Job openings at the NCMI
Steven Ludtke
stevel at tiger.3dem.bioch.bcm.tmc.edu
Wed Sep 20 09:58:23 PDT 2000
We would like to announce the availability of several positions at the
National Center for Macromolecular Imaging (NCMI) at Baylor College
of Medicine, Houston, TX (http://ncmi.bcm.tmc.edu). The NCMI is
devoted to 3D reconstructions of molecules/macromolecules using electron cryo-microscopy
and a variety of computational techniques. The Center is well
equipped, with several high resolution electron cryomicroscopes, a
32 processor SGI supercomputer and a 32 processor linux cluster. We are
seeking applicants with a variety of skills for several ongoing projects.
The NCMI recently published a structure of the herpesvirus capsid
structure to ~8 angstrom resolution (Zhou et al., Science, 288:877-880,
2000). This is an extremely large particle with computer processing
requirements which push the capabilities of currently available
supercomputers. We are seeking a candidate who will aggressively pursue
the goal of improving the resolution of this reconstruction. Much
data has already been collected, but novel approaches towards
reconstruction may need to be devised to achieve the desired
resolution. This is a high-impact project which offers exciting
opportunties for a motivated researcher.
The NCMI is currently designing a database for use in EM project
management. The higher resolution structures now being generated in
electron cryomicroscopy require large amounts of data. A single project
currently has on the order of 100,000 particles, collected from dozens to
hundreds of micrographs collected over many weeks or months. Book-keeping
on such large data sets is a difficult task. The database project will
assist in keeping track of the data from biochemical purification all the
way through final 3D model. We are seeking applicants for this, to work on
design and implementation of this, and related database projects at the
NCMI.
The NCMI recently published EMAN
(http://ncmi.bcm.tmc.edu/~stevel/EMAN/doc), a complete software package
for performing 3D reconstructions using single particle processing
techniques (Ludtke et al, J. Structural Biology 128: 82-97, 1999). This
package is under continued development, and is currently being used
in-house on nearly a dozen different projects. We are seeking applicants
both to work on software/algorithm development for EMAN, and to apply it
to real biological applications.
We are seeking several candidates at any level for these positions. The exact
nature of the position will be determined by the qualifications and
interests of the successful applicant. Applications will be accepted from
both academic postdocs and professional/scientific programmers. Some
of the skills we are looking for (in any combination) are:
EM experience (any type)
Image processing
Background in biochemistry, physics, EE or CS.
Scientific programming involving FFT's and/or wavelets
Database programming experience
Numerical Analysis
Signal Processing
Java/C++
Postgres
Unix/Linux
The NCMI is part of the Biochemistry and Molecular Biology
department at Baylor College of Medicine (http://www.bcm.tmc.edu),
located in the Texas Medical Center in Houston, TX. This is one of the
largest concentrations of hospitals and bio-medical institutions in the
world. The NCMI has several on-going collabortaions with
computational scientists through our assoication with the W. M. Keck
Center for Computational Biology (http://www-bioc.rice.edu/ ) and
the Graduate Program in Structural and Computational Biology and
Molecular Biophysics (http://www.bcm.tmc.edu/scbmb/). NCMI is also a
partner of the NPACI of the UCSD Supercomputer Center
(http://www.npaci.edu/).
Interested individuals should send a CV/resume and two letters of
reference to:
Dr. Steven Ludtke (sludtke at bcm.tmc.edu) or Dr. Wah Chiu (wah at bcm.tmc.edu)
Biochemistry & Molecular Biology
Baylor College of Medicine
Houston, TX 77030
Feel free to email any questions you may have about the positions.
--
----------------------------------------------------------------------------
Dr. Steven Ludtke | Baylor College of Medicine
sludtke at bcm.tmc.edu | National Center For Macromolecular Imaging
stevel at alumni.caltech.edu | * Those who do ARE *
http://ncmi.bcm.tmc.edu/~stevel | The converse also holds
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