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Dear all,</div>
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The American Crystallographic Association will be holding their 75h annual meeting this year in July. Come join us at ACA's diamond celebration!<br>
<br>
As always, the structural sciences are leading the way, and we have several sessions and workshops sponsored by the cryoEM SIG that may be of interest to you. </div>
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Do note, the deadline for oral <a href="https://urldefense.com/v3/__https://www.acameeting2025.com/call-for-abstracts__;!!Mih3wA!AqWH3go4r_BBgjUm9jrZfM7z2eQyxphniRNPKi5zGYBbxAn6E7RMAkgAmCAv1CXCeLyw2eyq4Zw5QKc$" id="OWA258a8936-1671-6b98-1e2f-7ed5c7bc2c1d" class="OWAAutoLink elementToProof" data-auth="NotApplicable" style="margin: 0px; text-align: left;">
abstracts</a> is March 31st:<br>
<br>
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<b>Innovations in sample preparation and other hardware in cryoEM</b></div>
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(Chairs: Ed Eng and David Taylor)<br>
<br>
<b>Innovations in algorithms and computational methods in cryoEM<br>
</b>(Chairs: Alexis Rohou and Joey Davis)<br>
<br>
<b>From cells to atoms – using cryoEM approaches to address biological questions<br>
</b>(Chairs: Juan Du and Ben Barad)<br>
<br>
<b>Structure of Nucleic Acids – cryoEM<br>
</b>(Chairs: Melanie Ohi and Peter Hsu)</div>
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<b>Workshop: Applications of Visualization Technology in the Structural Sciences<br>
</b>(Organizers: Ed Eng and Nichole Valdez)</div>
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Find out more here: <a href="https://urldefense.com/v3/__https://www.acameeting2025.com/__;!!Mih3wA!AqWH3go4r_BBgjUm9jrZfM7z2eQyxphniRNPKi5zGYBbxAn6E7RMAkgAmCAv1CXCeLyw2eyqx5DjRh0$" id="LPlnk">https://www.acameeting2025.com/</a></div>
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Best,</div>
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Ed</div>
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<div id="Signature" class="elementToProof"><span style="font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 8pt; color: rgb(0, 0, 0); background-color: rgb(255, 255, 255);">---</span><span style="font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);"><br>
</span></div>
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<span style="background-color: rgb(255, 255, 255);">Edward T. Eng, Ph.D.</span></div>
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<span style="background-color: rgb(255, 255, 255);">Senior Scientist, Manager</span></div>
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<span style="background-color: rgb(255, 255, 255);">New York Structural Biology Center</span></div>
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<span style="background-color: rgb(255, 255, 255);">nysbc.org | (212)939-0660 x344</span></div>
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<div dir="ltr" id="divRplyFwdMsg"><span style="font-family: Calibri, sans-serif; font-size: 11pt; color: rgb(0, 0, 0);"><b>From:</b> Alexis Rohou <rohou.alexis@gene.com><br>
<b>Sent:</b> Monday, March 17, 2025 11:44 AM<br>
<b>To:</b> 3dem@ncmir.ucsd.edu <3dem@ncmir.ucsd.edu>; CCPEM@jiscmail.ac.uk <CCPEM@jiscmail.ac.uk><br>
<b>Cc:</b> Ed Eng <eeng@nysbc.org>; David Taylor <dtaylor@utexas.edu>; Joey Davis <jhdavis@mit.edu>; Juan Du <juan.du@northwestern.edu>; Benjamin Barad <barad@ohsu.edu>; Melanie Ohi <mohi@umich.edu>; Peter Hsu <hsup2@gene.com><br>
