<html><head><meta http-equiv="Content-Type" content="text/html; charset=utf-8"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class="">Daer all,<div class=""><br class=""></div><div class="">just a reminder about the position below. We will still be collecting CVs for another 2 weeks.</div><div class=""><br class=""></div><div class="">Best regards,</div><div class="">Daniel</div><div><br class=""><blockquote type="cite" class=""><div class="">Begin forwarded message:</div><br class="Apple-interchange-newline"><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px;" class=""><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif; color:rgba(0, 0, 0, 1.0);" class=""><b class="">From: </b></span><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif;" class="">Daniel Lietha <<a href="mailto:daniel.lietha@cib.csic.es" class="">daniel.lietha@cib.csic.es</a>><br class=""></span></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px;" class=""><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif; color:rgba(0, 0, 0, 1.0);" class=""><b class="">Subject: </b></span><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif;" class=""><b class="">2-year postdoc position in AI based Protein design and Structural biology at CSIC, Madrid, Spain</b><br class=""></span></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px;" class=""><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif; color:rgba(0, 0, 0, 1.0);" class=""><b class="">Date: </b></span><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif;" class="">20 December 2024 at 15:24:48 CET<br class=""></span></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px;" class=""><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif; color:rgba(0, 0, 0, 1.0);" class=""><b class="">To: </b></span><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif;" class=""><a href="mailto:3dem@ncmir.ucsd.edu" class="">3dem@ncmir.ucsd.edu</a><br class=""></span></div><br class=""><div class=""><meta http-equiv="Content-Type" content="text/html; charset=utf-8" class=""><div style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><span class="" style="font-size: 14px;">Dear all,</span><div class=""><span class="" style="font-size: 14px;"><br class=""></span></div><div class=""><span class="" style="font-size: 14px;">We are seeking a motivated scientist to join our team to use <b class="">artificial </b>i<b class="">ntelligence (AI) based methods to design novel proteins with therapeutic potential</b> as well as to <b class="">experimentally validate and characterize the designed proteins</b>. The project is funded by Worldwide Cancer Research and aims to target regulatory sites in a well-known cancer target, known to efficiently and selectively inhibit cancer cell invasion.<br class=""><br class="">The candidate will be based at the Margarita Salas Center for Biological Research (CIB-CSIC) in Madrid. She/He will work in a multidisciplinary and international team with experience in structural biology of the target (Lietha Lab, CIB-CSIC, Spain) [1], AI based protein design (Baker Lab, University of Washington, USA) [2] and relevant cancer models (Frame Lab, Cancer Research UK Edinburgh Centre) [3]. The candidate should have experience in computational structural biology, while experience with experimental biochemistry and/or structural biology techniques will be a plus.<br class=""><br class=""></span><div class=""><span class="" style="font-size: 14px;">To express your interest and send your CV or to find out more, please contact Daniel Lietha (<a href="mailto:daniel.lietha@cib.csic.es" class="">daniel.lietha@cib.csic.es</a>). All enquiries and applications will be treated confidentially.<br class=""><br class="">I would be very grateful if you could distribute the advertisement at your institute and among potential candidates (see also attached pdf).</span></div><div class=""><span class="" style="font-size: 14px;"><br class=""></span></div><div class=""><span class="" style="font-size: 14px;">Kind regards,</span></div><div class=""><span class="" style="font-size: 14px;">Daniel</span><br class=""><br class=""><br class=""><span class="" style="font-size: 12px;">References:<br class=""></span></div><span class="" style="font-size: 12px;">1. Acebrón I, Righetto RD, Schoenherr C, de Buhr S, Redondo P, Culley J, Rodríguez CF, Daday C, Biyani N, Llorca O, Byron A, Chami M, Gräter F, Boskovic J, Frame MC, Stahlberg H, Lietha D. Structural basis of Focal Adhesion Kinase activation on lipid membranes. EMBO J 39, e104743 (2020).