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    <p>Dear EM enthusiasts,<br>
      <br>
      Please find below details about a new open position for a Research
      Scientist to join the cryo-EM team in ALPX.<br>
      <br>
      Thank you and kind regards, <br>
      Erika<br>
      <br>
    </p>
    <p><b>Research Scientist in Cryo-Electron Microscopy at ALPX</b><br>
      <br>
      <u>Position description:</u><br>
      <br>
      ALPX is an EMBL Spin-off Company located in Grenoble, France (<a class="moz-txt-link-freetext" href="https://urldefense.com/v3/__http://alpx-services.com__;!!Mih3wA!FzbCyxktOWsrcEGGj8lRvJeFvqe6eGR9eRnNfq_OCAxDwIGPDLOd1jHlc6-_pvIOAorA46BZk0vYMHRa83yUNohoAhM6$">http://alpx-services.com</a>).
      We offer innovative research services based on the CrystalDirect
      technology for structural biology and small-molecule drug
      discovery to the pharmaceutical and biotech industries. Starting
      in 2025, we will also offer a rapid and agile Single Particle
      Analysis cryo-Electron Microscopy (SPA cryo-EM) full service,
      encompassing everything from cryo-EM sample preparation to
      structure determination.<br>
      <br>
      We seek a highly motivated single-particle cryo-EM specialist to
      join the ALPX team.<br>
      <br>
      The successful candidate will contribute to a range of exciting
      structural biology and drug discovery projects and participate in
      the development of our sample-to-solution cryo-EM service, with a
      particular focus on automating on-the-fly and offline data
      processing. Responsibilities include single-particle data
      acquisition and analysis, implementation and optimization of
      cryo-EM data storage, on-the-fly data processing, and high-quality
      structure elucidation and interpretation. The candidate will also
      assist in writing project proposals, working with various cryo-EM
      platforms, traveling for data collection, and preparing
      presentations on structural data for the project team and clients.<br>
      <br>
      <u>Required knowledge, skills, and abilities:</u><br>
      <br>
      ·        Ph.D. in chemistry, biology, physics, or a related field,
      with an excellent track record<br>
      <br>
      ·        Multiple cryo-EM map/structure depositions and
      peer-reviewed publications<br>
      <br>
      ·        Demonstrated extensive experience in hands-on TEM
      operation (Tecnai T12, Glacios, Titan Krios), data acquisition,
      image processing, model building<br>
      <br>
      ·        Strong expertise in a variety of cryo-EM and structural
      analysis software (i.e., Relion, CryoSPARC, EMAN, CCPEM, Chimera
      and COOT)<br>
      <br>
      ·        Experience in high-resolution structure determination by
      cryo-EM, including model building from scratch and structure
      refinement (Cccp4 and Phenix)<br>
      <br>
      ·        Scripting experience (Shell, Python)<br>
      <br>
      ·        Team player with the ability to work on several projects
      in parallel<br>
      <br>
      ·        Strong oral and written English communication and
      organisation skills<br>
      <br>
      <u>Preferred knowledge, skills, and abilities:</u><br>
      <br>
      ·        Experience in SPA cryo-EM on membrane proteins and
      epitopes mapping<br>
      <br>
      ·        Experience in Industry/CRO/CMO<br>
      <br>
      ·        Familiarity with HPC and Cloud Platforms<br>
      <br>
      ·        Experience in cryo-electron tomography (Cryo-ET) and
      sub-tomogram averaging<br>
      <br>
      The position is permanent and immediately available.  <b>Deadline
        for application: 17.11.2024.</b><br>
      <br>
      If you are enthusiastic about this position but find that your
      previous experience does not precisely match every requirement
      outlined in the job description, we still encourage you to apply.
