[3dem] Postdoctoral Position in Single Particle Studies of the
Nuclear Pore Complex
David Stokes
stokes at nyu.edu
Thu Jul 22 15:26:45 PDT 2010
Postdoctoral Position in Single Particle Studies of the Nuclear Pore Complex
A postdoctoral position is open at the New York Structural Biology
Center (NYSBC) to study macromolecular assemblies forming part of the
nuclear pore complex. These studies are part of the National Center for
Dynamic Interactome Research (NCDIR) a transcontinental effort on
bioinformatics to elucidate form and function of biologically important
organelles, using a combination of biochemical data, mass spectrometry,
X-ray crystallography, nuclear magnetic resonance and electron
microscopy (http://www.ncdir.org). In addition to staff at NYSBC (Ruben
Diaz), this collaboration includes laboratories at Rockefeller
University (Michael Rout and Brian Chait), Institute for Systems
Biology, Seattle (John Aitchison) and University of California, San
Francisco (Andrej Sali).
At NYSBC, we aim to characterize the macromolecular assemblies by single
particle electron microscopy. The assemblies tend to be small and
available in small quantities, but even 2D class averages are proving
valuable as holonomic constraints in the force fields used for modeling
the structure of the entire nuclear pore complex. In favorable cases, 3D
reconstructions will be conducted using random conical tilt methods.
Preference will be given to candidates familiar with single particle
analysis and with a strong interest in the experimental aspects of
electron microscopy. The position is funded for a period of 5 years and
will be based at the New York Structural Biology Center, which is a
state of the art cryo-electron microscopy facility located on the island
of Manhattan (http://cryoem.nysbc.org). Please send application
materials to David Stokes (stokes at nysbc.org) with a CV and the names of
three references.
--
David L. Stokes
Skirball Institute, NYU Medical Center
tel: 212-263-1580
http://saturn.med.nyu.edu/~stokes
----
New York Structural Biology Center
tel: 212-939-0660 x9116
http://nysbc.org/
fax: 646-219-0300
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