[3dem] postdoc position, University of Sheffield

[Per A Bullough]

Applications are invited for a BBSRC-funded Research Associate position in
the University of Sheffield. This is a collaborative project jointly
supervised by Prof. Per Bullough and Dr. Rob Fagan (School of Biosciences)
and Prof. Jamie Hobbs (Department of Physics & Astronomy). In this
multidisciplinary project you will join a team applying state-of-the-art
techniques of structural and molecular biology to investigate the way
spores of pathogenic bacteria germinate and their subsequent outgrowth. You
will be based in the Department of Physics and Astronomy under the
supervision of Prof. Hobbs, and liaise with the laboratories of Prof.
Bullough and Dr. Fagan in the adjacent School of Biosciences.

You will have, or be about to obtain, a PhD, with experience of using
atomic force microscopy and/or other microscopy techniques such as CryoEM
or light microscopy to study biological systems from a biophysical
perspective.

Bacteria such as those causing botulism and tetanus survive harsh
conditions and spread disease as spores. However, for these spores to cause
disease they must germinate into so-called vegetative cells. We wish to
understand how this germination takes place and how the active vegetative
cell emerges from the dormant spore. This is a remarkable metamorphosis
where one intricate type of cell structure is completely transformed into a
radically different structure. The process is also interesting because
vegetative cells are much more vulnerable to attack, for example by
antibiotics or disinfectants, than spores are. Thus, if we could work out
how to 'germinate to exterminate', we could develop new weapons against a
number of diseases and food-spoilage organisms. This study builds on recent
advances in the application of AFM to bacteria (Pasquina Lemonche et al,
Nature, 582(7811), 294 (2020)) and bacterial spores (Janganan et al,
mSphere, 5, e00424-20 (2020)).
The University of Sheffield fosters a very collaborative environment for
multidisciplinary work. Sheffield is a lively and friendly city with easy
access to London and other large cities. The city is an excellent base for
outdoor activities, with the Peak District National Park just a few minutes
away from the University.

For further details please contact jamie.hobbs at sheffield.ac.uk or
p.bullough at sheffield.ac.uk.

To apply, visit:

https://urldefense.com/v3/__https://jobs.shef.ac.uk/sap/bc/webdynpro/sap/hrrcf_a_posting_apply?PARAM=cG9zdF9pbnN0X2d1aWQ9NjY4NEJEQjMzQjA1MTkwOUUxMDAwMDAwQUMxRTg4NzgmY2FuZF90eXBlPUVYVA*3d*3d&sap-client=400&sap-language=EN&sap-accessibility=X&sap-ep-themeroot=*2fSAP*2fPUBLIC*2fBC*2fUR*2fuos*__;JSUlJSUlJSM!!Mih3wA!G-ZD7e9IgrXjwbRyTWIbhod6nTGQOo4kAVRbR8Fa1TJdYaaSOfHVVstB-PBz-2WpSI8sO1cIjMHu3aCX6Imt8m02kd9E1Q$ 


Prof. Per A. Bullough
Harrison Chair of Structural Biology
Lead, Molecular Microbiology; Biochemistry to Disease
School of Biosciences
University of Sheffield
Firth Court
Western Bank
Sheffield S10 2TN
United Kingdom

Tel:      +44 (0)114 222 4245
Fax:      +44 (0)114 222 2800
e-mail:   p.bullough at sheffield.ac.uk <p.bullough at sheffield.ac.uk>
https://urldefense.com/v3/__https://www.sheffield.ac.uk/biosciences/research/areas/molecular-microbiology__;!!Mih3wA!G-ZD7e9IgrXjwbRyTWIbhod6nTGQOo4kAVRbR8Fa1TJdYaaSOfHVVstB-PBz-2WpSI8sO1cIjMHu3aCX6Imt8m09NlTq9A$ 
https://urldefense.com/v3/__https://www.sheffield.ac.uk/biosciences/people/academic-staff/bullough__;!!Mih3wA!G-ZD7e9IgrXjwbRyTWIbhod6nTGQOo4kAVRbR8Fa1TJdYaaSOfHVVstB-PBz-2WpSI8sO1cIjMHu3aCX6Imt8m26YV5rHg$ 
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