<div dir="ltr"><p dir="ltr" style="line-height:1.2;text-align:justify;margin-top:0pt;margin-bottom:0pt"><span style="font-size:10.5pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline;white-space:pre-wrap">Dear 3DEM Community,</span></p><br><p dir="ltr" style="line-height:1.2;text-align:justify;margin-top:0pt;margin-bottom:0pt"><span style="font-size:10.5pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline;white-space:pre-wrap">Our lab at Stanford (</span><a href="https://urldefense.com/v3/__https://rogala.stanford.edu/__;!!Mih3wA!BUpqoKu5Q8PldhNDtEgPa5VBKHwCTA930RPSiaKJ1YYbLXYEdPu6tcGRlberV7NG8HTz6yHadxjGVsQfe_JGIg$" target="_blank" style="text-decoration-line:none"><span style="font-size:10.5pt;font-family:Arial;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;text-decoration-line:underline;vertical-align:baseline;white-space:pre-wrap">https://rogala.stanford.edu</span></a><span style="font-size:10.5pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline;white-space:pre-wrap">) has open postdoctoral positions for structural biologists and protein biochemists. We are a fairly young lab, and we are looking for driven candidates with a start-up mentality and a deep interest in deciphering protein mechanisms. Please feel free to spread the word to your about-to-graduate PhD students who might be looking for their next career step!</span></p><br><p dir="ltr" style="line-height:1.2;text-align:justify;margin-top:0pt;margin-bottom:0pt"><span style="font-size:10.5pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline;white-space:pre-wrap">Please see the official ad on the Stanford postdoc website </span><a href="https://urldefense.com/v3/__https://postdocs.stanford.edu/prospective/opportunities/open-postdoctoral-position-faculty-mentor-kacper-rogala__;!!Mih3wA!BUpqoKu5Q8PldhNDtEgPa5VBKHwCTA930RPSiaKJ1YYbLXYEdPu6tcGRlberV7NG8HTz6yHadxjGVsTk2FT6og$" target="_blank" style="text-decoration-line:none"><span style="font-size:10.5pt;font-family:Arial;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;text-decoration-line:underline;vertical-align:baseline;white-space:pre-wrap">here</span></a><span style="font-size:10.5pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline;white-space:pre-wrap">, and a short blurb below — describing what the lab is about.</span></p><br><p dir="ltr" style="line-height:1.2;text-align:justify;margin-top:0pt;margin-bottom:0pt"><span style="font-size:10.5pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline;white-space:pre-wrap">Potential candidates, please write a few lines about yourself — about your previous research experience, and what you liked about our lab that got you interested! Please include your CV and contact details to three references.</span></p><br><p dir="ltr" style="line-height:1.2;text-align:justify;margin-top:0pt;margin-bottom:0pt"><span style="font-size:10.5pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline;white-space:pre-wrap">Many thanks and best wishes,</span></p><br><p dir="ltr" style="line-height:1.2;text-align:justify;margin-top:0pt;margin-bottom:0pt"><span style="font-size:10.5pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline;white-space:pre-wrap">Kacper

<div><span style="color:rgb(148,17,0);font-family:Georgia,serif,serif,EmojiFont;font-size:9pt">KACPER ROGALA, D.PHIL. </div><div><p style="margin:0px;color:rgb(33,33,33);font-size:11pt;font-family:Calibri,sans-serif,serif,EmojiFont"><span style="color:black"><font color="#5e5e5e" face="Georgia, serif, serif, EmojiFont"><span style="font-size:12px">Assistant Professor <p style="margin:0px;color:rgb(33,33,33);font-size:11pt;font-family:Calibri,sans-serif,serif,EmojiFont"><span style="color:rgb(75,172,198)">–––––––––––––––––––––––––––––––-<p style="margin:0px;color:rgb(33,33,33);font-size:11pt;font-family:Calibri,sans-serif,serif,EmojiFont"><a href="https://urldefense.com/v3/__https://med.stanford.edu/structuralbio.html__;!!Mih3wA!BUpqoKu5Q8PldhNDtEgPa5VBKHwCTA930RPSiaKJ1YYbLXYEdPu6tcGRlberV7NG8HTz6yHadxjGVsRB1sGXlA$" rel="noopener noreferrer" target="_blank"><span style="color:rgb(148,17,0);font-size:9pt;font-family:Georgia,serif,serif,EmojiFont">Department of Structural Biology</a><span style="color:black"> <p style="margin:0px;color:rgb(33,33,33);font-size:11pt;font-family:Calibri,sans-serif,serif,EmojiFont"><a href="https://urldefense.com/v3/__https://chemsysbio.stanford.edu/__;!!Mih3wA!BUpqoKu5Q8PldhNDtEgPa5VBKHwCTA930RPSiaKJ1YYbLXYEdPu6tcGRlberV7NG8HTz6yHadxjGVsTk41StZA$" rel="noopener noreferrer" target="_blank"><span