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<p class="MsoNormal"><span style="font-size:11.0pt">Dear colleagues</span></p>
<p class="MsoNormal"><span style="font-size:11.0pt"> </span></p>
<p class="MsoNormal"><span style="font-size:11.0pt">We have an exciting opportunity for a Postdoctoral Research Associate to join the electron Bio-Imaging Centre (eBIC) at Diamond Light Source to study the structural basis of bacteriophage host-cell lysis.
The successful candidate will use high resolution Cryo-Tomography as well as single particle Cryo-EM to unravel the molecular mechanisms by which bacteriophages escape from the host cell. The position is for a fixed period of 3 years.</span></p>
<p class="MsoNormal"><span style="font-size:11.0pt"> </span></p>
<p class="MsoNormal"><span style="font-size:11.0pt">The project is a collaboration between the group of Dr. Christos Savva at eBIC and Prof. Ryland Young at Texas A&M University. eBIC is the UK National Centre for cryo-electron microscopy in the life sciences.
eBIC provides scientists with state-of-the-art equipment and expertise in the field of cryo-electron microscopy (CryoEM), for single particle analysis, cryo-electron tomography and electron crystallography. Together with eBIC for Industry, our site hosts eight
TEM microscopes for the life sciences (5 Titan Krios's, 1 Talos Arctica, 2 Glacios's), 2 Dual Beam SEM’s capable of lamella milling (Scios and Aquilos 2 with cryo lift out) and a Leica cryoCLEM.</span></p>
<p class="MsoNormal"><span style="font-size:11.0pt"> </span></p>
<p class="MsoNormal"><span style="font-size:11.0pt">For previous work please see:</span></p>
<p class="MsoNormal"><u><span style="font-size:11.0pt;color:#467886"><a href="https://urldefense.com/v3/__https://pubmed.ncbi.nlm.nih.gov/38126784/__;!!Mih3wA!F0ipUvmM_FrqtXhNmpo7hwfbPhFZ2wtKKTrgJZUKjCIVM24f-xgA4ezjRQsMe2Jetufy1AOrFDLfOvjERM-FmmoBTtDqrwPbhg$"><span style="color:#467886">Spatial and temporal control of lysis by the
</span></a><a href="https://urldefense.com/v3/__https://pubmed.ncbi.nlm.nih.gov/38126784/__;!!Mih3wA!F0ipUvmM_FrqtXhNmpo7hwfbPhFZ2wtKKTrgJZUKjCIVM24f-xgA4ezjRQsMe2Jetufy1AOrFDLfOvjERM-FmmoBTtDqrwPbhg$"><span style="color:#467886">lambda</span></a><a href="https://urldefense.com/v3/__https://pubmed.ncbi.nlm.nih.gov/38126784/__;!!Mih3wA!F0ipUvmM_FrqtXhNmpo7hwfbPhFZ2wtKKTrgJZUKjCIVM24f-xgA4ezjRQsMe2Jetufy1AOrFDLfOvjERM-FmmoBTtDqrwPbhg$"><span style="color:#467886"> holin.</span></a></span></u></p>
<p class="MsoNormal"><u><span style="font-size:11.0pt;color:#467886"><a href="https://urldefense.com/v3/__https://pubmed.ncbi.nlm.nih.gov/24164554/__;!!Mih3wA!F0ipUvmM_FrqtXhNmpo7hwfbPhFZ2wtKKTrgJZUKjCIVM24f-xgA4ezjRQsMe2Jetufy1AOrFDLfOvjERM-FmmoBTtBbLK7fRA$"><span style="color:#467886">Stable micron-scale holes are a general feature of canonical holins.</span></a></span></u></p>
<p class="MsoNormal"><u><span style="font-size:11.0pt;color:#467886"><a href="https://urldefense.com/v3/__https://pubmed.ncbi.nlm.nih.gov/20080651/__;!!Mih3wA!F0ipUvmM_FrqtXhNmpo7hwfbPhFZ2wtKKTrgJZUKjCIVM24f-xgA4ezjRQsMe2Jetufy1AOrFDLfOvjERM-FmmoBTtC5pnfWNw$"><span style="color:#467886">Micron-scale holes terminate the phage infection cycle.</span></a></span></u></p>
<p class="MsoNormal"><u><span style="font-size:11.0pt;color:#467886"><a href="https://urldefense.com/v3/__https://pubmed.ncbi.nlm.nih.gov/18788120/__;!!Mih3wA!F0ipUvmM_FrqtXhNmpo7hwfbPhFZ2wtKKTrgJZUKjCIVM24f-xgA4ezjRQsMe2Jetufy1AOrFDLfOvjERM-FmmoBTtDjIWWH1w$"><span style="color:#467886">The holin of bacteriophage
