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<p class="MsoNormal">Dear all,<o:p></o:p></p>
<p class="MsoNormal">Just a reminder the deadline is approaching (<strong><span style="font-family:"Calibri",sans-serif">12th November 2023)</span></strong> for the PDRA position.<o:p></o:p></p>
<p class="MsoNormal">Best,<o:p></o:p></p>
<p class="MsoNormal">Peijun<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<div>
<div style="border:none;border-top:solid #E1E1E1 1.0pt;padding:3.0pt 0cm 0cm 0cm">
<p class="MsoNormal"><b><span lang="EN-US" style="mso-ligatures:none">From:</span></b><span lang="EN-US" style="mso-ligatures:none"> Peijun Zhang
<br>
<b>Sent:</b> Tuesday, October 24, 2023 5:57 PM<br>
<b>To:</b> CCPEM@JISCMAIL.AC.UK; 3dem@ncmir.ucsd.edu<br>
<b>Subject:</b> postdoc position available in Peijun Zhang's group at eBIC, UK<o:p></o:p></span></p>
</div>
</div>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoPlainText"><a name="_Hlk526810490"><b>Postdoctoral Research Associate in eBIC –
<span style="letter-spacing:-.1pt">Androgen receptor with novel antagonists</span><o:p></o:p></b></a></p>
<p class="TextBody" style="margin-bottom:0cm"><span style="mso-bookmark:_Hlk526810490"><b><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#00000A">Harwell, Oxfordshire<o:p></o:p></span></b></span></p>
<p class="MsoBodyText" style="margin-bottom:0cm"><span style="mso-bookmark:_Hlk526810490"><b><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:windowtext">Salary
</span></b></span><span style="mso-bookmark:_Hlk526810490"><b><span style="font-size:11.0pt;font-family:"Calibri",sans-serif">£37,087 to £40,754 per annum (Discretionary range to £46,868).<o:p></o:p></span></b></span></p>
<p class="MsoBodyText" style="margin-bottom:0cm"><span style="mso-bookmark:_Hlk526810490"><b><span style="font-family:"Calibri",sans-serif">Full time, fixed 1 year for the first instance (potentially to 3 years).</span><o:p></o:p></b></span></p>
<p class="MsoPlainText"><span style="mso-bookmark:_Hlk526810490"><b><o:p> </o:p></b></span></p>
<p class="MsoPlainText"><span style="mso-bookmark:_Hlk526810490"></span><a href="https://urldefense.com/v3/__https://vacancies.diamond.ac.uk/vacancy/postdoctoral-research-associate-androgen-receptor-with-novel-antagonists-540865.html__;!!Mih3wA!BmhzwU2Z5Jd2kURBH6F4pGtW7fMk6ZcIni5MvS-2BnWxLbfLbSJI86eGr3vGXwlFa7TMJCH8vQK5Nl6pPhN_Y7YH4PAbCrA5$"><span style="mso-bookmark:_Hlk526810490"><b>https://vacancies.diamond.ac.uk/vacancy/postdoctoral-research-associate-androgen-receptor-with-novel-antagonists-540865.html</b></span><span style="mso-bookmark:_Hlk526810490"></span></a><span style="mso-bookmark:_Hlk526810490"><b><o:p></o:p></b></span></p>
<p class="MsoPlainText"><span style="mso-bookmark:_Hlk526810490"><b><o:p> </o:p></b></span></p>
<p class="MsoPlainText"><span style="mso-bookmark:_Hlk526810490"><b><o:p> </o:p></b></span></p>
<p class="MsoPlainText"><span style="mso-bookmark:_Hlk526810490">A postdoc position is available in Professor Zhang’s lab at the Electron Bio-Imaging Centre (eBIC), Diamond Light Source, UK. The post is funded by an NIH R21 award on “Structural and functional
analysis of a novel class of androgen receptor antagonists”.<o:p></o:p></span></p>
<p class="MsoPlainText"><span style="mso-bookmark:_Hlk526810490"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="mso-bookmark:_Hlk526810490"><span style="color:black">Castration-resistant prostate cancer (CRPC) is currently incurable and is the second leading cause of cancer death in American men. Androgen-independent activation of the
androgen receptor (AR) remains the major driving force leading to CRPC. Structural and functional analysis of a novel class of AR antagonists capable of inducing AR degradation in the nucleus may lead to new therapeutics for CRPC.
