<div dir="ltr"><div dir="ltr" class="gmail_signature" data-smartmail="gmail_signature"><div dir="ltr"><p>Dear 3DEM,</p>
<p>We are pleased to announce that CryoSPARC v4.6 has been released today with a number of updates. The full list is detailed in the changelog: <a href="https://urldefense.com/v3/__https://cryosparc.com/updates__;!!Mih3wA!F7lU4vnfrElwJu81J8p8v6YzBYEcNcmS0WkUZ0eunjKH0awGsb52dKqFjH72vArrFoNmUF33F1_Fogow9tdRWvVA$">https://cryosparc.com/updates</a></p>
<p>A few highlights:</p>
<ul>
<li>Up to 2.1x speedup across refinement and classification jobs. Homogeneous refinement of 2.3M particles (box size 300) now takes just 27 minutes on a single GPU.</li>
<li><a href="https://urldefense.com/v3/__https://guide.cryosparc.com/application-guide-v4.0*/job-views-cards-tree-and-table__;Kw!!Mih3wA!F7lU4vnfrElwJu81J8p8v6YzBYEcNcmS0WkUZ0eunjKH0awGsb52dKqFjH72vArrFoNmUF33F1_Fogow9lqEbMVw$">Tree, card, and table views</a> for jobs are rebuilt, with dramatic speedups to support large projects. Up to 10x faster load time for the tree view and nearly instant interactive updates.</li>
<li><a href="https://urldefense.com/v3/__https://guide.cryosparc.com/application-guide-v4.0*/job-views-cards-tree-and-table*job-groups__;KyM!!Mih3wA!F7lU4vnfrElwJu81J8p8v6YzBYEcNcmS0WkUZ0eunjKH0awGsb52dKqFjH72vArrFoNmUF33F1_Fogow9ke0g4-p$">New Job Groups</a> allow collapsing multiple jobs into a single card in order to organize, maintain legibility, and keep navigation easy for large projects. Job Groups work across all views, and can be made using multi-selection and the right-click menu.</li>
<li><a href="https://urldefense.com/v3/__https://guide.cryosparc.com/application-guide-v4.0*/interactive-jobs*auto-clustering__;KyM!!Mih3wA!F7lU4vnfrElwJu81J8p8v6YzBYEcNcmS0WkUZ0eunjKH0awGsb52dKqFjH72vArrFoNmUF33F1_Fogow9hCZdBe4$">Inspect Particle Picks</a> can now run without user intervention using a new Auto Cluster mode. Particles are clustered and automatically selected based on their NCC and power scores.</li>
</ul>
<p>Alongside the release, we are continually updating our educational materials and guides. Some recent items:</p>
<ul>
<li>Case Study: End-to-end processing of an inactive GPCR (EMPIAR-10668): We cover <a href="https://urldefense.com/v3/__https://guide.cryosparc.com/processing-data/tutorials-and-case-studies/case-study-end-to-end-processing-of-an-inactive-gpcr-empiar-10668__;!!Mih3wA!F7lU4vnfrElwJu81J8p8v6YzBYEcNcmS0WkUZ0eunjKH0awGsb52dKqFjH72vArrFoNmUF33F1_Fogow9rLYfS1A$">end to end processing for a 73 kDa membrane protein</a> through to generating maps ready for model building, as well as analyzing and separating states within a continuous motion.</li>
<li>Updated Guide Pages - Motion Correction: We have added a new <a href="https://urldefense.com/v3/__https://guide.cryosparc.com/processing-data/all-job-types-in-cryosparc/motion-correction__;!!Mih3wA!F7lU4vnfrElwJu81J8p8v6YzBYEcNcmS0WkUZ0eunjKH0awGsb52dKqFjH72vArrFoNmUF33F1_Fogow9qS1rbkL$">overview page</a> which explains why motion correction is important, the differences between various jobs and when each is appropriate, and the motivation behind dose weighting during motion correction. <a href="https://urldefense.com/v3/__https://guide.cryosparc.com/processing-data/all-job-types-in-cryosparc/motion-correction/job-patch-motion-correction__;!!Mih3wA!F7lU4vnfrElwJu81J8p8v6YzBYEcNcmS0WkUZ0eunjKH0awGsb52dKqFjH72vArrFoNmUF33F1_Fogow9mlwzHD4$">Patch Motion Correction</a> and the other job pages in this section have also been updated.</li>
</ul>
<p>For update instructions, please see: <a href="https://urldefense.com/v3/__https://guide.cryosparc.com/setup-configuration-and-management/software-updates__;!!Mih3wA!F7lU4vnfrElwJu81J8p8v6YzBYEcNcmS0WkUZ0eunjKH0awGsb52dKqFjH72vArrFoNmUF33F1_Fogow9ie0p6ga$">https://guide.cryosparc.com/setup-configuration-and-management/software-updates</a></p>
<p><br></p><p>Thank you!</p>
<div dir="ltr"><br></div>The CryoSPARC Team<br>Structura Biotechnology Inc.<br><a href="https://urldefense.com/v3/__http://cryosparc.com__;!!Mih3wA!F7lU4vnfrElwJu81J8p8v6YzBYEcNcmS0WkUZ0eunjKH0awGsb52dKqFjH72vArrFoNmUF33F1_Fogow9rCrUO2M$">cryosparc.com<br></a><a href="https://urldefense.com/v3/__http://structura.bio__;!!Mih3wA!F7lU4vnfrElwJu81J8p8v6YzBYEcNcmS0WkUZ0eunjKH0awGsb52dKqFjH72vArrFoNmUF33F1_Fogow9rXmjIPy$">structura.bio</a></div></div></div>