</span></a><a href="https://urldefense.com/v3/__https://pubmed.ncbi.nlm.nih.gov/18788120/__;!!Mih3wA!F0ipUvmM_FrqtXhNmpo7hwfbPhFZ2wtKKTrgJZUKjCIVM24f-xgA4ezjRQsMe2Jetufy1AOrFDLfOvjERM-FmmoBTtDjIWWH1w$"><span style="color:#467886">lambda</span></a><a href="https://urldefense.com/v3/__https://pubmed.ncbi.nlm.nih.gov/18788120/__;!!Mih3wA!F0ipUvmM_FrqtXhNmpo7hwfbPhFZ2wtKKTrgJZUKjCIVM24f-xgA4ezjRQsMe2Jetufy1AOrFDLfOvjERM-FmmoBTtDjIWWH1w$"><span style="color:#467886"> forms rings with large diameter.</span></a></span></u></p>
<p class="MsoNormal"><span style="font-size:11.0pt"> </span></p>
<p class="MsoNormal"><span style="font-size:11.0pt"> </span></p>
<p class="MsoNormal"><b><span style="font-size:11.0pt">About You</span></b></p>
<p class="MsoNormal"><span style="font-size:11.0pt">You will hold or be close to completing a PhD in life sciences, with strong experience in structural biology (Cryo-EM, SPA and/or Tomography) and expertise in bacterial expression systems and protein purification.
Experience in microbiology/phage biology will be considered an advantage but not essential.</span></p>
<p class="MsoNormal"><span style="font-size:11.0pt"> </span></p>
<p class="MsoNormal"><span style="font-size:11.0pt">For informal enquiries feel free to contact Christos Savva (<a href="mailto:christos.savva@diamond.ac.uk">christos.savva@diamond.ac.uk</a>)<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt">The Application deadline is July 13<sup>th</sup> 2025. For full details of the position and to apply please visit:<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><a href="https://urldefense.com/v3/__https://vacancies.diamond.ac.uk/vacancy/pdra-structural-basis-of-bacteriophage-host-cell-lysis-588077.html__;!!Mih3wA!F0ipUvmM_FrqtXhNmpo7hwfbPhFZ2wtKKTrgJZUKjCIVM24f-xgA4ezjRQsMe2Jetufy1AOrFDLfOvjERM-FmmoBTtCs0IF1cg$">https://vacancies.diamond.ac.uk/vacancy/pdra-structural-basis-of-bacteriophage-host-cell-lysis-588077.html</a></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt"> </span></p>
<p class="MsoNormal"><span style="font-size:11.0pt"> Best wishes<o:p></o:p></span></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><i><span style="font-size:11.0pt">Christos Savva</span></i></p>
<p class="MsoNormal"><i><span style="font-size:11.0pt">Principal EM Scientist</span></i></p>
<p class="MsoNormal"><span style="font-size:11.0pt"> </span></p>
<p class="MsoNormal"><i><span style="font-size:11.0pt">Office Tel: +44 1235 778 976</span></i></p>
<p class="MsoNormal"><i><span style="font-size:11.0pt"> </span></i></p>
<p class="MsoNormal"><span style="font-size:11.0pt"><img border="0" width="113" height="32" style="width:1.177in;height:.3333in" id="Picture_x0020_1" src="cid:image001.png@01DBDC7F.B9C3DD20" alt="signature_3278397444"></span></p>
<p class="MsoNormal"><b><span style="font-size:11.0pt">electron Bio-Imaging Centre (eBIC)</span></b><span style="font-size:11.0pt"> </span></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Diamond Light Source Ltd </span></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Diamond House </span></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Harwell Science and Innovation Campus </span></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Didcot Oxfordshire OX11 0DE </span></p>
<p class="MsoNormal"><span style="font-size:11.0pt"> </span></p>
<p class="MsoNormal"><b><u><span style="font-size:11.0pt;color:#0563C1"><a href="https://urldefense.com/v3/__https://www.diamond.ac.uk/Instruments/Biological-Cryo-Imaging/eBIC.html__;!!Mih3wA!F0ipUvmM_FrqtXhNmpo7hwfbPhFZ2wtKKTrgJZUKjCIVM24f-xgA4ezjRQsMe2Jetufy1AOrFDLfOvjERM-FmmoBTtCCAlmvIA$" target="_blank"><span style="color:#0563C1">eBIC website</span></a></span></u></b><span style="font-size:11.0pt"> </span></p>
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