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<p>Dear EM enthusiasts,<br>
<br>
Please find below details about a new open position for a Research
Scientist to join the cryo-EM team in ALPX.<br>
<br>
Thank you and kind regards, <br>
Erika<br>
<br>
</p>
<p><b>Research Scientist in Cryo-Electron Microscopy at ALPX</b><br>
<br>
<u>Position description:</u><br>
<br>
ALPX is an EMBL Spin-off Company located in Grenoble, France (<a class="moz-txt-link-freetext" href="https://urldefense.com/v3/__http://alpx-services.com__;!!Mih3wA!FzbCyxktOWsrcEGGj8lRvJeFvqe6eGR9eRnNfq_OCAxDwIGPDLOd1jHlc6-_pvIOAorA46BZk0vYMHRa83yUNohoAhM6$">http://alpx-services.com</a>).
We offer innovative research services based on the CrystalDirect
technology for structural biology and small-molecule drug
discovery to the pharmaceutical and biotech industries. Starting
in 2025, we will also offer a rapid and agile Single Particle
Analysis cryo-Electron Microscopy (SPA cryo-EM) full service,
encompassing everything from cryo-EM sample preparation to
structure determination.<br>
<br>
We seek a highly motivated single-particle cryo-EM specialist to
join the ALPX team.<br>
<br>
The successful candidate will contribute to a range of exciting
structural biology and drug discovery projects and participate in
the development of our sample-to-solution cryo-EM service, with a
particular focus on automating on-the-fly and offline data
processing. Responsibilities include single-particle data
acquisition and analysis, implementation and optimization of
cryo-EM data storage, on-the-fly data processing, and high-quality
structure elucidation and interpretation. The candidate will also
assist in writing project proposals, working with various cryo-EM
platforms, traveling for data collection, and preparing
presentations on structural data for the project team and clients.<br>
<br>
<u>Required knowledge, skills, and abilities:</u><br>
<br>
· Ph.D. in chemistry, biology, physics, or a related field,
with an excellent track record<br>
<br>
· Multiple cryo-EM map/structure depositions and
peer-reviewed publications<br>
<br>
· Demonstrated extensive experience in hands-on TEM
operation (Tecnai T12, Glacios, Titan Krios), data acquisition,
image processing, model building<br>
<br>
· Strong expertise in a variety of cryo-EM and structural
analysis software (i.e., Relion, CryoSPARC, EMAN, CCPEM, Chimera
and COOT)<br>
<br>
· Experience in high-resolution structure determination by
cryo-EM, including model building from scratch and structure
refinement (Cccp4 and Phenix)<br>
<br>
· Scripting experience (Shell, Python)<br>
<br>
· Team player with the ability to work on several projects
in parallel<br>
<br>
· Strong oral and written English communication and
organisation skills<br>
<br>
<u>Preferred knowledge, skills, and abilities:</u><br>
<br>
· Experience in SPA cryo-EM on membrane proteins and
epitopes mapping<br>
<br>
· Experience in Industry/CRO/CMO<br>
<br>
· Familiarity with HPC and Cloud Platforms<br>
<br>
· Experience in cryo-electron tomography (Cryo-ET) and
sub-tomogram averaging<br>
<br>
The position is permanent and immediately available. <b>Deadline
for application: 17.11.2024.</b><br>
<br>
If you are enthusiastic about this position but find that your
previous experience does not precisely match every requirement
outlined in the job description, we still encourage you to apply.
