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<p class="MsoNormal">Hi everyone,<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">We have a 3 year postdoc available in my lab to work on structure-guided design of proteins and peptides to modulate the human immune system.<br>
<br>
Briefly, we’ve used cryoEM to image various proteins “caught in the act” of immune defence, and have discovered that a protein called CRP forms molecular patterns on lipid membranes. The shape of these patterns dictates how our immune system will respond –
from inflammation to silent clearance to inhibition. Control of these patterns enables control of our immune system; this project will explore methods to gain control, with an eye on future therapeutic applications.<br>
<br>
The School of Biochemistry, and Bristol in general, are great places to work. We have access to high-end cryoEM and state-of-the-art facilities, a fantastic network of structural and synthetic biologists, contacts with industrial partners, and lots of exciting
collaborations to get involved with.<br>
<br>
<o:p></o:p></p>
<p class="MsoNormal">The advert is here: <o:p></o:p></p>
<p class="MsoNormal"><a href="https://urldefense.com/v3/__https://www.bristol.ac.uk/jobs/find/details/?jobId=353475&jobTitle=Research*20Associate*20*2F*20Senior*20Research*20Associate*20in*20Structure-Guided*20Drug*20Design__;JSUlJSUlJSUlJQ!!Mih3wA!GszsT5sTSuKutfjC84R9iBP_V3oR6cWTCX1LzqlAYaoCDZoTWt5A4JcK2dUABTcSz7A_Eu4uZnG8dj5jAjKSFkY$">https://www.bristol.ac.uk/jobs/find/details/?jobId=353475&jobTitle=Research%20Associate%20%2F%20Senior%20Research%20Associate%20in%20Structure-Guided%20Drug%20Design</a><o:p></o:p></p>
<p class="MsoNormal"><br>
And more information on the position is available in this pdf:<br>
<a href="https://urldefense.com/v3/__https://emea3.recruitmentplatform.com/tlk/pages/fo/download_job_file.jsp?ID=Q50FK026203F3VBQBV7V77V83&nDocumentID=4079599&ptId=353475__;!!Mih3wA!GszsT5sTSuKutfjC84R9iBP_V3oR6cWTCX1LzqlAYaoCDZoTWt5A4JcK2dUABTcSz7A_Eu4uZnG8dj5jlvmnNXY$">https://emea3.recruitmentplatform.com/tlk/pages/fo/download_job_file.jsp?ID=Q50FK026203F3VBQBV7V77V83&nDocumentID=4079599&ptId=353475</a><o:p></o:p></p>
<p class="MsoNormal"><br>
Experience with cryoEM is required, and experience with protein/peptide design, peptide synthesis, and/or protein expression is beneficial.<o:p></o:p></p>
<p class="MsoNormal"><br>
I’m very happy to be contacted for informal questions about the project<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">Please send this email on to anyone you think might be interested!<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
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<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:black;background:white;mso-ligatures:none;mso-fareast-language:EN-GB">All the best,<o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:black;background:white;mso-ligatures:none;mso-fareast-language:EN-GB"><o:p> </o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:black;background:white;mso-ligatures:none;mso-fareast-language:EN-GB">Thom<o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Calibri",sans-serif;color:black;background:white;mso-ligatures:none;mso-fareast-language:EN-GB"><o:p> </o:p></span></p>
<p class="MsoNormal" style="background:white"><b><span style="font-family:"Calibri",sans-serif;color:#3A3A3A;background:white;mso-ligatures:none">Dr. Thomas H. Sharp</span></b><b><span style="font-size:12.0pt;font-family:"Calibri",sans-serif;color:#3A3A3A;background:white;mso-ligatures:none"><br>
</span></b><span style="font-size:10.0pt;font-family:"Calibri",sans-serif;color:#747474;background:white;mso-ligatures:none">Associate Professor</span><b><span style="font-size:12.0pt;font-family:"Calibri",sans-serif;color:#3A3A3A;background:white;mso-ligatures:none"><br>
</span></b><span style="font-size:10.0pt;font-family:"Calibri",sans-serif;color:#747474;background:white;mso-ligatures:none">Room C101b, School of Biochemistry,
</span><span style="font-size:10.0pt;font-family:"Calibri",sans-serif;color:#747474;mso-ligatures:none">University of Bristol, BS8 1TD, UK<br>
Tel: +44 (0)117 455 2024<br>
Email: <a href="mailto:t.sharp@bristol.ac.uk"><span style="color:#467886">t.sharp@bristol.ac.uk</span></a><br>
</span><span style="font-size:12.0pt;color:black;mso-ligatures:none"><img border="0" width="166" height="50" style="width:1.7291in;height:.5208in" id="Picture_x0020_1" src="cid:image001.png@01DADC46.A5F0E3E0" alt="signature_4039223292"></span><o:p></o:p></p>
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