style="color:rgb(148,17,0);font-size:9pt;font-family:Georgia,serif,serif,EmojiFont">Department of Chemical and Systems Biology</a> <a href="https://urldefense.com/v3/__http://med.stanford.edu/cancer.html__;!!Mih3wA!BUpqoKu5Q8PldhNDtEgPa5VBKHwCTA930RPSiaKJ1YYbLXYEdPu6tcGRlberV7NG8HTz6yHadxjGVsQNl0tduA$" rel="noopener noreferrer" target="_blank"><span style="color:rgb(148,17,0);font-size:9pt;font-family:Georgia,serif,serif,EmojiFont">Stanford Cancer Institute</a> <p style="margin:0px;color:rgb(33,33,33);font-size:11pt;font-family:Calibri,sans-serif,serif,EmojiFont"><span style="color:rgb(89,89,89);font-family:Georgia,serif,serif,EmojiFont;font-size:12px">Stanford University School of Medicine <p style="margin:0px"><font color="#595959" face="Georgia, serif, serif, EmojiFont"><span style="font-size:12px">Biomedical Innovations Building 240 Pasteur Drive<span style="color:rgb(89,89,89);font-family:Georgia,serif,serif,EmojiFont;font-size:9pt">, 4700 <span style="color:maroon;font-family:Georgia,serif,serif,EmojiFont;font-size:9pt">| <span style="color:rgb(89,89,89);font-family:Georgia,serif,serif,EmojiFont;font-size:9pt">Palo Alto, CA, <font color="#595959" face="Georgia, serif, serif, EmojiFont"><span style="font-size:12px">94304<p style="margin:0px"><a href="https://urldefense.com/v3/__https://rogala.stanford.edu/__;!!Mih3wA!BUpqoKu5Q8PldhNDtEgPa5VBKHwCTA930RPSiaKJ1YYbLXYEdPu6tcGRlberV7NG8HTz6yHadxjGVsQfe_JGIg$" rel="noopener noreferrer" target="_blank" style="font-family:Calibri,sans-serif,serif,EmojiFont;font-size:14.6667px"><span style="color:rgb(148,17,0);font-size:9pt;font-family:Georgia,serif,serif,EmojiFont">https://rogala.stanford.edu</a></div><p dir="ltr" style="line-height:1.2;text-align:justify;margin-top:0pt;margin-bottom:0pt"> <p dir="ltr" style="line-height:1.2;text-align:justify;margin-top:0pt;margin-bottom:0pt"><span style="font-size:10.5pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline;white-space:pre-wrap">We are a team of structural and chemical biologists fascinated by how cells control their metabolism in response to nutrients. How are nutrients recognized by their protein sensors? How is their transport across cellular and intracellular membranes regulated? And, how is nutrient sensing integrated with other chemical signals, such as hormones, to determine cellular decisions, especially the decision: <span style="font-size:10.5pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-weight:700;font-style:italic;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline;white-space:pre-wrap">to grow<span style="font-size:10.5pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline;white-space:pre-wrap"> or <span style="font-size:10.5pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-weight:700;font-style:italic;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline;white-space:pre-wrap">not to grow<span style="font-size:10.5pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline;white-space:pre-wrap">? We are aiming to answer these fundamental questions at the level of ångstroms, nanometers, and micrometers — with cryo-EM, X-ray crystallography, and a full range of other techniques. Many proteins in nutrient signaling pathways are deregulated in cancer, and in parallel to the mechanistic structural work, we are also developing targeted chemical probes to modulate activity of these proteins in cells and organisms. <p dir="ltr" style="line-height:1.2;text-align:justify;margin-top:0pt;margin-bottom:0pt"><span style="font-size:10.5pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline;white-space:pre-wrap">We work on large soluble signaling complexes and membrane protein transporters. <p dir="ltr" style="line-height:1.2;text-align:justify;margin-top:0pt;margin-bottom:0pt"><span style="font-size:10.5pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline;white-space:pre-wrap">Our latest papers on this topic are:<ul style="margin-top:0px;margin-bottom:0px"><li dir="ltr" style="margin-left:15px;list-style-type:disc;font-size:10.5pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline;white-space:pre-wrap"><p dir="ltr" role="presentation" style="line-height:1.2;margin-top:5pt;margin-bottom:0pt"><span style="font-size:10.5pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline">Valenstein and <span style="font-size:10.5pt;background-color:transparent;font-weight:700;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline">Rogala <span style="font-size:10.5pt;background-color:transparent;font-style:italic;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline">et al<span