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<p class="MsoNormal"><span lang="EN-US">Dear all,<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p style="mso-margin-top-alt:6.0pt;margin-right:0cm;margin-bottom:11.25pt;margin-left:0cm;background:white">
<span lang="EN-US" style="font-size:10.0pt;font-family:"Open Sans",sans-serif;color:#252525;letter-spacing:.25pt">We have 3</span><span style="font-size:10.0pt;font-family:"Open Sans",sans-serif;color:#252525;letter-spacing:.25pt"> postdoctoral positions available
in </span><span lang="EN-US" style="font-size:10.0pt;font-family:"Open Sans",sans-serif;color:#252525;letter-spacing:.25pt">my</span><span style="font-size:10.0pt;font-family:"Open Sans",sans-serif;color:#252525;letter-spacing:.25pt"> group</span><span style="font-size:10.0pt;font-family:"Open Sans",sans-serif;color:#252525;letter-spacing:.25pt">
</span><span style="font-size:10.0pt;font-family:"Open Sans",sans-serif;color:#252525;letter-spacing:.25pt">at the Novo Nordisk Foundation Center for Protein Research, University of Copenhagen. We aim to recruit scientists with extensive experience in one or
more of the techniques of interest to help pioneer and establish this new research field. The positions are for 2 years in the first instance and can be renewed for up to 4 years in total, providing a unique long-term opportunity to work on an exciting project
in a well-equipped and supportive environment.<o:p></o:p></span></p>
<p style="mso-margin-top-alt:6.0pt;margin-right:0cm;margin-bottom:11.25pt;margin-left:0cm;background:white">
<strong><span style="font-size:10.0pt;font-family:"Open Sans",sans-serif;color:#252525;letter-spacing:.25pt">Background</span></strong><span style="font-size:10.0pt;font-family:"Open Sans",sans-serif;color:#252525;letter-spacing:.25pt"><br>
Bacteria are under constant attack by bacteriophages, and have evolved intricate systems to tackle this constant threat (Doron et al, Science, 2018). We have a special focus on
</span><span lang="EN-US" style="font-size:10.0pt;font-family:"Open Sans",sans-serif;color:#252525;letter-spacing:.25pt">anti-</span><span style="font-size:10.0pt;font-family:"Open Sans",sans-serif;color:#252525;letter-spacing:.25pt">bacteriophage defense at
the bacterial cell envelope/membrane, for which we recently received a large Hallas Møller Ascending Investigator grant from the Novo Nordisk Foundation. We have been actively working on
</span><span lang="EN-US" style="font-size:10.0pt;font-family:"Open Sans",sans-serif;color:#252525;letter-spacing:.25pt">anti-</span><span style="font-size:10.0pt;font-family:"Open Sans",sans-serif;color:#252525;letter-spacing:.25pt">bacteriophage defense in
the past years with our first preprint </span><span lang="EN-US" style="font-size:10.0pt;font-family:"Open Sans",sans-serif;color:#252525;letter-spacing:.25pt">now online</span><span style="font-size:10.0pt;font-family:"Open Sans",sans-serif;color:#252525;letter-spacing:.25pt">
(Hu et al., <a href="https://urldefense.com/v3/__https://www.biorxiv.org/content/10.1101/2023.12.18.572097v1__;!!Mih3wA!Ep_AEcuqAPbGjaD_12OpcDBID0F9_wOfcdapbsK64JpUv0EcUmYFU1VILB2HdFOgQ2X0U60SBFsjeeTfXj0acCUvTDJyhwk$">
https://www.biorxiv.org/content/10.1101/2023.12.18.572097v1</a>).<o:p></o:p></span></p>
<p style="mso-margin-top-alt:6.0pt;margin-right:0cm;margin-bottom:11.25pt;margin-left:0cm;background:white;box-sizing: border-box">
<span style="font-size:10.0pt;font-family:"Open Sans",sans-serif;color:#252525;letter-spacing:.25pt">We will investigate defense systems using three approaches: single particle cryo-EM, cryo-electron tomography, and protein bioinformatics/design. Together with
expert collaborators in phage biology, engineering and light microscopy, we aim to unravel fundamentally novel mechanisms in
</span><span lang="EN-US" style="font-size:10.0pt;font-family:"Open Sans",sans-serif;color:#252525;letter-spacing:.25pt">anti-</span><span style="font-size:10.0pt;font-family:"Open Sans",sans-serif;color:#252525;letter-spacing:.25pt">bacteriophage defense and
