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<!--StartFragment--><p class="MsoNormal" style="margin-bottom:3.0pt;line-height:normal"><strong class=""><span style="font-size:14.0pt;font-family:"Arial",sans-serif;color:#333333;
background:white" class="">Joint Postdoctoral position @ Cheng & Zhou lab- <span style="background:yellow;mso-highlight:yellow" class="">Structural biology of Aging</span><o:p class=""></o:p></span></strong></p><p class="MsoNormal" style="margin-bottom:3.0pt;text-align:justify;text-justify:
inter-ideograph;line-height:normal"><span style="font-size:12.0pt;font-family:
"Arial",sans-serif;color:#333333;background:white" class="">The </span><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:#333333;
background:white;mso-fareast-language:ZH-CN" class="">Yifan Cheng lab @UCSF&HHMI and
</span><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:#333333;
background:white" class="">Chuankai (Kai) Zhou lab @ Buck Institute (Bay Area of
California) </span><span style="font-size:12.0pt;font-family:"Arial",sans-serif;
color:#333333;background:white;mso-fareast-language:ZH-CN" class="">would like to
jointly hire </span><span style="font-size:12.0pt;font-family:"Arial",sans-serif;
color:#333333;background:white" class="">1-2 <strong class="">Postdoctoral
Researcher</strong> to study the biophysics & biochemistry of proteostasis
and protein folding under stress and aging using Cryo-EM & molecular
dynamics (MD) simulation. The postdoc candidate will work in both labs to
combine the strengths and technologies to investigate the proteostasis and
protein folding changes during aging and stress using budding yeast, human cell
culture, and senescent cells as the model (fruit fly is another model we have
in lab). </span><span style="font-size:12.0pt;font-family:"Arial",sans-serif;
color:#333333;background:white;mso-fareast-language:ZH-CN" class=""><o:p class=""></o:p></span></p><p class="MsoNormal" style="margin-top:6.0pt;margin-right:0in;margin-bottom:3.0pt;
margin-left:0in;text-align:justify;text-justify:inter-ideograph;line-height:
normal"><span style="font-size:12.0pt;font-family:"Arial",sans-serif;
color:#333333;background:white" class="">Proteostasis defect is a conserved hallmark of
aging and many neurodegenerative diseases, including AD. In fact, many of these
age-associated neurodegenerative diseases are protein folding diseases induced
by aging (e.g., amyloid transition from native proteins). To systematically
understand how the cellular proteome (e.g., protein folding and misfolding)
responds to aging/senescence and age-related diseases, we leverage an array of
cutting-edge techniques, including super resolution imaging, high-throughput
screening, biochemistry & cryo-EM, bioinformatics, MD simulation, and
machine learning from two labs to investigate the problem in both systematic
and atomic level. For this joint postdoc position, we are interested in
questions related to <b class="">protein folding plasticity induced by aging and stress</b>.<o:p class=""></o:p></span></p><p class="MsoNormal" style="margin-top:12.0pt;margin-right:0in;margin-bottom:
0in;margin-left:0in;line-height:normal"><strong class=""><span style="font-size:12.0pt;
font-family:"Arial",sans-serif;color:#333333;background:white" class="">QUALIFICATIONS</span></strong><strong class=""><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:#333333;
background:white;font-weight:normal" class=""><o:p class=""></o:p></span></strong></p><p class="MsoListParagraphCxSpFirst" style="margin-bottom:0in;mso-add-space:auto;
text-indent:-.25in;line-height:normal;mso-list:l0 level1 lfo1"><span style="font-size:12.0pt;font-family:Symbol;mso-fareast-font-family:Symbol;
mso-bidi-font-family:Symbol;color:#333333" class=""><span style="mso-list:Ignore" class=""><span style="font:7.0pt "Times New Roman"" class=""> <span class="Apple-tab-span" style="white-space:pre"> </span></span></span></span><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:#333333;
background:white" class="">1>With background on biochemistry & cryo-EM and/or MD
simulation. We also welcome people with degrees in biology, chemistry, computer
science, or related and are interested in learning structural biology.<o:p class=""></o:p></span></p><p class="MsoListParagraphCxSpLast" style="margin-bottom:0in;mso-add-space:auto;
text-indent:-.25in;line-height:normal;mso-list:l0 level1 lfo1"><span style="font-size:12.0pt;font-family:Symbol;mso-fareast-font-family:Symbol;
mso-bidi-font-family:Symbol;color:#333333" class=""><span style="mso-list:Ignore" class=""><span style="font:7.0pt "Times New Roman"" class=""><span class="Apple-tab-span" style="white-space:pre"> </span> <span class="Apple-tab-span" style="white-space:pre"> </span></span></span></span><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:#333333;
background:white" class="">2>Strong interest in proteostasis (including protein folding)
and aging. <o:p class=""></o:p></span></p><p class="MsoNormal" style="margin-top:12.0pt;margin-right:0in;margin-bottom:
0in;margin-left:0in;line-height:normal"><strong style="text-align: justify;" class=""><span style="font-size:12.0pt;font-family:"Arial",sans-serif;
color:#333333;background:white" class="">TO APPLY</span></strong></p>
<span style="font-size:12.0pt;line-height:107%;font-family:"Arial",sans-serif;
mso-fareast-font-family:SimSun;color:#333333;background:white;mso-ansi-language:
EN-US;mso-fareast-language:EN-US;mso-bidi-language:AR-SA" class="">Please submit a cover
letter addressing your past research experience, plans, and expectations for
working in both labs. Please also include a current CV and three professional
references. Please feel free to consult Dr. Cheng or Dr. Zhou via email (</span><span style="font-size:11.0pt;line-height:107%;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-fareast-font-family:SimSun;mso-hansi-theme-font:
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mso-ansi-language:EN-US;mso-fareast-language:EN-US;mso-bidi-language:AR-SA" class=""><a href="mailto:Yifan.Cheng@ucsf.edu" class=""><span style="font-size:12.0pt;line-height:
107%;font-family:"Arial",sans-serif;background:white" class="">Yifan.Cheng@ucsf.edu</span></a></span><span style="font-size:12.0pt;line-height:107%;font-family:"Arial",sans-serif;
mso-fareast-font-family:SimSun;color:#333333;background:white;mso-ansi-language:
EN-US;mso-fareast-language:EN-US;mso-bidi-language:AR-SA" class="">; </span><span style="font-size:11.0pt;line-height:107%;font-family:"Calibri",sans-serif;
