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Dear membrane-protein aficionados, <br>
<br>
I am happy to announce a major update of the detbelt server:
<a class="moz-txt-link-freetext" href="https://urldefense.com/v3/__https://detbelt.ibcp.fr/__;!!Mih3wA!AdQOZEzWtE7OLkJfU-0kcSqWExJKXq2k0v_FhcIhhYvpWojPaLbQrdTuyS0K-el-FW6ODYVRTcBWf6O_vjhJC1pX0O2LoQ$">https://detbelt.ibcp.fr/</a><br>
This server has been created to represent the bulk occupied by
amphipathic molecules around a membrane protein. <br>
<br>
* A database has been created with many entries from the OPM server
and Stephen White database; you may thus enter a pdb code or search
by keyword (i.e. GPCR, or ATP, or Kir6.2,…).<br>
Alternatively you can also submit your own pdb (ensuring that it is
already oriented using the OPM server). <br>
<br>
* Videos have been made on the tutorial webpage to explain how to
use the server, what to expect in outputs, the choice of the hollow
cylinder representation, etc..: <a class="moz-txt-link-freetext" href="https://urldefense.com/v3/__https://detbelt.ibcp.fr/tutorial__;!!Mih3wA!AdQOZEzWtE7OLkJfU-0kcSqWExJKXq2k0v_FhcIhhYvpWojPaLbQrdTuyS0K-el-FW6ODYVRTcBWf6O_vjhJC1q5B9ALxg$">https://detbelt.ibcp.fr/tutorial</a><br>
Introduction video: <a class="moz-txt-link-freetext" href="https://urldefense.com/v3/__https://www.youtube.com/watch?v=fVdk9QfpZt0__;!!Mih3wA!AdQOZEzWtE7OLkJfU-0kcSqWExJKXq2k0v_FhcIhhYvpWojPaLbQrdTuyS0K-el-FW6ODYVRTcBWf6O_vjhJC1pTOtBGfQ$">https://www.youtube.com/watch?v=fVdk9QfpZt0</a><br>
<br>
* A new Chimera button has been introduced allowing you to download
a script to represent the detergent belt in ChimeraX (attached
picture).<br>
<br>
The purpose of Detbelt is to be a tool for biochemists, to better
handle your sample. Last time it was useful for me was when I
optimized the lipid:protein ratio for reconstitution experiments.
Should I use 500 lipids, 5000 or 50,000? Depending on your needs,
Detbelt will give you in 2 minutes the idea of what the sample might
look like and guide your choice. <br>
<br>
All submissions to the server are anonymous. <br>
Don’t hesitate to contact me in case of problem, or if you think
another functionality should be added. <br>
<br>
Best regards<br>
Vincent Chaptal<br>
<br>
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<p class="p1"><span class="s1">Vincent Chaptal, PhD</span></p>
<p class="p1"><span class="s1">Director of GdR APPICOM</span></p>
<p class="p1"><span class="s1">Drug Resistance and Membrane
Proteins Lab</span></p>
<p class="p2"><span class="s1"></span><br>
</p>
<p class="p1"><span class="s1">MMSB -UMR5086</span></p>
<p class="p1"><span class="s1">7 passage du Vercors<span
class="Apple-converted-space"> </span></span></p>
<p class="p1"><span class="s1">69007 LYON</span></p>
<p class="p1"><span class="s1">FRANCE</span></p>
<p class="p1"><span class="s1">+33 4 37 65 29 01</span></p>
<p class="p1"><span class="s1"><a class="moz-txt-link-freetext" href="https://urldefense.com/v3/__http://www.appicom.cnrs.fr__;!!Mih3wA!AdQOZEzWtE7OLkJfU-0kcSqWExJKXq2k0v_FhcIhhYvpWojPaLbQrdTuyS0K-el-FW6ODYVRTcBWf6O_vjhJC1peev4_pw$">http://www.appicom.cnrs.fr</a></span></p>
<p class="p1"><span class="s1"><a class="moz-txt-link-freetext" href="https://urldefense.com/v3/__http://mmsb.cnrs.fr/en/__;!!Mih3wA!AdQOZEzWtE7OLkJfU-0kcSqWExJKXq2k0v_FhcIhhYvpWojPaLbQrdTuyS0K-el-FW6ODYVRTcBWf6O_vjhJC1qyjmeXCA$">http://mmsb.cnrs.fr/en/</a></span></p>
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