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<p class="MsoNormal">Dear all,<o:p></o:p></p>
<p class="MsoNormal">A friendly reminder of the <b>deadline - </b><b>25th February 2024 -
</b>for the postdoc position on <b><span style="letter-spacing:-.1pt">androgen receptor antagonists</span>.<o:p></o:p></b></p>
<p class="MsoNormal">Best,<o:p></o:p></p>
<p class="MsoNormal">Peijun <o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<div>
<div style="border:none;border-top:solid #E1E1E1 1.0pt;padding:3.0pt 0cm 0cm 0cm">
<p class="MsoNormal"><b><span lang="EN-US" style="mso-ligatures:none">From:</span></b><span lang="EN-US" style="mso-ligatures:none"> Peijun Zhang
<br>
<b>Sent:</b> Monday, February 19, 2024 2:30 AM<br>
<b>To:</b> 3dem@ncmir.ucsd.edu; CCPEM@JISCMAIL.AC.UK<br>
<b>Subject:</b> postdoc position available in Peijun Zhang's group at Diamond Light Source, UK<o:p></o:p></span></p>
</div>
</div>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoPlainText"><a name="_Hlk526810490"><b>Postdoctoral Research Associate in eBIC –
<span style="letter-spacing:-.1pt">Characterization of androgen receptor antagonists</span><o:p></o:p></b></a></p>
<p class="TextBody" style="margin-bottom:0cm"><span style="mso-bookmark:_Hlk526810490"><b><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#00000A">Harwell, Oxfordshire</span></b></span><span style="mso-bookmark:_Hlk526810490"><b><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:windowtext">,
UK</span></b></span><span style="mso-bookmark:_Hlk526810490"><b><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#00000A"><o:p></o:p></span></b></span></p>
<p class="MsoBodyText" style="margin-bottom:0cm"><span style="mso-bookmark:_Hlk526810490"><b><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:windowtext">Salary
</span></b></span><span style="mso-bookmark:_Hlk526810490"><b><span style="font-size:11.0pt;font-family:"Calibri",sans-serif">£37,087 to £40,754 per annum (Discretionary range to £46,868).<o:p></o:p></span></b></span></p>
<p class="MsoBodyText" style="margin-bottom:0cm"><span style="mso-bookmark:_Hlk526810490"><b><span style="font-family:"Calibri",sans-serif">Full time, fixed
</span></b></span><span style="mso-bookmark:_Hlk526810490"><b><span style="font-family:"Calibri",sans-serif;color:windowtext">2</span></b></span><span style="mso-bookmark:_Hlk526810490"><b><span style="font-family:"Calibri",sans-serif"> year</span></b></span><span style="mso-bookmark:_Hlk526810490"><b><span style="font-family:"Calibri",sans-serif;color:windowtext">s</span></b></span><span style="mso-bookmark:_Hlk526810490"><b><span style="font-family:"Calibri",sans-serif">
<o:p></o:p></span></b></span></p>
<p class="MsoBodyText" style="margin-bottom:0cm"><span style="mso-bookmark:_Hlk526810490"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:windowtext"><o:p> </o:p></span></span></p>
<p class="MsoBodyText" style="margin-bottom:0cm"><span style="mso-bookmark:_Hlk526810490"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:windowtext"><o:p> </o:p></span></span></p>
<p class="MsoBodyText" style="margin-bottom:0cm"><span style="mso-bookmark:_Hlk526810490"><b><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:windowtext">Deadline: 25th February 2024<o:p></o:p></span></b></span></p>
<p class="MsoPlainText"><span style="mso-bookmark:_Hlk526810490"><b><o:p> </o:p></b></span></p>
