[3dem] PostDoc position in Electron Tomography at Imperial College London

[Luther, Pradeep K]

We are looking for a highly motivated structural biologist to join our research group studying the fine structure of myosin binding protein C in cardiac muscle and how it is affected by mutations. The sample preparation will involve rapid freezing/freeze substitution for thin section electron microscopy.  Electron tomography and sub-volume averaging will be used to determine the mean structures, essentially following the procedures in our recent paper (Luther et al, 2011, PNAS, 108:11423).  Myosin binding protein C (MyBP-C) is a modular 135 kD protein in striated muscle located at regular intervals along each myosin filament and interacts with actin filaments and myosin S2.  There is great interest in the cardiac isoform as mutations in the corresponding gene lead to heart disease, hypertrophic cardiomyopathy characterised by thickened heart walls.

This post is full-time and fixed-term until 31 December 2016. You should have a PhD in a biological or physical Science subject, or equivalent research, industrial or commercial experience, and should be highly numerate. Experience in electron microscopy and electron tomography of sectioned biological samples and computing with linux is highly desirable.  Strong interest in structural biology is most important.

The project offers the opportunity to work within a well-funded, world class 5* (RAE) department based at Imperial's South Kensington Campus. The electron microscopes to be used for this project include a 200 KV FEI FEG em.

For additional details please contact Dr. Pradeep Luther (p.luther at imperial.ac.uk).  For general details of our research, see our web pages www.sarcomere.org  and http://www1.imperial.ac.uk/nhli/molecular/et/.

The closing date is 10 August 2012.  For application form, please use this link:
https://www4.ad.ic.ac.uk/OA_HTML/OA.jsp?OAFunc=IRC_VIS_VAC_DISPLAY&p_svid=37288&p_spid=1585196

3DEM PIs: I would be much obliged if you could forward this email to potential candidates.


--------------------------------------------------------------------
Pradeep K. Luther
Molecular Medicine Section
National Heart & Lung Institute
Faculty of Medicine
Sir Alexander Fleming Building
Imperial College London
Exhibition Road
London SW7 2AZ

Tel: +44(0)20 7594 3239    Fax: +44(0)20 7594 3119
E: p.luther at imperial.ac.uk   W: www.sarcomere.org<http://www.sarcomere.org/>
--------------------------------------------------------------------


-------------- next part --------------
An HTML attachment was scrubbed...
URL: https://mail.ncmir.ucsd.edu/mailman/private/3dem/attachments/20120726/5ccb55d6/attachment.html