mso-ascii-theme-font:minor-latin;mso-fareast-font-family:SimSun;mso-hansi-theme-font:
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107%;font-family:"Arial",sans-serif;background:white" class="">kzhou@buckinstitute.org</span></a></span><span style="font-size:12.0pt;line-height:107%;font-family:"Arial",sans-serif;
mso-fareast-font-family:SimSun;color:#333333;background:white;mso-ansi-language:
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<w:LsdException Locked="false" Priority="39" SemiHidden="true"
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<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
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<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
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<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
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<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
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<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
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<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
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<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
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<w:LsdException Locked="false" SemiHidden="true" UnhideWhenUsed="true"
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<w:LsdException Locked="false" Priority="33" QFormat="true" Name="Book Title"/>
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<w:LsdException Locked="false" Priority="39" SemiHidden="true"
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<w:LsdException Locked="false" Priority="48" Name="Grid Table 3"/>
<w:LsdException Locked="false" Priority="49" Name="Grid Table 4"/>
<w:LsdException Locked="false" Priority="50" Name="Grid Table 5 Dark"/>
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<w:LsdException Locked="false" Priority="52" Name="Grid Table 7 Colorful"/>
<w:LsdException Locked="false" Priority="46"
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<w:LsdException Locked="false" Priority="49" Name="Grid Table 4 Accent 1"/>
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<w:LsdException Locked="false" Priority="52"
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<w:LsdException Locked="false" Priority="46"
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<w:LsdException Locked="false" Priority="49" Name="Grid Table 4 Accent 2"/>
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<w:LsdException Locked="false" Priority="51"
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<w:LsdException Locked="false" Priority="52"
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<w:LsdException Locked="false" Priority="46"
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<w:LsdException Locked="false" Priority="48" Name="Grid Table 3 Accent 3"/>
<w:LsdException Locked="false" Priority="49" Name="Grid Table 4 Accent 3"/>
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<w:LsdException Locked="false" Priority="51"
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<w:LsdException Locked="false" Priority="52"
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<w:LsdException Locked="false" Priority="46"
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12.0pt;font-family:"Arial",sans-serif;mso-fareast-font-family:Arial" class="">2)<span style="font-stretch: normal; font-size: 7pt; line-height: normal; font-family: "Times New Roman";" class="">
</span></span><!--[endif]--><span style="font-size:12.0pt;font-family:"Arial",sans-serif" class="">Wu
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12.0pt;font-family:"Arial",sans-serif;mso-fareast-font-family:Arial" class="">3)<span style="font-stretch: normal; font-size: 7pt; line-height: normal; font-family: "Times New Roman";" class="">
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<!--StartFragment--><!--EndFragment--><div class=""><span style="font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); float: none; display: inline !important;" class="">Kai Zhou, Ph.D.</span><br style="font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0);" class=""><span style="font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); float: none; display: inline !important;" class="">Assistant Professor</span><br style="font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0);" class=""><br style="font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0);" class=""><span style="font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); float: none; display: inline !important;" class="">The Buck Institute</span><br style="font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0);" class=""><span style="font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); float: none; display: inline !important;" class="">8001 Redwood Blvd</span><br style="font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0);" class=""><span style="font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); float: none; display: inline !important;" class="">Novato, CA 94945</span><br style="font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0);" class=""><span style="font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); float: none; display: inline !important;" class="">office #: 415-209-2037</span><br style="font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0);" class=""><span style="font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); float: none; display: inline !important;" class="">office: 3-237</span><div style="font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0);" class="">Admin assistant: Irene Emma (<a href="mailto:IEmma@buckinstitute.org" class="">IEmma@buckinstitute.org</a>)<br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none;" class=""><span style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none; float: none; display: inline !important;" class=""><a href="https://www.buckinstitute.org/lab/zhou-lab/" class="">https://www.buckinstitute.org/lab/zhou-lab/</a></span><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none;" class=""><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none;" class=""><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none;" class=""><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none;" class=""><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none;" class=""></div>
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