<p class="MsoPlainText"><span style="mso-bookmark:_Hlk526810490"></span><a href="https://urldefense.com/v3/__https://vacancies.diamond.ac.uk/vacancy/pdra-characterization-of-androgen-receptor-antagonists-549009.html__;!!Mih3wA!D1saFQ5g5JOaSzt6t9kKoTx4ZKtGyuNjR2X7Kd1tg4jxKxyTbLW1ZsL66lzavftqOACqTDSRL0Bb5vnbJ9BlGABIH3_d45pm$"><span style="mso-bookmark:_Hlk526810490">https://vacancies.diamond.ac.uk/vacancy/pdra-characterization-of-androgen-receptor-antagonists-549009.html</span><span style="mso-bookmark:_Hlk526810490"></span></a><span style="mso-bookmark:_Hlk526810490"><b><o:p></o:p></b></span></p>
<p class="MsoPlainText"><span style="mso-bookmark:_Hlk526810490"><b><o:p> </o:p></b></span></p>
<p class="MsoPlainText"><span style="mso-bookmark:_Hlk526810490"><b><o:p> </o:p></b></span></p>
<p class="MsoPlainText"><span style="mso-bookmark:_Hlk526810490">A postdoc position is available in Professor Zhang’s lab at the Electron Bio-Imaging Centre (eBIC), Diamond Light Source, UK. The post is funded by a DoD award on “Characterization of a novel
class of non-competitive androgen receptor antagonists”.<o:p></o:p></span></p>
<p class="MsoPlainText"><span style="mso-bookmark:_Hlk526810490"><o:p> </o:p></span></p>
<p class="MsoPlainText"><span style="mso-bookmark:_Hlk526810490">Castration-resistant prostate cancer (CRPC) is currently incurable and is the second leading cause of cancer death in American men. Androgen-independent activation of the androgen receptor (AR)
remains the major driving force leading to CRPC. Structural and functional analysis of a novel class of AR antagonists capable of inducing AR degradation in the nucleus may lead to new therapeutics for CRPC. The posts will take part in the collaborative team
research to understand the underlying molecular mechanisms of the inhibition and degradation of nuclear AR by this class of antagonists using structural biology approaches.<o:p></o:p></span></p>
<p class="MsoPlainText"><span style="mso-bookmark:_Hlk526810490"><o:p> </o:p></span></p>
<p class="MsoPlainText"><span style="mso-bookmark:_Hlk526810490">We are seeking highly motivated scientist to conduct high-resolution structural analysis of AR in complexes with its antagonists. The post is based in eBIC, the UK national cryoEM facility, which
provides scientists with state-of-the-art instruments and expertise in cryoEM. Currently eBIC houses five Titan Krios, a Talos Arctica, and two Glacios, two cryoFIB/SEM instruments (Scios and Aquilos 2), and a Leica cryoCLEM for correlative light and electron
microscopy (</span><a href="https://urldefense.com/v3/__https://www.diamond.ac.uk/Instruments/Biological-Cryo-Imaging/eBIC.html__;!!Mih3wA!D1saFQ5g5JOaSzt6t9kKoTx4ZKtGyuNjR2X7Kd1tg4jxKxyTbLW1ZsL66lzavftqOACqTDSRL0Bb5vnbJ9BlGABIH5346lbf$"><span style="mso-bookmark:_Hlk526810490">https://www.diamond.ac.uk/Instruments/Biological-Cryo-Imaging/eBIC.html</span><span style="mso-bookmark:_Hlk526810490"></span></a><span style="mso-bookmark:_Hlk526810490">).<o:p></o:p></span></p>
<p class="MsoPlainText"><span style="mso-bookmark:_Hlk526810490"><o:p> </o:p></span></p>
<p class="MsoPlainText"><span style="mso-bookmark:_Hlk526810490">You should have a PhD degree in structural biology or equivalent and have a demonstrated record of accomplishment in conducting high quality original research. Knowledge and research experience
in structural biology, including protein biochemistry and single particle cryoEM, are essential.<o:p></o:p></span></p>
<p class="MsoPlainText"><span style="mso-bookmark:_Hlk526810490"><o:p> </o:p></span></p>
<p class="MsoPlainText"><span style="mso-bookmark:_Hlk526810490"><span lang="EN">Applicants are required to outline their suitability for this role via the online application process and
</span>should include a CV, summary of their accomplishment and research interests, and publication list</span><span style="mso-bookmark:_Hlk526810490"><span lang="EN">.
