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<p class="MsoNormal">Dear colleagues,<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">Related to the cryo-EM workstation suggestion.<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">Regarding the Cryo-EM workstation suggestion, I'm looking for insights from anyone who has experience comparing a setup with 2x 4090 GPUs to one with 4xA4500 GPUs, while keeping all other configurations identical, such as a 32-core CPU
and 512GB of RAM. Both options fall within the same price range. I understand that the performance of the 4090 GPUs is significantly better than the A4500 GPUs. However, I'm concerned about the trade-off between having two jobs running concurrently with the
2x 4090 setup versus having the ability to run four jobs simultaneously with the 4xA4500 setup in applications like CryoSPARC.<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">I would greatly appreciate hearing from anyone who has practical experience with these configurations and any suggestions you might have.
<o:p></o:p></p>
<p class="MsoNormal">Thank you in advance for your insights.<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">Tinghai<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">-----------------------<o:p></o:p></p>
<p class="MsoNormal">Tinghai Xu, Ph.D. <o:p></o:p></p>
<p class="MsoNormal">Assistant Professor<o:p></o:p></p>
<p class="MsoNormal">Edward A. Doisy Research Center, Room 553<o:p></o:p></p>
<p class="MsoNormal">Department of Biochemistry and Molecular Biology<o:p></o:p></p>
<p class="MsoNormal">Saint Louis University School of Medicine<o:p></o:p></p>
<p class="MsoNormal">1100 South Grand Blvd.<o:p></o:p></p>
<p class="MsoNormal">St. Louis, MO 63104<o:p></o:p></p>
<p class="MsoNormal">Email: <a href="mailto:TinghaiXu@gmail.com">TinghaiXu@gmail.com</a><o:p></o:p></p>
<p class="MsoNormal">Homepage: <a href="https://urldefense.com/v3/__http://www.xulaboratory.org__;!!Mih3wA!CWyA7lLaApiEKRIKb3KL7qFncAZElQlB3PbItpR_LqNoelmpusa4xn0FG3GM2forneAXQkP7cGCd8fk1Tk5q$">www.xulaboratory.org</a><o:p></o:p></p>
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<p class="MsoNormal"><b>From:</b> 3dem <3dem-bounces@ncmir.ucsd.edu> <b>On Behalf Of
</b>Guillaume Gaullier<br>
<b>Sent:</b> Wednesday, October 4, 2023 3:44 PM<br>
<b>To:</b> Yingxia Hu <yhu@hexagonbio.com><br>
<b>Cc:</b> 3dem@ncmir.ucsd.edu<br>
<b>Subject:</b> [External] Re: [3dem] Seeking advice for RELION cryo-EM workstation<o:p></o:p></p>
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<p class="MsoNormal">Hi Alicia, <o:p></o:p></p>
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<p class="MsoNormal">60 TB of bulk storage (maybe less usable space, depending on the raid configuration of these HDD) will be barely sufficient for working on one dataset at a time. Storage is the most overlooked of the configuration options (we are all obsessed
with computing power, GPUs, etc.), but insufficient storage will be an endless source of problems and frustration down the road (speaking from experience…). You will be wasting GPU time if a significant fraction of the time is spent moving data around because
the workstation’s bulk storage is full.<o:p></o:p></p>
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<p class="MsoNormal"><o:p> </o:p></p>
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<p class="MsoNormal">So you should plan for this before buying, and m<span style="color:black">y main recommendation is to get as much bulk storage as you can afford.</span><o:p></o:p></p>
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<p class="MsoNormal">I hope this helps,<o:p></o:p></p>
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<p class="MsoNormal"><span style="font-size:9.0pt;font-family:"Helvetica",sans-serif;color:black"><br>
Guillaume<o:p></o:p></span></p>
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<p class="MsoNormal">On 3 Oct 2023, at 23:18, Yingxia Hu <<a href="mailto:yhu@hexagonbio.com">yhu@hexagonbio.com</a>> wrote:<o:p></o:p></p>
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<p class="MsoNormal"><o:p> </o:p></p>
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<p class="MsoNormal">Dear colleagues, <o:p></o:p></p>
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<p class="MsoNormal">I am seeking advice on building a cryo-EM workstation for data processing using RELION. Here is a draft configuration: <o:p></o:p></p>
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1x Intel Xeon W Series CPU, 12 cores, 3.20 GHz; <o:p></o:p></li><li class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l0 level1 lfo1">
8x32GB RAM;<o:p></o:p></li><li class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l0 level1 lfo1">
1TB M2 drive for OS, 3.84TB U.2 NVMe drive for scratch disk;<o:p></o:p></li><li class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l0 level1 lfo1">
3x20TB <span style="font-family:"Arial",sans-serif">Hard Drive (3.5" Internal - SATA/600 - 7200rpm);</span><o:p></o:p></li><li class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l0 level1 lfo1">
2x Nvidia RTX A4500. <o:p></o:p></li></ul>
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<p class="MsoNormal">Would 2x A4500 be sufficient for RELION jobs? And which one would be better between 4070 (12GB memory, faster clock speed) and A4500 (20GB, slower clock speed)? Any other advice is appreciated. Thanks in advance!<o:p></o:p></p>
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<p class="MsoNormal">Best,<o:p></o:p></p>
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<p class="MsoNormal">Alicia<o:p></o:p></p>
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<p class="MsoNormal" style="line-height:12.0pt;background:white"><span style="font-size:10.0pt;color:black">VARNING: Klicka inte på länkar och öppna inte bilagor om du inte känner igen avsändaren och vet att innehållet är säkert.<br>
CAUTION: Do not click on links or open attachments unless you recognise the sender and know the content is safe.</span><span style="font-size:10.0pt"><o:p></o:p></span></p>
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<p class="MsoNormal">_______________________________________________<br>
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