<html>
<head>
<meta http-equiv="Content-Type" content="text/html; charset=iso-8859-1">
<style type="text/css" style="display:none;"> P {margin-top:0;margin-bottom:0;} </style>
</head>
<body dir="ltr">
<div style="text-align: left; text-indent: 0px; margin-top: 1em; margin-bottom: 1em; font-family: Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);" class="elementToProof">
Hello everyone,</div>
<div style="text-align: left; text-indent: 0px; margin-top: 1em; margin-bottom: 1em; font-family: Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);" class="elementToProof">
We would like to invite you to explore how Cryo-EM transforms challenging targets into structural insights. In this case study, we showcase the journey of CYP3A4, from gene to structure, highlighting key steps in protein preparation, sample optimization, and
data collection. This work shows how we managed the oligomeric complexity of CYP3A4, a key enzyme in drug metabolism and toxicology, and uncover new structural features.</div>
<div style="text-align: left; text-indent: 0px; margin-top: 1em; margin-bottom: 1em; font-family: Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);" class="elementToProof">
Join us to see how Cryo-EM success is built, one structure at a time.</div>
<div style="text-align: left; text-indent: 0px; margin-top: 1em; margin-bottom: 1em; font-family: Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);" class="elementToProof">
Registration link:</div>
<div style="font-family: Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);" class="elementToProof">
<a class="OWAAutoLink" id="LPlnk135819" href="https://urldefense.com/v3/__https://nimgs.zoom.us/webinar/register/4017564810214/WN_JsgAhOxgTs2fnyxwD1mTGA__;!!Mih3wA!GztVXv4rtF_Flns6rvEv0UaEcFIvQ-DVcsnewodhUUBOSmIS8oUN8FTphQfxbg36nHcjp6sOd-2WBAO9tqCehySD2Y-yf3k$">https://nimgs.zoom.us/webinar/register/4017564810214/WN_JsgAhOxgTs2fnyxwD1mTGA</a></div>
<div style="font-family: Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);" class="elementToProof">
<br>
</div>
<div style="font-family: Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);" class="elementToProof">
<b>"Soluble Proteins in Focus: Preparing for Cryo-EM Success</b></div>
<div style="font-family: Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);" class="elementToProof">
<br>
Join NanoImaging Services, to get expert advice on how to set your project up for success. He will walk through each stage from protein production to structure determination, highlighting practical insights and lessons from a recent case study on CYP3A4, a
57 kDa cytochrome P450 monooxygenase that was solved to 3.1 Å."</div>
<div style="font-family: Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);" class="elementToProof">
<br>
Best,</div>
<div class="elementToProof" id="Signature">
<div style="font-family: Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);" class="elementToProof">
<br>
</div>
<div style="font-family: Aptos, Aptos_EmbeddedFont, Aptos_MSFontService, Calibri, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);" class="elementToProof">
Claudio Catalano</div>
<div style="font-family: Aptos, Aptos_EmbeddedFont, Aptos_MSFontService, Calibri, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);" class="elementToProof">
Senior Scientist,</div>
<div style="font-family: Aptos, Aptos_EmbeddedFont, Aptos_MSFontService, Calibri, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);" class="elementToProof">
NanoImaging Services & Proteos</div>
</div>
The information transmitted by this email is intended only for the person or entity to which it is addressed. This email may contain proprietary, business-confidential and/or privileged material. If you are not the intended recipient of this message, be aware
that any use, review, retransmission, distribution, reproduction or any action taken in reliance upon this message is strictly prohibited. If you received this in error, please contact the sender and delete the material from all computers.
</body>
</html>