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<p class="MsoNoSpacing"><span style="font-size:11.0pt;font-family:"Times New Roman",serif;color:black">Dear All,</span><span style="font-size:11.0pt;font-family:"Times New Roman",serif;color:black"><o:p></o:p></span></p>
<p class="MsoNoSpacing"><span style="font-size:11.0pt;font-family:"Times New Roman",serif;color:black"><o:p> </o:p></span></p>
<p class="MsoNoSpacing"><span style="font-size:11.0pt;font-family:"Times New Roman",serif;color:black">I am excited to let you know that the Arimura Lab (launched in February 2024 in Basic Sciences Division, Fred Hutch Cancer Center, Seattle, WA, USA) is looking
for a Postdoctoral Fellow to help establish </span><span style="font-size:11.0pt;font-family:"Times New Roman",serif">an inclusive, diverse, innovative, and collaborative research team.<o:p></o:p></span></p>
<p class="MsoNoSpacing"><span style="font-size:11.0pt;font-family:"Times New Roman",serif"><o:p> </o:p></span></p>
<p class="MsoNoSpacing"><span style="font-size:11.0pt;font-family:"Times New Roman",serif">The successful candidate must have
<b>a keen interest in chromatin biology</b> and <b>the courage to develop novel approaches.
</b>We are particularly interested in <b>combining structural biology and genomics approaches</b>.<span style="color:black"><o:p></o:p></span></span></p>
<p class="MsoNoSpacing"><span style="font-size:11.0pt;font-family:"Times New Roman",serif;color:black"><o:p> </o:p></span></p>
<p class="MsoNoSpacing"><span style="font-size:11.0pt;font-family:"Times New Roman",serif">The mission of the Arimura Lab is to elucidate the regulation mechanisms of biological events occurring in eukaryotic chromosomes. Our Lab will accomplish this elucidation
by developing novel approaches. The lab currently possesses unique technology to determine the high-resolution cryo-EM structures of chromatin-related complexes isolated from interphase and M phase chromosomes formed in
<i>Xenopus</i> (frog) egg extract (PMID: 34478647) and <u>Mag</u>netic <u>I</u>solation and
<u>C</u>oncentration (MagIC)-cryo-EM, a technique enabling direct structural analysis of targets captured on nanomagnetic beads, which allows for the structural determination of scarce macromolecules (< 0.0005 mg/mL) in heterogeneous samples (PMID: 38328033
[preprint]). <span style="color:black"><o:p></o:p></span></span></p>
<p class="MsoNoSpacing"><b><span style="font-size:11.0pt;font-family:"Times New Roman",serif;color:black"><o:p> </o:p></span></b></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Times New Roman",serif;color:black">The fellow will either work on implementing our unique technologies or further advancing them (e.g. combining them with genomics, applying these technologies
to tissue culture cells) to elucidate the structural basis of the biological events occurring in eukaryotic chromosomes</span><span style="font-size:11.0pt;font-family:"Times New Roman",serif">, such as the transcription regulation in euchromatin and heterochromatin,
the mitosis-specific mechanisms that compact chromosomes and assemble kinetochores, and the accessible chromatin formation around transcription start site<span style="color:black">.<o:p></o:p></span></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Times New Roman",serif;color:black"><o:p> </o:p></span></p>
<p class="MsoNoSpacing"><span style="font-size:11.0pt;font-family:"Times New Roman",serif;color:black">The Arimura Lab provides a supportive environment that strongly emphasizes individualized mentoring. Upon joining, we will prioritize your continued development
as an independent scientist. We will collaborate with you to identify and develop plans to achieve your research and professional development goals. In addition, Fred Hutch and the Basic Sciences Division offer numerous career development opportunities, benefits,
and competitive salaries (starting at approximately $68k, with scheduled raises to ~$91k by 2027) for postdoctoral fellows.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Times New Roman",serif;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Times New Roman",serif;color:black">Please visit the following link to learn more.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Times New Roman",serif;color:black"><a href="https://urldefense.com/v3/__https://careers-fhcrc.icims.com/jobs/27135/post-doctoral-research-fellow---arimura-lab/job__;!!Mih3wA!BmNJesCYmKZMDBmtHc80O52BRF2NJc2MDksb_qiX0OZbv6NFjIuQSoSexoof6TcSUZe2gaLzKAJeaVpqhRVjL4I$">https://careers-fhcrc.icims.com/jobs/27135/post-doctoral-research-fellow---arimura-lab/job</a><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Times New Roman",serif;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Times New Roman",serif;color:black">Best Regards,<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Times New Roman",serif;mso-ligatures:none">Yasu Arimura<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Times New Roman",serif;mso-ligatures:none"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Times New Roman",serif;mso-ligatures:none"><a href="mailto:yarimura@fredhutch.org">yarimura@fredhutch.org</a></span><span style="font-size:11.0pt;font-family:"Times New Roman",serif;mso-ligatures:none;mso-fareast-language:JA"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Times New Roman",serif;mso-ligatures:none">Assistant Professor, Basic Sciences Division</span><span style="font-size:11.0pt;font-family:"Times New Roman",serif;mso-ligatures:none;mso-fareast-language:JA"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Times New Roman",serif;mso-ligatures:none">Fred Hutchinson Cancer Center<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Times New Roman",serif;mso-ligatures:none">1100 Fairview Ave N,<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Times New Roman",serif;mso-ligatures:none">Seattle, WA 98109<o:p></o:p></span></p>
<p class="MsoNormal"><o:p> </o:p></p>
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