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<p class="MsoNormal"><b><span style="font-size:14.0pt;color:#0070C0">Senior Staff Scientist Position Available in the FIB-SEM Collaboration Core
</span></b><span style="font-size:14.0pt;color:#333333;background:white">(<a href="https://urldefense.com/v3/__https://medicine.yale.edu/fib-sem/__;!!Mih3wA!HZC6bDAMfDhiVoDymy02fG52JAR6MPT_vmKyFnYG4tf_lhEvwaAl7lC95hJq0Mi5UXxMwy8NkxalGoSr0sUn_Yw$">https://medicine.yale.edu/fib-sem/</a>)</span>
<b><span style="font-size:14.0pt;color:#0070C0">of Yale School of Medicine at Yale University</span></b><span style="font-size:14.0pt;color:#212121"><br>
</span><span style="font-size:13.5pt;font-family:"Georgia",serif;color:#212121"><br>
</span><b><span style="font-size:14.0pt;color:#212121">The FIB-SEM Collaboration Core (F-SCC) of Yale School Medicine (CT, USA) is looking for a talented, skillful, and highly motivated researcher to fill the<span class="apple-converted-space"> <span style="background:aqua;mso-highlight:aqua">Senior
</span></span><span style="background:aqua;mso-highlight:aqua">Staff Scientist</span><span class="apple-converted-space"> </span>position to lead
</span></b><b><span style="font-size:14.0pt;color:#333333;background:white">electron microscopy (EM) sample preparation lab within
</span></b><b><span style="font-size:14.0pt;color:#212121">FIB-SEM Collaboration Core.<o:p></o:p></span></b></p>
<p class="MsoNormal"><span style="font-family:"Aptos",sans-serif;color:#212121"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt;color:#212121">For consideration, please submit an application and cover letter describing how your previous research accomplishments and scientific interests fit with the scope of the research via this
<b><span style="background:aqua;mso-highlight:aqua"><a href="https://urldefense.com/v3/__https://sjobs.brassring.com/TGnewUI/Search/home/HomeWithPreLoad?PageType=JobDetails&partnerid=25053&siteid=5248&Areq=85505BR*jobDetails=1582564_5248__;Iw!!Mih3wA!HZC6bDAMfDhiVoDymy02fG52JAR6MPT_vmKyFnYG4tf_lhEvwaAl7lC95hJq0Mi5UXxMwy8NkxalGoSrtnsCeNM$">link</a></span></b>.
<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:6.0pt"><span style="font-size:13.5pt;font-family:"Georgia",serif;color:#212121"><br>
</span><b><span style="font-size:14.0pt">Position Focus</span></b><b><span style="font-size:14.0pt;color:#333333"><o:p></o:p></span></b></p>
<p class="MsoNormal" style="text-align:justify;text-justify:inter-ideograph"><span style="color:#333333">At the forefront of volume Electron Microscopy, the F-SCC utilizes the state of the art enhanced Focused Ion Beam Scanning Electron Microscopy (FIB-SEM)
technology for large volume imaging with nanometer isotropic resolution. Under supervision of the Director of F-SCC, the candidate will play a leadership role in managing electron microscopy (EM) sample preparation lab within F-SCC. Explicitly, the candidate
will be responsible for optimizing the existing electron microscopy (EM) sample preparation protocols of biological specimens and developing new methods for clinical specimens. The candidate is expected to perform independent research, experiments, and laboratory
techniques, and work closely with supervisor, internal and external collaborators, and group members. Responsible for the daily operation of EM sample preparation lab within F-SCC, and related data analysis for research projects.
