<div dir="ltr">Dear 3DEM,<br><br>We are pleased to announce the stable release of CryoSPARC v4, available today as v4.2.1. Thank you to all users and testers during the private and public beta periods.<br><br>Version 4 includes:<br><ul><li>A fully re-designed web application interface to support more complex and performant workflows, including new interactive jobs for curating and inspecting data, a filtering and tagging system for organizing projects and jobs, integrated CryoSPARC Live, integrated 3D volume viewer, and more.</li><li><a href="https://urldefense.com/v3/__https://guide.cryosparc.com/processing-data/tutorials-and-case-studies/tutorial-3d-flexible-refinement__;!!Mih3wA!EOkZuuIALzxAHzrIjYj1ZqrDGOytr9ENngXszTEMGzBRfwTDaFrYWKP3u_YMy5uf0e0lVJ0gYwv1Ar18cb4M471aDxeL$">3DFlex (BETA)</a>, a motion-based deep generative model for continuous heterogeneity that models non-rigid motion and flexibility of a protein molecule.</li><li><a href="https://urldefense.com/v3/__https://tools.cryosparc.com/intro.html__;!!Mih3wA!EOkZuuIALzxAHzrIjYj1ZqrDGOytr9ENngXszTEMGzBRfwTDaFrYWKP3u_YMy5uf0e0lVJ0gYwv1Ar18cb4M4woPiU8v$">cryosparc-tools</a>, an open-source Python library that provides advanced scripting access to CryoSPARC metadata and outputs.</li><li>Major improvements in project and data management systems, cluster integration, report generation, installation tests, and more.</li></ul><br>Please see our v4 application <a href="https://urldefense.com/v3/__https://youtu.be/b9UD7_GGZas__;!!Mih3wA!EOkZuuIALzxAHzrIjYj1ZqrDGOytr9ENngXszTEMGzBRfwTDaFrYWKP3u_YMy5uf0e0lVJ0gYwv1Ar18cb4M45sfDTsv$">walkthrough video</a> and <a href="https://urldefense.com/v3/__https://guide.cryosparc.com/application-guide-v4.0*/a-tour-of-the-cryosparc-interface__;Kw!!Mih3wA!EOkZuuIALzxAHzrIjYj1ZqrDGOytr9ENngXszTEMGzBRfwTDaFrYWKP3u_YMy5uf0e0lVJ0gYwv1Ar18cb4M4_Z41WT_$">comprehensive guide</a>. A detailed changelog is available at <a href="https://urldefense.com/v3/__http://cryosparc.com/updates__;!!Mih3wA!EOkZuuIALzxAHzrIjYj1ZqrDGOytr9ENngXszTEMGzBRfwTDaFrYWKP3u_YMy5uf0e0lVJ0gYwv1Ar18cb4M4-NpadcS$">cryosparc.com/updates</a>.<br><br>Thank you!<br><a href="https://urldefense.com/v3/__https://structura.bio/*team__;Iw!!Mih3wA!EOkZuuIALzxAHzrIjYj1ZqrDGOytr9ENngXszTEMGzBRfwTDaFrYWKP3u_YMy5uf0e0lVJ0gYwv1Ar18cb4M488dheM3$">The CryoSPARC Team</a><br><a href="https://urldefense.com/v3/__https://structura.bio/__;!!Mih3wA!EOkZuuIALzxAHzrIjYj1ZqrDGOytr9ENngXszTEMGzBRfwTDaFrYWKP3u_YMy5uf0e0lVJ0gYwv1Ar18cb4M4zpdJPXP$">Structura Biotechnology Inc</a>.<br></div>