<b>Subject:</b> Re: ACA 2025 - invitation to attend & submit abstracts!</span>
<div> </div>
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<div style="direction: ltr;">Dear colleagues,<br>
<br>
A reminder to submit your abstracts and join us at the <a href="https://urldefense.com/v3/__https://www.acameeting2025.com/__;!!Mih3wA!AqWH3go4r_BBgjUm9jrZfM7z2eQyxphniRNPKi5zGYBbxAn6E7RMAkgAmCAv1CXCeLyw2eyqx5DjRh0$" id="OWA0fbe70fd-53dd-0889-5b78-09a250eb5a87" class="OWAAutoLink" data-auth="NotApplicable">
ACA's 75th annual meeting</a> in Chicago/Lombard, Illinois, July 18-23, 2025.</div>
<div style="direction: ltr;"><br>
</div>
<div style="direction: ltr;">The CryoEM Special Interest Group is organizing several
<a href="https://urldefense.com/v3/__https://www.acameeting2025.com/sessions__;!!Mih3wA!AqWH3go4r_BBgjUm9jrZfM7z2eQyxphniRNPKi5zGYBbxAn6E7RMAkgAmCAv1CXCeLyw2eyqj05FUQE$" id="OWA7419d830-6d8b-befc-a5bd-94941192234d" class="OWAAutoLink" data-auth="NotApplicable">
sessions</a> (see below) which could be a great home for your science. We encourage you to submit your abstracts!</div>
<div style="direction: ltr;"><br>
</div>
<div class="elementToProof" style="direction: ltr;">The deadline for <a href="https://urldefense.com/v3/__https://www.acameeting2025.com/call-for-abstracts__;!!Mih3wA!AqWH3go4r_BBgjUm9jrZfM7z2eQyxphniRNPKi5zGYBbxAn6E7RMAkgAmCAv1CXCeLyw2eyq4Zw5QKc$" id="OWA44478a00-7c9c-bd7e-44fe-3a94d85d9290" class="OWAAutoLink" data-auth="NotApplicable">
abstract submission</a> is March 31st. </div>
<div style="direction: ltr;"><br>
</div>
<div style="direction: ltr;">There are also several <a href="https://urldefense.com/v3/__https://www.acameeting2025.com/workshops__;!!Mih3wA!AqWH3go4r_BBgjUm9jrZfM7z2eQyxphniRNPKi5zGYBbxAn6E7RMAkgAmCAv1CXCeLyw2eyqGFAHS28$" id="OWA8f2389d9-6054-5436-952a-0289f7a8c78a" class="OWAAutoLink" data-auth="NotApplicable">
workshops</a> available, which may be of interest to newcomers to the field, or those looking to brush up their skills!</div>
<div style="direction: ltr;"><br>
</div>
<div style="direction: ltr;">If you have any questions, don't hesitate to ask any of the cryoEM session co-chairs listed below. </div>
<div style="direction: ltr;"><br>
</div>
<div style="direction: ltr;">Cheers,</div>
<div style="direction: ltr;">Alexis</div>
<div style="direction: ltr;"><br>
</div>
<div style="direction: ltr;">(on behalf of the cryoEM SIG and of all the session co-chairs: Ed Eng, David Taylor, Joey Davis, Juan Du, Ben Barad, Melanie Ohi and Peter Hsu)</div>
<div style="direction: ltr;"><br>
</div>
<div style="direction: ltr;">On Mon, Feb 10, 2025 at 5:00 AM Alexis Rohou <<a href="mailto:rohoua@gene.com" id="OWA229d3773-d5d1-49ca-d191-54f2b0cae4cc" class="OWAAutoLink">rohoua@gene.com</a>> wrote:</div>
<blockquote style="margin: 0px 0px 0px 0.8ex; padding-left: 1ex; border-left: 1px solid rgb(204, 204, 204);">
<div style="direction: ltr;">Dear colleagues,</div>
<div style="direction: ltr;"><br>
</div>
<div style="direction: ltr;">We are now accepting abstract submissions for the <a href="https://urldefense.com/v3/__https://www.acameeting2025.com/__;!!Mih3wA!AqWH3go4r_BBgjUm9jrZfM7z2eQyxphniRNPKi5zGYBbxAn6E7RMAkgAmCAv1CXCeLyw2eyqx5DjRh0$" id="OWA886fbf75-012f-6bdc-4b0e-b1aec9809aaf" class="OWAAutoLink" data-auth="NotApplicable">
2025 annual meeting of the ACA</a>, to be held July 18-23 in Lombard, Illinois. </div>
<div style="direction: ltr;"><br>
</div>
<div style="direction: ltr;">Please submit your abstracts by March 31 to:</div>