<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify;text-justify:inter-ideograph"><span style="color:#333333"><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-align:justify;text-justify:inter-ideograph"><span style="color:#333333">While the job duty will evolve according to the needs of the organization, specific responsibilities include:<o:p></o:p></span></p>
<ul style="margin-top:0in" type="disc">
<li class="MsoListParagraphCxSpFirst" style="color:#333333;margin-bottom:8.0pt;margin-left:-.25in;mso-add-space:auto;text-align:justify;text-justify:inter-ideograph;line-height:106%;mso-list:l0 level1 lfo1">
Carry out work requests using EM sample preparation methods with heavy metal staining and resin embedding, followed by transmission electron microscopy (TEM) imaging to evaluate sample quality. Perform transcardial perfusion on animal as needed.<o:p></o:p></li><li class="MsoListParagraphCxSpMiddle" style="color:#333333;margin-bottom:8.0pt;margin-left:-.25in;mso-add-space:auto;text-align:justify;text-justify:inter-ideograph;line-height:106%;mso-list:l0 level1 lfo1">
Optimize the existing electron microscopy (EM) sample preparation protocols of biological specimens.<o:p></o:p></li><li class="MsoListParagraphCxSpMiddle" style="color:#333333;margin-bottom:8.0pt;margin-left:-.25in;mso-add-space:auto;text-align:justify;text-justify:inter-ideograph;line-height:106%;mso-list:l0 level1 lfo1">
Develop new methods for clinical specimens.<o:p></o:p></li><li class="MsoListParagraphCxSpMiddle" style="color:#333333;margin-bottom:8.0pt;margin-left:-.25in;mso-add-space:auto;text-align:justify;text-justify:inter-ideograph;line-height:106%;mso-list:l0 level1 lfo1">
Develop automated EM sample preparation pipeline.<o:p></o:p></li><li class="MsoListParagraphCxSpMiddle" style="color:#333333;margin-bottom:8.0pt;margin-left:-.25in;mso-add-space:auto;text-align:justify;text-justify:inter-ideograph;line-height:106%;mso-list:l0 level1 lfo1">
Participate in FIB-SEM sample preparation including sample mounting and targeting to specific region of interest using ultramicrotome guided by x-ray micro-CT.
<o:p></o:p></li><li class="MsoListParagraphCxSpLast" style="color:#333333;margin-left:-.25in;mso-add-space:auto;text-align:justify;text-justify:inter-ideograph;line-height:107%;mso-list:l0 level1 lfo1">
Explore new methods to support the advances in volume electron microscopy.<o:p></o:p></li></ul>
<p class="MsoNormal" style="margin-bottom:6.0pt"><b><span style="font-size:14.0pt"><o:p> </o:p></span></b></p>
<p class="MsoNormal" style="margin-bottom:6.0pt"><b><span style="font-size:14.0pt">Essential Duties:<o:p></o:p></span></b></p>
<ol style="margin-top:0in" start="1" type="1">
<li class="MsoListParagraphCxSpFirst" style="color:#666666;margin-left:0in;mso-add-space:auto;line-height:18.0pt;mso-list:l2 level1 lfo2;background:white;vertical-align:baseline">
<span style="mso-ligatures:none">Carries out the wide range of specialized scientific methods and procedures used in the laboratory.<o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="color:#666666;margin-left:0in;mso-add-space:auto;line-height:18.0pt;mso-list:l2 level1 lfo2;background:white;vertical-align:baseline">
<span style="mso-ligatures:none">Responsible for resource planning, allocation, and planning renovations. Determines, develops, and implements the operative framework of the laboratory as it relates to long-term goals, needs, and direction.<o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="color:#666666;margin-left:0in;mso-add-space:auto;line-height:18.0pt;mso-list:l2 level1 lfo2;background:white;vertical-align:baseline">
<span style="mso-ligatures:none">Keeps abreast of newly-evolving technologies, instrumentation, and methodologies and purchases new instrumentation.<o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="color:#666666;margin-left:0in;mso-add-space:auto;line-height:18.0pt;mso-list:l2 level1 lfo2;background:white;vertical-align:baseline">
<span style="mso-ligatures:none">Develops, analyzes, interprets, and summarizes scientific results.<o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="color:#666666;margin-left:0in;mso-add-space:auto;line-height:18.0pt;mso-list:l2 level1 lfo2;background:white;vertical-align:baseline">
<span style="mso-ligatures:none">Establishes policies and procedures governing operation of the laboratory.<o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="color:#666666;margin-left:0in;mso-add-space:auto;line-height:18.0pt;mso-list:l2 level1 lfo2;background:white;vertical-align:baseline">
<span style="mso-ligatures:none">Independently investigates and solves biotechnological problems as they arise through research and extensive literary searches. Determines subsequent experimental approaches.<o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="color:#666666;margin-left:0in;mso-add-space:auto;line-height:18.0pt;mso-list:l2 level1 lfo2;background:white;vertical-align:baseline">