<span style="background:white">The posts will take part in the collaborative team research to understand the underlying molecular mechanisms of the inhibition and degradation of nuclear AR by this class of antagonists using structural biology approaches.</span><o:p></o:p></span></span></p>
<p class="MsoPlainText"><span style="mso-bookmark:_Hlk526810490">We are seeking highly motivated scientist to conduct high-resolution structural analysis
<span style="color:black;background:white">of AR in complexes with its</span></span><span style="mso-bookmark:_Hlk526810490"><span style="mso-fareast-language:EN-GB"> antagonists.</span> The post is based in eBIC, the UK national cryoEM facility, which provides
scientists with state-of-the-art instruments and expertise in cryoEM. Currently eBIC houses four Titan Krios, a Talos Arctica, and a Glacios, two cryoFIB/SEM instruments (Scios and Aquilos), and a Leica cryoCLEM for correlative light and electron microscopy
(</span><a href="https://urldefense.com/v3/__https://www.diamond.ac.uk/Instruments/Biological-Cryo-Imaging/eBIC.html__;!!Mih3wA!BmhzwU2Z5Jd2kURBH6F4pGtW7fMk6ZcIni5MvS-2BnWxLbfLbSJI86eGr3vGXwlFa7TMJCH8vQK5Nl6pPhN_Y7YH4JYQEyGd$"><span style="mso-bookmark:_Hlk526810490">https://www.diamond.ac.uk/Instruments/Biological-Cryo-Imaging/eBIC.html</span><span style="mso-bookmark:_Hlk526810490"></span></a><span style="mso-bookmark:_Hlk526810490">).
<o:p></o:p></span></p>
<p class="MsoPlainText"><span style="mso-bookmark:_Hlk526810490"><o:p> </o:p></span></p>
<p class="MsoPlainText"><span style="mso-bookmark:_Hlk526810490">You should have a PhD degree in structural biology or equivalent and have a demonstrated record of accomplishment in conducting high quality original research. Knowledge and research experience
in structural biology, including protein biochemistry and single particle cryoEM, are essential.<o:p></o:p></span></p>
<p class="MsoPlainText"><span style="mso-bookmark:_Hlk526810490"><o:p> </o:p></span></p>
<p class="MsoPlainText"><span style="mso-bookmark:_Hlk526810490"><span lang="EN">Applicants are required to outline their suitability for this role via the online application process and
</span>should include a CV, summary of their accomplishment and research interests, and publication list</span><span style="mso-bookmark:_Hlk526810490"><span lang="EN">.
<o:p></o:p></span></span></p>
<p class="MsoPlainText"><span style="mso-bookmark:_Hlk526810490"><strong><span style="font-family:"Calibri",sans-serif">The initial closing date for applications is 12th November 2023, however applications will be reviewed and interviewed on an ongoing basis
until this vacancy is filled.</span></strong></span><span style="mso-bookmark:_Hlk526810490"><span lang="EN"><o:p></o:p></span></span></p>
<p class="MsoPlainText"><span style="mso-bookmark:_Hlk526810490"><span lang="EN"><o:p> </o:p></span></span></p>
<p class="MsoPlainText"><span style="mso-bookmark:_Hlk526810490">For further information about this role please contact Peijun Zhang (</span><a href="mailto:peijun.zhang@diamond.ac.uk"><span style="mso-bookmark:_Hlk526810490">peijun.zhang@diamond.ac.uk</span><span style="mso-bookmark:_Hlk526810490"></span></a><span style="mso-bookmark:_Hlk526810490">).<o:p></o:p></span></p>
<p class="MsoPlainText"><span style="mso-bookmark:_Hlk526810490"><span lang="EN"><o:p> </o:p></span></span></p>
<p class="MsoPlainText"><span style="mso-bookmark:_Hlk526810490"><a name="_Hlk39506144"><span lang="EN">Other information
<o:p></o:p></span></a></span></p>
<p class="MsoPlainText"><span style="mso-bookmark:_Hlk526810490"><span style="mso-bookmark:_Hlk39506144"><span lang="EN">Diamond offers an exceptional benefits package to ensure an excellent work/life balance including 25 days’ annual leave, 13 days statutory
and company holidays, flexible working hours, an onsite nursery, an excellent pension scheme, and social and sporting activities.<o:p></o:p></span></span></span></p>
<ul type="disc">
<li class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l1 level1 lfo3">
