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<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif">Dear all,<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif">A PhD studentship is available in Prof Peijun Zhang’s group at Oxford University, in collaboration with Joana Sousa at UCB Pharma, for the structural investigation of AAV (adeno-associated
virus) by cryoEM and its intracellular trafficking using in situ cryo-electron tomography (cryo-ET).
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif">Recombinant AAV has emerged as a leading delivery vector for gene therapy. However, to achieve greater therapeutic efficacy, high doses are often required, which increase
the risk of serious adverse events. To develop better AAV vectors that are more efficient at delivering their therapeutic payload, a deeper understanding of the cellular barriers that impede successful cell transduction is needed.
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif">We are seeking a highly motivated student to carry on this study. The successful candidate will use cryo-FIB, cryo-ET and CLEM techniques to characterise AAVs and their cellular
infection processes. The student will be primarily based at Oxford University but will also spend time at UCB Pharma in the UK. The project covers techniques in molecular, cellular and structural biology, including AAV production and infection, biochemical/biophysical
characterization, cryo-electron tomography and subtomogram averaging, cryo-FIB/SEM and in situ structural biology.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif">We are located in the Division of Structural Biology within the Nuffield Department of Medicine (<a href="https://urldefense.com/v3/__https://www.strubi.ox.ac.uk/research/professor-peijun-zhang__;!!Mih3wA!H5Fwa1nNxNRTe5bVVdTkTWS4UmnJxoxIoAF8YySg0J-sm-g3_62IsDL6cu2jruqNKaP-79V-dH0-YZ722Oyb044v7U05lwDG$">https://www.strubi.ox.ac.uk/research/professor-peijun-zhang</a>),
which provides an ideal environment for multidisciplinary and integrative studies. We also have access to eBIC and Diamond Light Source for data collection (<a href="https://urldefense.com/v3/__https://www.diamond.ac.uk/Instruments/Biological-Cryo-Imaging/eBIC.html__;!!Mih3wA!H5Fwa1nNxNRTe5bVVdTkTWS4UmnJxoxIoAF8YySg0J-sm-g3_62IsDL6cu2jruqNKaP-79V-dH0-YZ722Oyb044v7Sm7AI1g$">https://www.diamond.ac.uk/Instruments/Biological-Cryo-Imaging/eBIC.html</a>).
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif">UCB is a global biopharma company focused on creating valuable solutions that make improvements to the lives of people living with neurological and autoimmune conditions. For
further information please visit <a href="https://urldefense.com/v3/__https://www.ucb.com/__;!!Mih3wA!H5Fwa1nNxNRTe5bVVdTkTWS4UmnJxoxIoAF8YySg0J-sm-g3_62IsDL6cu2jruqNKaP-79V-dH0-YZ722Oyb044v7fcxsYWj$">https://www.ucb.com/</a>.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif">For further inquiries, please contact Peijun Zhang (<a href="mailto:peijun.zhang@strubi.ox.ac.uk">peijun.zhang@strubi.ox.ac.uk</a>).<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif">Best,<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif">Peijun<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif"><o:p> </o:p></span></p>
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