<o:p></o:p></span></span></p>
<p class="MsoPlainText"><span style="mso-bookmark:_Hlk526810490"><span lang="EN"><o:p> </o:p></span></span></p>
<p class="MsoPlainText"><span style="mso-bookmark:_Hlk526810490"><strong><span style="font-family:"Calibri",sans-serif">The initial closing date for applications is 25th February 2024, however applications will be reviewed and interviewed on an ongoing basis
until this vacancy is filled.</span></strong></span><span style="mso-bookmark:_Hlk526810490"><span lang="EN"><o:p></o:p></span></span></p>
<p class="MsoPlainText"><span style="mso-bookmark:_Hlk526810490"><span lang="EN"><o:p> </o:p></span></span></p>
<p class="MsoPlainText"><span style="mso-bookmark:_Hlk526810490">For further information about this role please contact Peijun Zhang (</span><a href="mailto:peijun.zhang@diamond.ac.uk"><span style="mso-bookmark:_Hlk526810490">peijun.zhang@diamond.ac.uk</span><span style="mso-bookmark:_Hlk526810490"></span></a><span style="mso-bookmark:_Hlk526810490">).<o:p></o:p></span></p>
<p class="MsoPlainText"><span style="mso-bookmark:_Hlk526810490"><span lang="EN"><o:p> </o:p></span></span></p>
<p class="MsoPlainText"><span style="mso-bookmark:_Hlk526810490"><a name="_Hlk39506144"><span lang="EN">Other information
<o:p></o:p></span></a></span></p>
<p class="MsoPlainText"><span style="mso-bookmark:_Hlk526810490"><span style="mso-bookmark:_Hlk39506144"><span lang="EN">Diamond offers an exceptional benefits package to ensure an excellent work/life balance including 25 days’ annual leave, 13 days statutory
and company holidays, flexible working hours, an onsite nursery, an excellent pension scheme, and social and sporting activities.<o:p></o:p></span></span></span></p>
<ul type="disc">
<li class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l1 level1 lfo3">
<span style="mso-bookmark:_Hlk526810490"><span style="mso-bookmark:_Hlk39506144"></span></span><a href="https://urldefense.com/v3/__http://www.diamond.ac.uk/Careers/Company-Benefits.html__;!!Mih3wA!D1saFQ5g5JOaSzt6t9kKoTx4ZKtGyuNjR2X7Kd1tg4jxKxyTbLW1ZsL66lzavftqOACqTDSRL0Bb5vnbJ9BlGABIHx1ZDmXn$"><span style="mso-bookmark:_Hlk526810490"><span style="mso-bookmark:_Hlk39506144">Company benefits</span></span><span style="mso-bookmark:_Hlk526810490"><span style="mso-bookmark:_Hlk39506144"></span></span></a><span style="mso-bookmark:_Hlk526810490"><span style="mso-bookmark:_Hlk39506144"><o:p></o:p></span></span></li><li class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l1 level1 lfo3">
<span style="mso-bookmark:_Hlk526810490"><span style="mso-bookmark:_Hlk39506144"></span></span><a href="https://urldefense.com/v3/__http://www.diamond.ac.uk/Careers/Applicant-Information/LocalArea.html__;!!Mih3wA!D1saFQ5g5JOaSzt6t9kKoTx4ZKtGyuNjR2X7Kd1tg4jxKxyTbLW1ZsL66lzavftqOACqTDSRL0Bb5vnbJ9BlGABIH4zmF3Ej$"><span style="mso-bookmark:_Hlk526810490"><span style="mso-bookmark:_Hlk39506144">Life
at diamond</span></span><span style="mso-bookmark:_Hlk526810490"><span style="mso-bookmark:_Hlk39506144"></span></span></a><span style="mso-bookmark:_Hlk39506144"></span><span style="mso-bookmark:_Hlk526810490"><o:p></o:p></span></li></ul>
<p class="MsoNormal"><span style="mso-bookmark:_Hlk526810490"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="mso-bookmark:_Hlk526810490"><o:p> </o:p></span></p>
<p class="MsoNormal" style="margin-bottom:.5pt;background:white"><span style="mso-bookmark:_Hlk526810490"><b><span style="color:black;background:white;mso-ligatures:none;mso-fareast-language:EN-GB">Peijun Zhang<o:p></o:p></span></b></span></p>
<p class="MsoNormal" style="margin-bottom:.5pt"><span style="mso-bookmark:_Hlk526810490"><span style="font-size:10.0pt;mso-ligatures:none">Professor<o:p></o:p></span></span></p>
<p class="MsoNormal" style="margin-bottom:.5pt"><span style="mso-bookmark:_Hlk526810490"><span style="font-size:10.0pt;mso-ligatures:none">Division of Structural Biology<o:p></o:p></span></span></p>
<p class="MsoNormal" style="margin-bottom:.5pt"><span style="mso-bookmark:_Hlk526810490"><span style="font-size:10.0pt;mso-ligatures:none">Wellcome Trust Centre for Human Genetics<o:p></o:p></span></span></p>
<p class="MsoNormal" style="margin-bottom:.5pt"><span style="mso-bookmark:_Hlk526810490"><span style="font-size:10.0pt;mso-ligatures:none">University of Oxford<o:p></o:p></span></span></p>
<p class="MsoNormal" style="margin-bottom:.5pt"><span style="mso-bookmark:_Hlk526810490"><span style="font-size:10.0pt;mso-ligatures:none">Roosevelt Drive Oxford OX3 7BN, UK<o:p></o:p></span></span></p>
<p class="MsoNormal" style="margin-bottom:.5pt"><span style="mso-bookmark:_Hlk526810490"></span><a href="mailto:Peijun.zhang@strubi.ox.ac.uk"><span style="mso-bookmark:_Hlk526810490"><span style="font-size:10.0pt;color:blue;mso-ligatures:none">Peijun.zhang@strubi.ox.ac.uk</span></span><span style="mso-bookmark:_Hlk526810490"></span></a><span style="mso-bookmark:_Hlk526810490"><span style="font-size:10.0pt;mso-ligatures:none"><o:p></o:p></span></span></p>
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