biology.<o:p></o:p></span></p>
<p style="mso-margin-top-alt:6.0pt;margin-right:0cm;margin-bottom:11.25pt;margin-left:0cm;background:white;box-sizing: border-box">
<span style="font-size:10.0pt;font-family:"Open Sans",sans-serif;color:#252525;letter-spacing:.25pt">We are looking for three motivated postdocs with experience in one of the three approaches to help tackle this exciting challenge.<o:p></o:p></span></p>
<p style="mso-margin-top-alt:6.0pt;margin-right:0cm;margin-bottom:11.25pt;margin-left:0cm;background:white;box-sizing: border-box">
<span style="font-size:10.0pt;font-family:"Open Sans",sans-serif;color:#252525;letter-spacing:.25pt">Position 1<br>
The postdoc will be involved in the expression and purification of components of anti-bacteriophage defense systems interacting with the bacterial cell membrane. Using single particle cryo-electron microscopy, the postdoc will investigate the structure of these
systems in different states.<o:p></o:p></span></p>
<p style="mso-margin-top-alt:6.0pt;margin-right:0cm;margin-bottom:11.25pt;margin-left:0cm;background:white;box-sizing: border-box">
<span style="font-size:10.0pt;font-family:"Open Sans",sans-serif;color:#252525;letter-spacing:.25pt">Position 2<br>
The postdoc will study anti-bacteriophage defense systems interacting with the bacterial cell membrane using cryo-electron tomography. They will investigate how the defense systems are able to ward of bacteriophage infections.<o:p></o:p></span></p>
<p style="mso-margin-top-alt:6.0pt;margin-right:0cm;margin-bottom:11.25pt;margin-left:0cm;background:white;box-sizing: border-box">
<span style="font-size:10.0pt;font-family:"Open Sans",sans-serif;color:#252525;letter-spacing:.25pt">Position 3<br>
The postdoc will investigate anti-bacteriophage defense systems as well as phage-encoded inhibitors for these defense systems from a computational point of view. In particular, they will use structure prediction to predict novel defense systems and protein
design to design new defense systems.<o:p></o:p></span></p>
<p style="mso-margin-top-alt:6.0pt;margin-right:0cm;margin-bottom:11.25pt;margin-left:0cm;background:white;box-sizing: border-box">
<span style="font-size:10.0pt;font-family:"Open Sans",sans-serif;color:#252525;letter-spacing:.25pt"> </span><span lang="EN-US" style="font-size:10.0pt;font-family:"Open Sans",sans-serif;color:#252525;letter-spacing:.25pt">More info and apply here (deadline
</span><b><span style="font-size:10.0pt;font-family:"Open Sans",sans-serif;color:#252525;letter-spacing:.25pt">: January 8 2024, 23.59pm CET</span></b><b><span lang="EN-US" style="font-size:10.0pt;font-family:"Open Sans",sans-serif;color:#252525;letter-spacing:.25pt">)</span></b><span lang="EN-US" style="font-size:10.0pt;font-family:"Open Sans",sans-serif;color:#252525;letter-spacing:.25pt">:<o:p></o:p></span></p>
<p style="mso-margin-top-alt:6.0pt;margin-right:0cm;margin-bottom:11.25pt;margin-left:0cm;background:white">
<span lang="EN-US" style="font-size:10.0pt;font-family:"Open Sans",sans-serif;color:#252525;letter-spacing:.25pt"><a href="https://urldefense.com/v3/__https://employment.ku.dk/faculty/?show=160758__;!!Mih3wA!Ep_AEcuqAPbGjaD_12OpcDBID0F9_wOfcdapbsK64JpUv0EcUmYFU1VILB2HdFOgQ2X0U60SBFsjeeTfXj0acCUv87EYBZE$">https://employment.ku.dk/faculty/?show=160758</a><o:p></o:p></span></p>
<p style="mso-margin-top-alt:6.0pt;margin-right:0cm;margin-bottom:11.25pt;margin-left:0cm;background:white;box-sizing: border-box">
<span style="font-size:10.0pt;font-family:"Open Sans",sans-serif;color:#252525;letter-spacing:.25pt">If you have any questions about the positions, please contact: <a href="mailto:nicholas.taylor@cpr.ku.dk"><span style="color:#2C6694">nicholas.taylor@cpr.ku.dk</span></a>.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">Best wishes,<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US">Nicholas<o:p></o:p></span></p>
<p class="MsoNormal"><o:p> </o:p></p>
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<p class="MsoNormal"><span style="mso-ligatures:none;mso-fareast-language:EN-GB">-- <o:p></o:p></span></p>