style="font-size:10.5pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline">. (<span style="font-size:10.5pt;background-color:transparent;font-weight:700;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline">2022<span style="font-size:10.5pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline">) Structure of the nutrient-sensing hub GATOR2. <span style="font-size:10.5pt;background-color:transparent;font-weight:700;font-style:italic;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline">Nature<span style="font-size:10.5pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline">, 607(7919):610-616. PMID: <a href="https://urldefense.com/v3/__https://pubmed.ncbi.nlm.nih.gov/35831510/__;!!Mih3wA!BUpqoKu5Q8PldhNDtEgPa5VBKHwCTA930RPSiaKJ1YYbLXYEdPu6tcGRlberV7NG8HTz6yHadxjGVsRdp-wZNw$" target="_blank" style="text-decoration-line:none"><span style="font-size:10.5pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;text-decoration-line:underline;vertical-align:baseline">35831510</a><span style="font-size:10.5pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline">.</li><li dir="ltr" style="margin-left:15px;list-style-type:disc;font-size:10.5pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline;white-space:pre-wrap"><p dir="ltr" role="presentation" style="line-height:1.2;margin-top:5pt;margin-bottom:0pt"><span style="font-size:10.5pt;background-color:transparent;font-weight:700;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline">Rogala <span style="font-size:10.5pt;background-color:transparent;font-style:italic;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline">et al.<span style="font-size:10.5pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline"> (<span style="font-size:10.5pt;background-color:transparent;font-weight:700;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline">2019<span style="font-size:10.5pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline">) Structural basis for the docking of mTORC1 on the lysosomal surface. <span style="font-size:10.5pt;background-color:transparent;font-weight:700;font-style:italic;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline">Science<span style="font-size:10.5pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline">, 366(6464):468-475. PMID: <a href="https://urldefense.com/v3/__https://pubmed.ncbi.nlm.nih.gov/31601708__;!!Mih3wA!BUpqoKu5Q8PldhNDtEgPa5VBKHwCTA930RPSiaKJ1YYbLXYEdPu6tcGRlberV7NG8HTz6yHadxjGVsQTyHofOw$" target="_blank" style="text-decoration-line:none"><span style="font-size:10.5pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;text-decoration-line:underline;vertical-align:baseline">31601708</a><span style="font-size:10.5pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline">.</li><li dir="ltr" style="margin-left:15px;list-style-type:disc;font-size:10.5pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline;white-space:pre-wrap"><p dir="ltr" role="presentation" style="line-height:1.2;margin-top:5pt;margin-bottom:0pt"><span style="font-size:10.5pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline">Shen and <span style="font-size:10.5pt;background-color:transparent;font-weight:700;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline">Rogala <span style="font-size:10.5pt;background-color:transparent;font-style:italic;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline">et al<span style="font-size:10.5pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline">. (<span style="font-size:10.5pt;background-color:transparent;font-weight:700;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline">2019<span style="font-size:10.5pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline">) Cryo-EM structure of the human FLCN-FNIP2-Rag-Ragulator complex. <span style="font-size:10.5pt;background-color:transparent;font-weight:700;font-style:italic;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline">Cell<span style="font-size:10.5pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline">, 179(6):1319-1329.e8. PMID: <a href="https://urldefense.com/v3/__https://pubmed.ncbi.nlm.nih.gov/31704029__;!!Mih3wA!BUpqoKu5Q8PldhNDtEgPa5VBKHwCTA930RPSiaKJ1YYbLXYEdPu6tcGRlberV7NG8HTz6yHadxjGVsTjNbaEyA$" target="_blank" style="text-decoration-line:none"><span style="font-size:10.5pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;text-decoration-line:underline;vertical-align:baseline">31704029</a><span style="font-size:10.5pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;font-variant-alternates:normal;vertical-align:baseline">.

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