<span style="mso-bookmark:_Hlk526810490"><span style="mso-bookmark:_Hlk39506144"></span></span><a href="https://urldefense.com/v3/__http://www.diamond.ac.uk/Careers/Company-Benefits.html__;!!Mih3wA!BmhzwU2Z5Jd2kURBH6F4pGtW7fMk6ZcIni5MvS-2BnWxLbfLbSJI86eGr3vGXwlFa7TMJCH8vQK5Nl6pPhN_Y7YH4PFDWPWU$"><span style="mso-bookmark:_Hlk526810490"><span style="mso-bookmark:_Hlk39506144">Company benefits</span></span><span style="mso-bookmark:_Hlk526810490"><span style="mso-bookmark:_Hlk39506144"></span></span></a><span style="mso-bookmark:_Hlk526810490"><span style="mso-bookmark:_Hlk39506144"><o:p></o:p></span></span></li><li class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l1 level1 lfo3">
<span style="mso-bookmark:_Hlk526810490"><span style="mso-bookmark:_Hlk39506144"></span></span><a href="https://urldefense.com/v3/__http://www.diamond.ac.uk/Careers/Applicant-Information/LocalArea.html__;!!Mih3wA!BmhzwU2Z5Jd2kURBH6F4pGtW7fMk6ZcIni5MvS-2BnWxLbfLbSJI86eGr3vGXwlFa7TMJCH8vQK5Nl6pPhN_Y7YH4H6h7dT0$"><span style="mso-bookmark:_Hlk526810490"><span style="mso-bookmark:_Hlk39506144">Life
at diamond</span></span><span style="mso-bookmark:_Hlk526810490"><span style="mso-bookmark:_Hlk39506144"></span></span></a><span style="mso-bookmark:_Hlk39506144"></span><span style="mso-bookmark:_Hlk526810490"><o:p></o:p></span></li></ul>
<p class="MsoNormal"><span style="mso-bookmark:_Hlk526810490"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="mso-bookmark:_Hlk526810490"><o:p> </o:p></span></p>
<p class="MsoNormal" style="margin-bottom:.5pt;background:white"><span style="mso-bookmark:_Hlk526810490"><b><span style="color:black;background:white;mso-ligatures:none;mso-fareast-language:EN-GB">Peijun Zhang<o:p></o:p></span></b></span></p>
<p class="MsoNormal" style="margin-bottom:.5pt"><span style="mso-bookmark:_Hlk526810490"><span style="font-size:10.0pt;mso-ligatures:none">Professor<o:p></o:p></span></span></p>
<p class="MsoNormal" style="margin-bottom:.5pt"><span style="mso-bookmark:_Hlk526810490"><span style="font-size:10.0pt;mso-ligatures:none">Division of Structural Biology<o:p></o:p></span></span></p>
<p class="MsoNormal" style="margin-bottom:.5pt"><span style="mso-bookmark:_Hlk526810490"><span style="font-size:10.0pt;mso-ligatures:none">Wellcome Trust Centre for Human Genetics<o:p></o:p></span></span></p>
<p class="MsoNormal" style="margin-bottom:.5pt"><span style="mso-bookmark:_Hlk526810490"><span style="font-size:10.0pt;mso-ligatures:none">University of Oxford<o:p></o:p></span></span></p>
<p class="MsoNormal" style="margin-bottom:.5pt"><span style="mso-bookmark:_Hlk526810490"><span style="font-size:10.0pt;mso-ligatures:none">Roosevelt Drive Oxford OX3 7BN, UK<o:p></o:p></span></span></p>
<p class="MsoNormal" style="margin-bottom:.5pt"><span style="mso-bookmark:_Hlk526810490"></span><a href="mailto:Peijun.zhang@strubi.ox.ac.uk"><span style="mso-bookmark:_Hlk526810490"><span style="font-size:10.0pt;color:blue;mso-ligatures:none">Peijun.zhang@strubi.ox.ac.uk</span></span><span style="mso-bookmark:_Hlk526810490"></span></a><span style="mso-bookmark:_Hlk526810490"><span style="font-size:10.0pt;mso-ligatures:none"><o:p></o:p></span></span></p>
<p class="MsoNormal" style="margin-bottom:.5pt"><span style="mso-bookmark:_Hlk526810490"></span><a href="https://urldefense.com/v3/__https://www.ndm.ox.ac.uk/team/peijun-zhang/view__;!!Mih3wA!BmhzwU2Z5Jd2kURBH6F4pGtW7fMk6ZcIni5MvS-2BnWxLbfLbSJI86eGr3vGXwlFa7TMJCH8vQK5Nl6pPhN_Y7YH4JCpvIXK$"><span style="mso-bookmark:_Hlk526810490"><span style="font-size:10.0pt;color:blue;mso-ligatures:none">https://www.ndm.ox.ac.uk/team/peijun-zhang/view</span></span><span style="mso-bookmark:_Hlk526810490"></span></a><span style="mso-bookmark:_Hlk526810490"><span lang="EN-US" style="font-size:10.0pt;mso-ligatures:none"><o:p></o:p></span></span></p>
<p class="MsoNormal" style="margin-bottom:.5pt"><span style="mso-bookmark:_Hlk526810490"><span style="font-size:10.0pt;mso-ligatures:none"><o:p> </o:p></span></span></p>
<p class="MsoNormal" style="margin-bottom:.5pt"><span style="mso-bookmark:_Hlk526810490"><span style="font-size:10.0pt;mso-ligatures:none">Director<o:p></o:p></span></span></p>
<p class="MsoNormal" style="margin-bottom:.5pt"><span style="mso-bookmark:_Hlk526810490"><span style="font-size:10.0pt;mso-ligatures:none">Electron Bio-Imaging Centre<o:p></o:p></span></span></p>
<p class="MsoNormal" style="margin-bottom:.5pt"><span style="mso-bookmark:_Hlk526810490"><span style="font-size:10.0pt;mso-ligatures:none">Diamond Light Source<o:p></o:p></span></span></p>
<span style="mso-bookmark:_Hlk526810490"></span>
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