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<p class="MsoNormal"><span style="mso-ligatures:none"><o:p> </o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:7.5pt;font-family:"Verdana",sans-serif;color:gray;mso-ligatures:none;mso-fareast-language:EN-GB"><br>
Nicholas M. I. Taylor, PhD</span></b><span style="color:black;mso-ligatures:none;mso-fareast-language:EN-GB"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:7.5pt;font-family:"Verdana",sans-serif;color:gray;mso-ligatures:none;mso-fareast-language:EN-GB">Associate Professor</span><span style="color:black;mso-ligatures:none;mso-fareast-language:EN-GB"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:7.5pt;font-family:"Verdana",sans-serif;color:gray;mso-ligatures:none;mso-fareast-language:EN-GB"> </span><span style="color:black;mso-ligatures:none;mso-fareast-language:EN-GB"><o:p></o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:7.5pt;font-family:"Verdana",sans-serif;color:gray;mso-ligatures:none;mso-fareast-language:EN-GB">University of Copenhagen</span></b><span style="color:black;mso-ligatures:none;mso-fareast-language:EN-GB"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:7.5pt;font-family:"Verdana",sans-serif;color:gray;mso-ligatures:none;mso-fareast-language:EN-GB">Faculty of Health and Medical Sciences</span><span style="color:black;mso-ligatures:none;mso-fareast-language:EN-GB"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:7.5pt;font-family:"Verdana",sans-serif;color:gray;mso-ligatures:none;mso-fareast-language:EN-GB">Novo Nordisk Foundation Center for Protein Research</span><span style="color:black;mso-ligatures:none;mso-fareast-language:EN-GB"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:7.5pt;font-family:"Verdana",sans-serif;color:gray;mso-ligatures:none;mso-fareast-language:EN-GB">Blegdamsvej 3B,
</span><span lang="DA" style="font-size:7.5pt;font-family:"Verdana",sans-serif;color:gray;mso-ligatures:none;mso-fareast-language:EN-GB">Office 6.1.14</span><span lang="DA" style="color:black;mso-ligatures:none;mso-fareast-language:EN-GB"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:7.5pt;font-family:"Verdana",sans-serif;color:gray;mso-ligatures:none;mso-fareast-language:EN-GB">2200 Copenhagen N</span><span style="color:black;mso-ligatures:none;mso-fareast-language:EN-GB"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:7.5pt;font-family:"Verdana",sans-serif;color:gray;mso-ligatures:none;mso-fareast-language:EN-GB">Denmark</span><span style="color:black;mso-ligatures:none;mso-fareast-language:EN-GB"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:7.5pt;font-family:"Verdana",sans-serif;color:gray;mso-ligatures:none;mso-fareast-language:EN-GB"> </span><span style="color:black;mso-ligatures:none;mso-fareast-language:EN-GB"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;color:black;mso-ligatures:none;mso-fareast-language:EN-GB"><a href="mailto:nicholas.taylor@cpr.ku.dk" title="mailto:nicholas.taylor@cpr.ku.dk"><span style="font-size:7.5pt;font-family:"Verdana",sans-serif;color:gray">nicholas.taylor@cpr.ku.dk</span></a></span><span style="color:black;mso-ligatures:none;mso-fareast-language:EN-GB"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;color:black;mso-ligatures:none;mso-fareast-language:EN-GB"><a href="https://urldefense.com/v3/__http://www.cpr.ku.dk__;!!Mih3wA!Ep_AEcuqAPbGjaD_12OpcDBID0F9_wOfcdapbsK64JpUv0EcUmYFU1VILB2HdFOgQ2X0U60SBFsjeeTfXj0acCUvk-walZM$" title="http://www.cpr.ku.dk/"><span style="font-size:7.5pt;font-family:"Verdana",sans-serif;color:gray">http://www.cpr.ku.dk</span></a></span><span style="color:black;mso-ligatures:none;mso-fareast-language:EN-GB"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:7.5pt;font-family:"Verdana",sans-serif;color:black;mso-ligatures:none;mso-fareast-language:EN-GB"> </span><span style="color:black;mso-ligatures:none;mso-fareast-language:EN-GB"><o:p></o:p></span></p>
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