<div style="direction: ltr;"><a href="https://urldefense.com/v3/__https://auth.oxfordabstracts.com/?redirect=*stages*77680*submitter__;Ly8v!!Mih3wA!AqWH3go4r_BBgjUm9jrZfM7z2eQyxphniRNPKi5zGYBbxAn6E7RMAkgAmCAv1CXCeLyw2eyq6S4zViA$" id="OWA6a055edf-ad78-fbed-5d5c-6b2ed663e91f" class="OWAAutoLink" data-auth="NotApplicable">https://auth.oxfordabstracts.com/?redirect=/stages/77680/submitter</a></div>
<div style="direction: ltr;"><br>
</div>
<div style="direction: ltr;">The ACA is the Structural Science Society. In recent years, the ACA's annual meeting has become a wonderful home to the cryoEM community, with excellent oral and poster presentations, discussions and networking opportunities. Memorably,
this led Sriram Subramaniam, one of our invited speakers in 2022, to open his remarks with "Thank you for inviting me to the annual meeting of the American CryoEM Association".</div>
<div style="direction: ltr;"><br>
</div>
<div style="direction: ltr;">This year's meeting features numerous sessions and workshops that will be of interest to the cryoEM/cryoET community. I encourage you to take a look at
<a href="https://urldefense.com/v3/__https://www.acameeting2025.com/sessions__;!!Mih3wA!AqWH3go4r_BBgjUm9jrZfM7z2eQyxphniRNPKi5zGYBbxAn6E7RMAkgAmCAv1CXCeLyw2eyqj05FUQE$" id="OWA7b9115cc-7c41-0085-e1ff-85674f911aed" class="OWAAutoLink" data-auth="NotApplicable">
the meeting's program</a>. </div>
<div style="direction: ltr;"><br>
</div>
<div style="direction: ltr;">The cryoEM Special Interest Group (SIG) is organizing four oral sessions and one workshop, listed below. I highly encourage you, on behalf of the SIG and the co-chairs, to submit abstracts to the sessions, register for the workshop,
and/or to reach out to any of us with any question you may have.</div>
<div style="direction: ltr;"><br>
</div>
<div style="direction: ltr;">Cheers,</div>
<div style="direction: ltr;">Alexis</div>
<div style="direction: ltr;">(on behalf of the cryoEM SIG and of all the session co-chairs: Ed Eng, David Taylor, Joey Davis, Juan Du, Ben Barad, Melanie Ohi and Peter Hsu)</div>
<div style="direction: ltr;"><br>
</div>
<div style="direction: ltr;"><b>Innovations in sample preparation and other hardware in cryoEM</b></div>
<div style="direction: ltr;">(Chairs: Ed Eng and David Taylor)<br>
<br>
Advances in cryoEM and cryoET methods and technology have revolutionized our ability to see the atomic structure of proteins, and macromolecular machines in the cellular environment, respectively. Despite these breakthroughs, challenges in sample preparation
and instrumentation continue to be critical areas for innovation. Join us to learn about new developments in sample preparation and other technologies that address current challenges and open doors to exciting areas of biology.<br>
<br>
<br>
<b>Innovations in algorithms and computational methods in cryoEM<br>
</b>(Chairs: Alexis Rohou and Joey Davis)<br>
<br>
Many challenges remain in the quest to fully unlock the potential of cryoEM for structural studies of biology. How can we resolve fine details of dynamic, flexible assemblies? What is the best way to study the structures of macromolecules in their native, cellular
context? How can we control our instruments more efficiently for high-throughput, automated high-resolution imaging? What are the optimal methods for obtaining and validating accurate and reliable atomic models for molecules of interest? For these and many
other challenges, the development of improved computational methods and algorithms remains a key stone of the field. This session will cover some of the latest computational work in cryoEM and cryoET.<br>
<br>
<b>From cells to atoms – using cryoEM approaches to address biological questions<br>
