropeptides,
bioactive lipids, and chemokines. Recent publications include *Nature*
(2025, PMID: 40533560), *Science Advances* (2024, PMID: 38198545), *Nature
Communications* (2023, PMID: 37709767; 2022, PMID: 35217703). A full list
of publications can be found at https://urldefense.com/v3/__https://www.czhanglab.org/publications__;!!Mih3wA!BEOjjEj35nvKHYr5tMiBxISTSrzO-NtXub_CGtHjN2XtORP5e6siD-QuzrmyDiMH3VD_Pfej87HjJ0c_lB7rwAI$ .



We are currently expanding our focus to apply these deep structural
insights toward drug discovery and development through collaborations with
experts in computational biology, immunology, and protein engineering.
Current efforts include: 1) identifying novel GPCR modulators with unique
pharmacological properties through structure-based drug design and drug
screening approaches, and 2) developing antibodies targeting orphan GPCRs
and immune-regulatory receptors expressed on macrophages and T cells.



*We welcome applicants with expertise in one or more of the following
areas:*



1. Cryo-EM: Expertise in single particle cryo-EM analysis of membrane
proteins. Our lab has regular access to multiple EM instruments, including
a Titan Krios, at the University of Pittsburgh.



2. GPCR Pharmacology: Experience with cell-based signaling assays (e.g.,
BRET based assays or other high-throughput drug screening assays), or
single-cell imaging and sequencing techniques.



3. Computational Biology: Background in ligand docking, molecular dynamics
(MD) simulations, or protein and antibody design.



*Environment and benefits: *


We offer a collaborative, supportive, and career-focused environment.
Postdocs are encouraged to pursue diverse career paths, including promotion
to research faculty, transition to independent academic positions, or
biotech industry careers through our extensive network of collaborators and
partners. The University of Pittsburgh consistently ranks among the top
NIH-funded institutions in the U.S., and Pittsburgh is frequently
recognized as one of the most livable cities in the country. We support J-1
or H1-b types of visa and can provide support for green card applications
for outstanding postdoctoral researchers.





If you’re passionate about GPCR pharmacology and biology, or novel
approaches in modern drug discovery, we’d love to hear from you. Interested
candidates should apply through the University of Pittsburgh talent center
(position 25005772):
https://urldefense.com/v3/__https://cfopitt.taleo.net/careersection/pitt_faculty_external_pd/jobdetail.ftl?job=25005772&tz=GMT-04*3A00&tzname=America*2FNew_York__;JSU!!Mih3wA!BEOjjEj35nvKHYr5tMiBxISTSrzO-NtXub_CGtHjN2XtORP5e6siD-QuzrmyDiMH3VD_Pfej87HjJ0c_KyfnaJw$ 
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