[3dem] fiducial markers for cryoTEM
Frank Polzer
frank.polzer at physik.hu-berlin.de
Wed Feb 22 03:49:29 PST 2012
Dear all,
Does anyone know a good alternative for fiducial markers if gold fiducials
(e.g., Aurion Gold Sol, 10 nm) heavily adsorbs to the sample. In this case,
I have synthetic block-co-polymer micelles (in water) which exhibits a
quaternized 2-vinylpyridine groups, so that the gold fiducial markers are
strongly correlated within the micellar structure (I expect due to the
positive charge of the quaternized 2-vinylpyridine) and almost no gold
nanoparticles can be found apart from the sample within the vitreous film.
Thank you all in advance for your help!
Kind regards,
Frank
Frank Polzer
TEM Group
Institute of Physics
Humboldt Universität zu Berlin
Newtonstraße 15
12489 - Berlin
Tel.: +49 30 2093-7905 (office)
Tel.: +49 30 2093-7829 (TEM)
Fax: +49 30 2093-7760
frank.polzer at physik.hu-berlin.de
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