<html><head><meta http-equiv="content-type" content="text/html; charset=utf-8"></head><body style="overflow-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;"><div class="elementToProof" style="font-size: 12pt; margin-top: 0px; margin-bottom: 0px; font-family: "Times New Roman", Times, serif;">Dear colleagues,</div><div style="font-size: 12pt; margin: 0px; font-family: "Times New Roman", Times, serif;"> </div><div class="elementToProof" style="font-size: 12pt; margin: 0px; font-family: "Times New Roman", Times, serif;">We would like to bring your attention to this exciting meeting</div><div class="elementToProof" style="margin: 0px; font-family: "Times New Roman", Times, serif; font-size: 14pt; color: rgb(12, 100, 192);"><b><br></b></div><div class="elementToProof" style="margin: 0px; font-family: "Times New Roman", Times, serif; font-size: 14pt; color: rgb(12, 100, 192);"><b>Machines acting on DNA and RNA, a molecular mechanistic perspective</b></div><div class="elementToProof" style="margin: 0px; font-family: "Times New Roman", Times, serif; font-size: 14pt; color: rgb(12, 100, 192);"><b><br></b></div><div class="elementToProof" style="font-size: 12pt; margin: 0cm; font-family: "Times New Roman", Times, serif;">to take place at the <b>Spanish National Cancer Research Centre, CNIO</b> in Madrid, Spain,</div><div class="elementToProof" style="font-size: 12pt; margin: 0cm; font-family: "Times New Roman", Times, serif;"><b>May 28th – 30th, 2025.</b></div><div class="elementToProof" style="font-size: 12pt; margin: 0px; font-family: "Times New Roman", Times, serif;"><br></div><div class="elementToProof" style="font-size: 12pt; margin: 0px; font-family: "Times New Roman", Times, serif;">The purpose of the event is bringing together research leaders in the field with a focus on the integration of structural, biophysical and biochemical studies to define the molecular mechanisms underlying the function of the large molecular machines carrying out nucleic acid transactions essential for the cell and the organism.</div><div class="elementToProof" style="font-size: 12pt; margin: 0px; font-family: "Times New Roman", Times, serif;"><br></div><div class="elementToProof" style="font-size: 12pt; margin: 0px; font-family: "Times New Roman", Times, serif;">We will cover sessions about these topics:</div><div class="elementToProof" style="font-size: 12pt; margin: 0px; font-family: "Times New Roman", Times, serif;"><br></div><div style="margin: 0px; font-family: "Times New Roman", Times, serif; font-size: 11pt;"><b>Chromatin structure and remodelling</b></div><div style="margin: 0px; font-family: "Times New Roman", Times, serif; font-size: 11pt;"><b>DNA damage signalling and repair</b></div><div style="margin: 0px; font-family: "Times New Roman", Times, serif; font-size: 11pt;"><b>Macromolecular complexes in DNA / RNA processing</b></div><div style="margin: 0px; font-family: "Times New Roman", Times, serif; font-size: 11pt;"><b>Replication and Transcription</b></div><div class="elementToProof" style="margin: 0px; font-family: "Times New Roman", Times, serif; font-size: 11pt;"><b>Translation</b></div><div class="elementToProof" style="font-size: 12pt; margin: 0px; font-family: "Times New Roman", Times, serif;"><br></div><div class="elementToProof" style="font-size: 12pt; margin: 0px; font-family: "Times New Roman", Times, serif;"><u>INVITED SPEAKERS (Poster attached)</u></div><div class="elementToProof" style="font-size: 12pt; margin: 0px; font-family: "Times New Roman", Times, serif;"><br></div><div class="elementToProof" style="font-size: 12pt; margin: 0cm; font-family: "Times New Roman", Times, serif;"><b>Alexey Amunts</b> - Stockholm University, Sweden</div><div style="font-size: 12pt; margin: 0cm; font-family: "Times New Roman", Times, serif;"><b>James Berger</b> - Johns Hopkins School of Medicine, US</div><div style="font-size: 12pt; margin: 0cm; font-family: "Times New Roman", Times, serif;"><b>Elena Conti</b> - Max Plank – Biophysical Chemistry, Germany</div><div style="font-size: 12pt; margin: 0cm; font-family: "Times New Roman", Times, serif;"><b>Alessandro Costa</b> - The Francis Crick Institute, UK</div><div style="font-size: 12pt; margin: 0cm; font-family: "Times New Roman", Times, serif;"><b>Israel S. Fernández</b> - Biofisika Institute (CSIC-UPV/EHU), ES</div><div style="font-size: 12pt; margin: 0cm; font-family: "Times New Roman", Times, serif;"><b>Yuan He</b> - Johns Hopkins University, Baltimore, US</div><div style="font-size: 12pt; margin: 0cm; font-family: "Times New Roman", Times, serif;"><b>Cigall Kadoch</b> - Harvard Medical School, US</div><div style="font-size: 12pt; margin: 0cm; font-family: "Times New Roman", Times, serif;"><b>Elizabeth Kellogg</b> - St. Jude Children’s Research Hospital, Memphis, US</div><div style="font-size: 12pt; margin: 