<br class=""><br class="">2. Watson JL, Juergens D, Bennett NR, Trippe BL, Yim J, Eisenach HE, Ahern W, Borst AJ, Ragotte RJ, Milles LF, Wicky BIM, Hanikel N, Pellock SJ, Courbet A, Sheffler W, Wang J, Venkatesh P, Sappington I, Torres SV, Lauko A, De Bortoli V, Mathieu E, Ovchinnikov S, Barzilay R, Jaakkola TS, DiMaio F, Baek M, Baker D. De novo design of protein structure and function with RFdiffusion. Nature 620, 1089-1100 (2023).<br class=""><br class="">3. M, Dawson JC, Avalle L, Douglas AT, Mort RL, Byron A, Carragher NO, Pollard SM, Brunton VG, Frame MC. An ILK/STAT3 pathway controls glioblastoma stem cell plasticity. Dev Cell. 2024 Dec 16;59(24):3197-3212</span></div><div class=""><br class=""></div><div class="">
<div dir="auto" style="caret-color: rgb(0, 0, 0); letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none; word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><div dir="auto" style="caret-color: rgb(0, 0, 0); letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none; word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><div dir="auto" style="text-align: start; text-indent: 0px; word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><div dir="auto" style="text-align: start; text-indent: 0px; word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><div dir="auto" style="text-align: start; text-indent: 0px; word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><div dir="auto" style="text-align: start; text-indent: 0px; word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><div dir="auto" style="text-align: start; text-indent: 0px; word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><div dir="auto" style="text-align: start; text-indent: 0px; word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><p class="MsoNormal"><span style="caret-color: rgb(0, 0, 0); color: rgb(59, 56, 56); letter-spacing: normal; text-transform: none; white-space: normal; word-spacing: 0px; text-decoration: none; -webkit-text-stroke-width: 0px; font-size: 7.5pt; font-family: Arial, sans-serif;" class="">______________________________________________________<br class=""></span><b style="caret-color: rgb(0, 0, 0); letter-spacing: normal; text-transform: none; white-space: normal; word-spacing: 0px; text-decoration: none; -webkit-text-stroke-width: 0px;" class=""><span style="font-size: 9pt; font-family: Arial, sans-serif; color: rgb(47, 85, 151);" class="">Daniel Lietha, PhD<br class=""></span></b><span style="caret-color: rgb(0, 0, 0); color: rgb(59, 56, 56); letter-spacing: normal; text-transform: none; white-space: normal; word-spacing: 0px; text-decoration: none; -webkit-text-stroke-width: 0px; font-size: 8pt; font-family: Arial, sans-serif;" class="">Group Leader<br class="">Cell Signalling and Adhesion Group<br class="">Cellular and Molecular Biosciences<br class="">Margarita Salas Center for Biological Research<br class="">Spanish National Research Council (CSIC)<br class="">Calle Ramiro de Maeztu 9, E-28040 Madrid, Spain<br class="">Tel: + (34) 911 098 016</span><span style="caret-color: rgb(0, 0, 0); color: rgb(59, 56, 56); letter-spacing: normal; text-transform: none; white-space: normal; word-spacing: 0px; text-decoration: none; -webkit-text-stroke-width: 0px; font-size: 8pt; font-family: Arial, sans-serif;" class=""><br class=""><a href="mailto:daniel.lietha@cib.csic.es" class="">Email: daniel.lietha@cib.csic.es</a><br class=""></span><font color="#0069d9" face="Arial, sans-serif" size="1" class=""><u class=""><a href="https://urldefense.com/v3/__https://cib.csic.es/research/cellular-and-molecular-biology/cell-signalling-and-adhesion__;!!Mih3wA!E0N_nXXrKGV9OF3JbyYMqIPK2Gi-wBC1xB4oIW1yq86dvL1orZzPWpUddgrFfsyVUeWzHm_An2EcUzIDUnY7ADdEsWiZsg$" class="">https://cib.csic.es/research/cellular-and-molecular-biology/cell-signalling-and-adhesion</a></u></font></p><p class="MsoNormal"><br class=""></p></div></div></div></div></div></div></div></div>
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