[3dem] POSTDOCTORAL POSITIONS - MINOR LAB @ UCSF in Ion channel structure and Toxin resistance mechanisms of poison animals

[Minor, Daniel]

MINOR LAB UCSF - Cardiovascular Research Institute

Multiple postdoctoral positions are available immediately for highly motivated individuals with strong backgrounds in biophysics and an interest in structural and chemical biology studies of ion channels or mechanisms of toxin recognition and resistance in the lab of Prof. Dan Minor at the University of California, San Francisco (UCSF). The Minor Lab merges structural, biochemical, chemical biology, genetic, and electrophysiological methods to dissect mechanisms of complex protein machines involved in electrical signaling and to uncover mechanisms of toxin resistance in poison organisms.

1)    Ion channel structure, function, and chemical biology
Projects focus on structural approaches to study ion channel function and development of chemical biology tools for a wide range of channel types. Candidates should have (or expect) an Ph.D. or M.D. and should have demonstrated achievements with X-ray crystallography, cryo‑electronmicroscopy, or electrophysiology.
Ongoing projects focus on mechanisms of voltage-gated, thermosensitive, and mechanosensitive channels and efforts develop new agents to control and image ion channels involved in pain represented by:

Arrigoni, C, Lolicato, M., et al. , ‘Quaternary structure independent folding of voltage-gated ion channel pore domain subunits’  Nature Structural and Molecular Biology  2022 Jun 2. doi: 10.1038/s41594-022-00775-x. Online ahead of print.
Lolicato, M., Natale, A., Abderemane-Ali, F., Crottès, D. Capponi, S., Duman, R., Wagner, A., Rosenberg, J.M., Grabe. M., and Minor, D.L., Jr. ’K2P2.1 channel C-type gating involves asymmetric selectivity filter order-disorder transitions’ Science Advances 6 eabc9174 (2020)
Lolicato, M., Arrigoni, C., Mori, T., Sekioka, Y., Bryant, C., Clark, K.A., Minor, D.L., Jr. ’K2P2.1(TREK‑1):activator complexes reveal a cryptic selectivity filter binding site’ Nature 547 364-368 (2017)
Arrigoni, C., Rohaim, A., Shaya, D., Findeisen ,F., Stein, R.A. Nurva, S.R., Mishra, S., Mchaourab, H.S., and Minor, D.L., Jr., ‘Unfolding of a temperature-sensitive domain controls voltage-gated channel activation’ Cell 164 922-936 (2016) 
2)    Mechanisms of toxin resistance in poison animals
This project focus on using protein engineering and molecular evolution methods to develop new classes of toxin binding proteins. Candidates should have (or expect) an Ph.D. or M.D. and should have demonstrated achievements in protein structure analysis, protein biophysics, or selection methods.
Ongoing projects in this area are represented by:
Yen, T.-J., Lolicato, M., Thomas-Tran, R., Du Bois, J., and Minor, D.L., Jr., 'Structure of the Saxiphilin:saxitoxin (STX) complex reveals a convergent molecular recognition strategy for paralytic toxins' Science Advances 5, eaax2650 (2019)
Abderemane-Ali, F., Rossen, N.D., Kobiela, M.E., Craig, R.A.II, Garrison, C.E., Chen, Z., O'Connell, L.A., Du Bois, J., Dumbacher, J.P., and Minor, D.L., Jr. 'Evidence that toxin resistance in poison birds and frogs is not rooted in sodium channel mutations and relies on ‘toxin sponge’ proteins', J. Gen. Physiol 153:e202112872 (2021) 
More information is available at the lab website http://www.cvri.ucsf.edu/~dminor/ <http://www.cvri.ucsf.edu/~dminor/>
Fellows will benefit from both the outstanding lab environment and the highly collaborative UCSF community.
TO APPLY:
Interested individuals should send a current CV to Prof. Daniel Minor at daniel.minor at ucsf.edu <mailto:daniel.minor at ucsf.edu>




Dan Minor, Ph.D.
Professor
Cardiovascular Research Institute
Departments of Biochemistry & Biophysics,
and Cellular & Molecular Pharmacology
California Institute for Quantitative Biomedical Research
Kavli Institute for Fundamental Neuroscience
University of California, San Francisco


FEDEX/UPS address:

Cardiovascular Research Institute
Box 3122
University of California San Francisco
555 Mission Bay Blvd. South. Rm 452Z
San Francisco, CA 94158-9001

Email: daniel.minor at ucsf.edu
Phone: 415-514-2551
Fax: 415-476-8173
Web: http://www.cvri.ucsf.edu/~dminor
Twitter:http://twitter.com/ElectrosomeUCSF



-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://mail.ncmir.ucsd.edu/pipermail/3dem/attachments/20220605/caf062e0/attachment-0002.html>
-------------- next part --------------
A non-text attachment was scrubbed...
Name: MinorLab_ad_jun22.pdf
Type: application/pdf
Size: 851424 bytes
Desc: not available
URL: <http://mail.ncmir.ucsd.edu/pipermail/3dem/attachments/20220605/caf062e0/attachment-0001.pdf>
-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://mail.ncmir.ucsd.edu/pipermail/3dem/attachments/20220605/caf062e0/attachment-0003.html>
-------------- next part --------------
A non-text attachment was scrubbed...
Name: smime.p7s
Type: application/pkcs7-signature
Size: 1382 bytes
Desc: not available
URL: <http://mail.ncmir.ucsd.edu/pipermail/3dem/attachments/20220605/caf062e0/attachment-0001.p7s>