We are looking forward to hearing from you.<br>
<br>
Please send your motivation letter, CV, and names of two referees
to <a class="moz-txt-link-abbreviated moz-txt-link-freetext"
href="mailto:recruitment@alpx-services.com">recruitment@alpx-services.com</a><br>
<br>
<br>
linkedin.com/company/alpx-sas <br>
</p>
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<div><strong>Erika Pellegrini</strong></div>
<div class="alpx">Research scientist</div>
<div><a href="mailto:pellegrini@alpx-services.com"
class="moz-txt-link-freetext">pellegrini@alpx-services.com</a></div>
<a href="https://urldefense.com/v3/__https://alpx-services.com__;!!Mih3wA!FzbCyxktOWsrcEGGj8lRvJeFvqe6eGR9eRnNfq_OCAxDwIGPDLOd1jHlc6-_pvIOAorA46BZk0vYMHRa83yUNoxK_iQw$" class="moz-txt-link-freetext">https://alpx-services.com</a>
<p> <a href="https://urldefense.com/v3/__https://alpx-services.com__;!!Mih3wA!FzbCyxktOWsrcEGGj8lRvJeFvqe6eGR9eRnNfq_OCAxDwIGPDLOd1jHlc6-_pvIOAorA46BZk0vYMHRa83yUNoxK_iQw$"><img
src="cid:part1.la6xFVpK.7hqn3ywF@alpx-services.com" alt=""
height="40px" border="0"></a> <a href="https://urldefense.com/v3/__https://www.linkedin.com/company/alpx-sas/posts/?feedView=all__;!!Mih3wA!FzbCyxktOWsrcEGGj8lRvJeFvqe6eGR9eRnNfq_OCAxDwIGPDLOd1jHlc6-_pvIOAorA46BZk0vYMHRa83yUNlMLg-cE$"><img
src="cid:part2.Uh89F4tT.8Ta0Qvwj@alpx-services.com" alt=""
height="20px" border="0"> </a> </p>
<div> 71 avenue des Martyrs <br>
38000 Grenoble, France <br>
Phone: +33476207967 </div>
<br>
<div class="small">
<p> CONFIDENTIALITY NOTICE </p>
<p> The information contained in this e-mail message is
intended only for the exclusive use of the individual or
entity named above and may contain information that is
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<p></p>
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<div>
<div><strong>Erika Pellegrini</strong></div>
<div class="alpx">Research scientist</div>
<div><a href="mailto:pellegrini@alpx-services.com"
class="moz-txt-link-freetext">pellegrini@alpx-services.com</a></div>
<a href="https://urldefense.com/v3/__https://alpx-services.com__;!!Mih3wA!FzbCyxktOWsrcEGGj8lRvJeFvqe6eGR9eRnNfq_OCAxDwIGPDLOd1jHlc6-_pvIOAorA46BZk0vYMHRa83yUNoxK_iQw$" class="moz-txt-link-freetext">https://alpx-services.com</a>
<p> <a href="https://urldefense.com/v3/__https://alpx-services.com__;!!Mih3wA!FzbCyxktOWsrcEGGj8lRvJeFvqe6eGR9eRnNfq_OCAxDwIGPDLOd1jHlc6-_pvIOAorA46BZk0vYMHRa83yUNoxK_iQw$"><img
src="cid:part3.bs0QzdG6.YtEn8YWV@alpx-services.com" alt=""
height="40px" border="0"></a> <a href="https://urldefense.com/v3/__https://www.linkedin.com/company/alpx-sas/posts/?feedView=all__;!!Mih3wA!FzbCyxktOWsrcEGGj8lRvJeFvqe6eGR9eRnNfq_OCAxDwIGPDLOd1jHlc6-_pvIOAorA46BZk0vYMHRa83yUNlMLg-cE$"><img
src="cid:part4.fQVme2Ag.Yc10SM8j@alpx-services.com" alt=""
height="20px" border="0"> </a> </p>
<div> 71 avenue des Martyrs <br>
38000 Grenoble, France <br>
Phone: +33476207967 </div>
<br>
<div class="small">
<p> CONFIDENTIALITY NOTICE </p>
<p> The information contained in this e-mail message is
intended only for the exclusive use of the individual or
entity named above and may contain information that is
privileged, confidential or exempt from disclosure under
applicable law. If the reader of this message is not the
intended recipient, or the employee or agent responsible for
delivery of the message to the intended recipient, you are
hereby notified that any dissemination, distribution or
copying of this communication is strictly prohibited. If you
have received this communication in error, please notify the
sender immediately by e-mail and delete the material from
any computer. Thank you. </p>
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