      We are looking forward to hearing from you.<br>
      <br>
      Please send your motivation letter, CV, and names of two referees
      to <a class="moz-txt-link-abbreviated moz-txt-link-freetext"
        href="mailto:recruitment@alpx-services.com">recruitment@alpx-services.com</a><br>
      <br>
      <br>
      linkedin.com/company/alpx-sas <br>
    </p>
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        <div><strong>Erika Pellegrini</strong></div>
        <div class="alpx">Research scientist</div>
        <div><a href="mailto:pellegrini@alpx-services.com"
            class="moz-txt-link-freetext">pellegrini@alpx-services.com</a></div>
        <a href="https://urldefense.com/v3/__https://alpx-services.com__;!!Mih3wA!FzbCyxktOWsrcEGGj8lRvJeFvqe6eGR9eRnNfq_OCAxDwIGPDLOd1jHlc6-_pvIOAorA46BZk0vYMHRa83yUNoxK_iQw$" class="moz-txt-link-freetext">https://alpx-services.com</a>
        <p> <a href="https://urldefense.com/v3/__https://alpx-services.com__;!!Mih3wA!FzbCyxktOWsrcEGGj8lRvJeFvqe6eGR9eRnNfq_OCAxDwIGPDLOd1jHlc6-_pvIOAorA46BZk0vYMHRa83yUNoxK_iQw$"><img
              src="cid:part1.la6xFVpK.7hqn3ywF@alpx-services.com" alt=""
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        <div> 71 avenue des Martyrs <br>
          38000 Grenoble, France <br>
          Phone: +33476207967 </div>
        <br>
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          <p> CONFIDENTIALITY NOTICE </p>
          <p> The information contained in this e-mail message is
            intended only for the exclusive use of the individual or
            entity named above and may contain information that is
            privileged, confidential or exempt from disclosure under
            applicable law. If the reader of this message is not the
            intended recipient, or the employee or agent responsible for
            delivery of the message to the intended recipient, you are
            hereby notified that any dissemination, distribution or
            copying of this communication is strictly prohibited. If you
            have received this communication in error, please notify the
            sender immediately by e-mail and delete the material from
            any computer. Thank you. </p>
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    <p></p>
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      <div>
        <div><strong>Erika Pellegrini</strong></div>
        <div class="alpx">Research scientist</div>
        <div><a href="mailto:pellegrini@alpx-services.com"
            class="moz-txt-link-freetext">pellegrini@alpx-services.com</a></div>
        <a href="https://urldefense.com/v3/__https://alpx-services.com__;!!Mih3wA!FzbCyxktOWsrcEGGj8lRvJeFvqe6eGR9eRnNfq_OCAxDwIGPDLOd1jHlc6-_pvIOAorA46BZk0vYMHRa83yUNoxK_iQw$" class="moz-txt-link-freetext">https://alpx-services.com</a>
        <p> <a href="https://urldefense.com/v3/__https://alpx-services.com__;!!Mih3wA!FzbCyxktOWsrcEGGj8lRvJeFvqe6eGR9eRnNfq_OCAxDwIGPDLOd1jHlc6-_pvIOAorA46BZk0vYMHRa83yUNoxK_iQw$"><img
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              src="cid:part4.fQVme2Ag.Yc10SM8j@alpx-services.com" alt=""
              height="20px" border="0"> </a> </p>
        <div> 71 avenue des Martyrs <br>
          38000 Grenoble, France <br>
          Phone: +33476207967 </div>
        <br>
        <div class="small">
          <p> CONFIDENTIALITY NOTICE </p>
          <p> The information contained in this e-mail message is
            intended only for the exclusive use of the individual or
            entity named above and may contain information that is
            privileged, confidential or exempt from disclosure under
            applicable law. If the reader of this message is not the
            intended recipient, or the employee or agent responsible for
            delivery of the message to the intended recipient, you are
            hereby notified that any dissemination, distribution or
            copying of this communication is strictly prohibited. If you
            have received this communication in error, please notify the
            sender immediately by e-mail and delete the material from
            any computer. Thank you. </p>
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