</b>(Chairs: Juan Du and Ben Barad)<br>
<br>
The ability to determine 3D structures of biological systems has skyrocketed due to recent advances in cryoEM. This section will focus on the use of single particle cryo-EM and cryo-electron tomography to understand the molecular basis of biological processes.<br>
<br>
<b>Structure of Nucleic Acids – cryoEM<br>
</b>(Chairs: Melanie Ohi and Peter Hsu)<br>
<br>
RNA, DNA, and nucleic acid-protein complexes remain challenging targets for structural biology. Nucleic acids are often structurally flexible even when complexed to their protein partners and it can be difficult to purify large enough quantities of stable nucleic
acids or nucleic-protein complexes for conventional structural approaches such as NMR or X-ray crystallography. This session focuses on presenting successful examples of adopting approaches and techniques for using single particle cryo-EM to determine structures
of dynamic nucleic acids and nucleic-protein complexes.</div>
<div style="direction: ltr;"><br>
</div>
<div style="direction: ltr;"><b>Workshop: Applications of Visualization Technology in the Structural Sciences<br>
</b>(Organizers: Ed Eng and Nichole Valdez)</div>
<div style="direction: ltr;"><br>
The Structural Science Visualization Technology Workshop at the Chicago ACA Meeting will focus on the latest advancements in visualization techniques for structural sciences, particularly in cryo-electron microscopy and X-ray crystallography. The workshop will
cover cutting-edge visualization tools such as 2D and 3D molecular animations, virtual reality (VR), augmented reality (AR), and 3D printing to enhance the presentation and understanding of molecular structures. Attendees will engage in expert-led lectures,
hands-on demonstrations, and discussions to explore how these technologies can be applied in scientific communication, education, and drug design.<br>
<br>
Participants can look forward to an immersive learning experience where they will gain practical skills in using animation, VR, AR, and 3D printing to visualize complex structural data. The workshop will feature renowned experts from institutions such as the
University of Utah, UC San Diego, and Schrödinger, offering insights into the latest tools like PyMOL3, syGlassVR, and Nanome.ai. Attendees will engage in interactive sessions, including hands-on demonstrations of 3D/4D visualization, molecular animations,
and real-time virtual collaboration for chemical and pharmaceutical research. The event is ideal for scientists, educators, and students looking to enhance their ability to present structural data in innovative and compelling ways, making their research more
accessible and impactful.<br>
<br>
</div>
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<div style="direction: ltr;">--</div>
<div style="direction: ltr; font-size: 12.8px; color: rgb(136, 136, 136);"><b>Alexis Rohou</b><br>
Senior Principal Scientist</div>
<div style="direction: ltr; font-size: 12.8px; color: rgb(136, 136, 136);">Director of CryoEM</div>
<div style="direction: ltr; font-size: 12.8px; color: rgb(136, 136, 136);">Genentech, Department of Structural Biology</div>
<div style="direction: ltr; font-size: 12.8px; color: rgb(136, 136, 136);">1 DNA Way</div>
<div style="direction: ltr; font-size: 12.8px; color: rgb(136, 136, 136);">South San Francisco, CA 94080</div>
<div style="direction: ltr; font-size: 12.8px; color: rgb(136, 136, 136);">Cell: 781 249 9629</div>
<div style="direction: ltr; font-size: 12.8px; color: rgb(136, 136, 136);">Pronouns: he/him/his</div>
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