<span style="mso-ligatures:none">Independently decides when additional analyses are needed, arranges for the needed analyses and interprets the resulting design and implements customized protocols.<o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="color:#666666;margin-left:0in;mso-add-space:auto;line-height:18.0pt;mso-list:l2 level1 lfo2;background:white;vertical-align:baseline">
<span style="mso-ligatures:none">Authorizes and organizes the use of laboratory and equipment to ensure timely completion of research projects.<o:p></o:p></span></li><li class="MsoListParagraphCxSpLast" style="color:#666666;margin-left:0in;mso-add-space:auto;line-height:18.0pt;mso-list:l2 level1 lfo2;background:white;vertical-align:baseline">
<span style="mso-ligatures:none">May perform other duties as assigned.<o:p></o:p></span></li></ol>
<p class="MsoNormal" style="margin-left:47.25pt;line-height:18.0pt;background:white;vertical-align:baseline">
<span style="font-size:10.5pt;font-family:"inherit",serif;color:#666666;mso-ligatures:none"><o:p> </o:p></span></p>
<p class="MsoNormal" style="margin-bottom:6.0pt"><b><span style="font-size:14.0pt">Required Education and Experience<o:p></o:p></span></b></p>
<p class="MsoNormal" style="background:white;vertical-align:baseline"><span style="color:#666666;mso-ligatures:none">Master’s Degree in chemistry, biology, biochemistry, or other related discipline and five years of experience or an equivalent combination of
experience and education.<o:p></o:p></span></p>
<p class="MsoNormal" style="background:white;vertical-align:baseline"><span style="color:#666666;mso-ligatures:none"><o:p> </o:p></span></p>
<p class="MsoNormal" style="margin-bottom:6.0pt"><b><span style="font-size:14.0pt">Required Skill/Abilities:<o:p></o:p></span></b></p>
<ol style="margin-top:0in" start="1" type="1">
<li class="MsoListParagraphCxSpFirst" style="color:#666666;margin-left:0in;mso-add-space:auto;line-height:18.0pt;mso-list:l1 level1 lfo3;background:white;vertical-align:baseline">
<span style="mso-ligatures:none">Proven ability to develop new EM sample preparation protocols and to automate EM sample preparation pipeline to support the advances in volume electron microscopy.<o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="color:#666666;margin-left:0in;mso-add-space:auto;line-height:18.0pt;mso-list:l1 level1 lfo3;background:white;vertical-align:baseline">
<span style="mso-ligatures:none">Proven ability to operate instrument and modify its design for improved performance and troubleshoot associated issues.<o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="color:#666666;margin-left:0in;mso-add-space:auto;line-height:18.0pt;mso-list:l1 level1 lfo3;background:white;vertical-align:baseline">
<span style="mso-ligatures:none">Proven ability to search and interpret scientific papers, protocols, standard operating procedures, safety standards, maintenance instructions and procedure manuals for laboratory equipment.<o:p></o:p></span></li><li class="MsoListParagraphCxSpMiddle" style="color:#666666;margin-left:0in;mso-add-space:auto;line-height:18.0pt;mso-list:l1 level1 lfo3;background:white;vertical-align:baseline">
<span style="mso-ligatures:none">Demonstrated capability to manage laboratory facilities and workspaces. Proven ability to plan project needs to optimize resources necessary for successful project completion.<o:p></o:p></span></li><li class="MsoListParagraphCxSpLast" style="color:#666666;margin-left:0in;mso-add-space:auto;line-height:18.0pt;mso-list:l1 level1 lfo3;background:white;vertical-align:baseline">
<span style="mso-ligatures:none">Proven ability to participate in writing of grant proposals and manuscripts.<o:p></o:p></span></li></ol>
<p class="MsoNormal" style="background:white;vertical-align:baseline"><b><span style="font-size:14.0pt;color:#333333;border:none windowtext 1.0pt;padding:0in;mso-ligatures:none"><o:p> </o:p></span></b></p>
<p class="MsoNormal" style="margin-bottom:6.0pt"><b><span style="font-size:14.0pt">Preferred Education, Experience and Skills:<o:p></o:p></span></b></p>
<p class="MsoNormal" style="margin-bottom:11.25pt;background:white;vertical-align:baseline">
<span style="color:#666666;mso-ligatures:none">Ph.D. degree in biology, chemistry, engineering, or other related disciplines plus seven or more years of relevant experience. Special considerations will be given to candidates who have strong background in EM
sample preparation and EM protocol development and have strong interest in automation.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt"><o:p> </o:p></span></p>
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