<html xmlns:v="urn:schemas-microsoft-com:vml" xmlns:o="urn:schemas-microsoft-com:office:office" xmlns:w="urn:schemas-microsoft-com:office:word" xmlns:m="http://schemas.microsoft.com/office/2004/12/omml" xmlns="http://www.w3.org/TR/REC-html40"><head><META HTTP-EQUIV="Content-Type" CONTENT="text/html; charset=us-ascii"><meta name=Generator content="Microsoft Word 15 (filtered medium)"><style><!--
/* Font Definitions */
@font-face
{font-family:"Cambria Math";
panose-1:2 4 5 3 5 4 6 3 2 4;}
@font-face
{font-family:Aptos;}
/* Style Definitions */
p.MsoNormal, li.MsoNormal, div.MsoNormal
{mso-margin-top-alt:auto;
margin-right:0in;
mso-margin-bottom-alt:auto;
margin-left:0in;
font-size:11.0pt;
font-family:"Aptos",sans-serif;
mso-ligatures:standardcontextual;}
a:link, span.MsoHyperlink
{mso-style-priority:99;
color:#467886;
text-decoration:underline;}
span.EmailStyle17
{mso-style-type:personal-compose;
font-family:"Aptos",sans-serif;
color:windowtext;}
.MsoChpDefault
{mso-style-type:export-only;
font-size:11.0pt;}
.MsoPapDefault
{mso-style-type:export-only;
mso-margin-top-alt:auto;
mso-margin-bottom-alt:auto;}
@page WordSection1
{size:8.5in 11.0in;
margin:1.0in 1.0in 1.0in 1.0in;}
div.WordSection1
{page:WordSection1;}
--></style><!--[if gte mso 9]><xml>
<o:shapedefaults v:ext="edit" spidmax="1026" />
</xml><![endif]--><!--[if gte mso 9]><xml>
<o:shapelayout v:ext="edit">
<o:idmap v:ext="edit" data="1" />
</o:shapelayout></xml><![endif]--></head><body lang=EN-US link="#467886" vlink="#96607D" style='word-wrap:break-word'><div class=WordSection1><p class=MsoNormal><span style='color:#323232'>Do you have a conundrum that knowing a structure might solve? HTI helps accelerate structure-based drug design/discovery (SBDD) with Cryo-EM structure determination services and AI-based software. Cryo-EM is a powerful technology for determining high-resolution 3-D structures of biological macromolecules and bound compounds. It applies broadly across the SBDD landscape, from complex proteins and small-molecule-based drugs, to mRNA, lipid nanoparticles, and vaccines. Our scientists and image processing experts work with your samples and experts to determine the structural conformations of your targets and leads.</span><o:p></o:p></p><p class=MsoNormal>HTI provides access to protein production, cryo-EM resources and expertise in a fast, affordable, and scalable way. We are also developing AI based software to automate and improve the image acquisition pipeline. By employing our solutions with your science expertise our goal is to improve your time to market for new drugs. More info at <a href="https://urldefense.com/v3/__https://hti.ai/services/__;!!Mih3wA!GaulOB-1elPI4e5eUFuhFbUcvf4vCW8MEwC-1GWhjzhVqO4jb3qEyOM2LS4gOfRTccXwp2ptB4Wowg$" target="_blank">Services - Health Technology Innovations, Inc. (hti.ai)</a><o:p></o:p></p><p class=MsoNormal><span style='color:#323232'>If you already have your own Cryo-EM resources, our proprietary software CryoFAST™ utilizes artificial intelligence to automate and accelerate your workflow. Early access to CryoFAST™ is now available </span><a href="https://urldefense.com/v3/__https://hti.ai/cryofast/__;!!Mih3wA!GaulOB-1elPI4e5eUFuhFbUcvf4vCW8MEwC-1GWhjzhVqO4jb3qEyOM2LS4gOfRTccXwp2rseoAUgw$" target="_blank">CryoFast™ - Fast Acquisition for Single Particle & Tomography - Health Technology Innovations, Inc. (hti.ai)</a>. <o:p></o:p></p><p class=MsoNormal><span style='color:#323232'>It would be great to show you how we can add value to your SBDD efforts.</span><o:p></o:p></p><p class=MsoNormal><span style='color:#323232'>For inquiry, pls contact <a href="mailto:info@hti.ai" target="_blank">info@hti.ai</a></span><o:p></o:p></p><p class=MsoNormal style='margin:0in'><span style='font-size:10.0pt;mso-ligatures:none'><o:p> </o:p></span></p><p class=MsoNormal><o:p> </o:p></p></div></body></html>