0cm; font-family: "Times New Roman", Times, serif;"><b>Meindert Lamers</b> - Leiden University Medical Center (LUMC), Netherlands</div><div style="font-size: 12pt; margin: 0cm; font-family: "Times New Roman", Times, serif;"><b>Jun-Jie (Gogo) Liu</b> - Tsinghua University, China</div><div style="font-size: 12pt; margin: 0cm; font-family: "Times New Roman", Times, serif;"><b>Karolin Luger</b> - University of Colorado Boulder, US</div><div style="font-size: 12pt; margin: 0cm; font-family: "Times New Roman", Times, serif;"><b>Kelly Nguyen</b> - MRC-LMB, UK</div><div style="font-size: 12pt; margin: 0cm; font-family: "Times New Roman", Times, serif;"><b>Lori Passmore</b> - MRC-LMB, UK</div><div style="font-size: 12pt; margin: 0cm; font-family: "Times New Roman", Times, serif;"><b>Anne Marie Pyle</b> - Yale University, US</div><div style="font-size: 12pt; margin: 0cm; font-family: "Times New Roman", Times, serif;"><b>Christian M T Spahn</b> - Institut für Medizinische Physik und Biophysik, Berlin, Germany</div><div style="font-size: 12pt; margin: 0cm; font-family: "Times New Roman", Times, serif;"><b>Alessandro Vannini</b> - Human Technopole, Italy</div><div style="font-size: 12pt; margin: 0cm; font-family: "Times New Roman", Times, serif;"><b>Wei Yang</b> - National Institutes of Health, NIH, US</div><div style="font-size: 12pt; margin: 0cm; font-family: "Times New Roman", Times, serif;"><b>Xiaodong Zhang</b> - Imperial College London, UK</div><div style="font-size: 12pt; margin: 0cm; font-family: "Times New Roman", Times, serif;"><b>Eva Nogales</b> - University of California Berkeley, HHMI, US</div><div style="font-size: 12pt; margin: 0cm; font-family: "Times New Roman", Times, serif;"><b>Oscar Llorca</b> - Spanish National Cancer Research Centre, Spain</div><div class="elementToProof" style="font-size: 12pt; margin: 0cm; font-family: "Times New Roman", Times, serif;"><b>Rafael Fernández Leiro</b> - Spanish National Cancer Research Centre, Spain</div><div class="elementToProof" style="font-size: 12pt; margin: 0px; font-family: "Times New Roman", Times, serif;"><br></div><div class="elementToProof" style="font-size: 12pt; margin: 0px; font-family: "Times New Roman", Times, serif;"> </div><div style="font-size: 12pt; margin: 0px; font-family: "Times New Roman", Times, serif;">The conference includes <b>poster sessions</b> and a significant number of <b>slots for short talks selected from the abstracts</b>.</div><div style="font-size: 12pt; margin: 0px; font-family: "Times New Roman", Times, serif;"> </div><div class="elementToProof" style="font-size: 12pt; margin: 0px; font-family: "Times New Roman", Times, serif;">The Organizing Committee encourages all those interested in structural biology of machines acting on DNA and RNA to apply, and </div><div class="elementToProof" style="font-size: 12pt; margin: 0px; font-family: "Times New Roman", Times, serif;">hear the latest developments in the field and also present their research.</div><div class="elementToProof" style="font-size: 12pt; margin: 0px; font-family: "Times New Roman", Times, serif;"><br></div><div style="font-size: 12pt; margin: 0px; font-family: "Times New Roman", Times, serif;"> </div><div style="font-size: 12pt; margin: 0px; font-family: "Times New Roman", Times, serif;">Application forms and instructions can be found at </div><div style="font-size: 12pt; margin: 0px; font-family: "Times New Roman", Times, serif;"> </div><div class="elementToProof" style="font-size: 12pt; margin: 0px; font-family: "Times New Roman", Times, serif;"><a href="https://www.cnio.es/en/eventos/machines-acting-on-dna-and-rna-a-molecular-mechanistic-perspective-2/" target="_blank" id="OWA3746273e-0d64-2c0b-da2a-47bdd1f6b2c9" class="OWAAutoLink" rel="noopener noreferrer" data-auth="NotApplicable" data-linkindex="21" style="margin: 0px;">https://www.cnio.es/en/eventos/machines-acting-on-dna-and-rna-a-molecular-mechanistic-perspective-2/</a></div><div style="font-size: 12pt; margin: 0px; font-family: "Times New Roman", Times, serif;"> </div><div style="font-size: 12pt; margin: 0px; font-family: "Times New Roman", Times, serif;"> </div><div style="font-size: 12pt; margin: 0px; font-family: "Times New Roman", Times, serif;">Looking forward to see you in Madrid,</div><div class="elementToProof" style="font-size: 12pt; margin: 0px; font-family: "Times New Roman", Times, serif;"><br></div><div class="elementToProof" style="font-size: 12pt; margin: 0px; font-family: "Times New Roman", Times, serif;">Eva Nogales, Rafael Fernández-Leiro, Oscar Llorca</div><div class="elementToProof" style="font-size: 12pt; margin: 0px; font-family: "Times New Roman", Times, serif;">The Organizing Committee</div><div style="font-size: 12pt; margin: 0px; font-family: "Times New Roman", Times, serif;"> </div><div>
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