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<strong><span style="font-family:"Arial",sans-serif;color:black;font-weight:normal">Dear all,</span></strong><b><span style="font-family:"Arial",sans-serif;color:black"><o:p></o:p></span></b></p>
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<span style="font-family:"Arial",sans-serif;color:black">We are looking for an outstanding postdoctoral research fellow to join the Fontana and Calabrese labs at the University of Leeds.
<o:p></o:p></span></p>
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<span style="font-family:"Arial",sans-serif;color:black"><a href="https://urldefense.com/v3/__https://www.jobs.ac.uk/job/CWN807/research-fellow-in-structural-biology__;!!Mih3wA!DBcdlxwitCKFFvhwLg49Rm3J95bvA-wLvWG-_8B4u4wEhHa0JxsUBSZepoFX68gWENwjXw9KJBHYoKxv-yBUOcDq$">https://www.jobs.ac.uk/job/CWN807/research-fellow-in-structural-biology</a><o:p></o:p></span></p>
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<span style="font-family:"Arial",sans-serif;color:black">The fellow will be part of a large team (£5.7M, funded by a BBSRC Strategic Longer and Larger grant). The team aims to unravel the ‘ribosome code’, rules that explain how compositionally dissecting ribosomes
enable translation of specific sets of mRNA. Specifically, the Research Fellow in Structural Biology will focus on the structural characterisation of the different ribosomes that we will purify during the project. This will include isolating specialised ribosomes
from a variety of organisms, and structurally characterising these ribosomes by cryo-electron microscopy and structural mass spectrometry. This will be possible by taking advantage of the state-of-the-art equipment available at the Astbury Biostructure Laboratory
(ABSL), which includes: two Titan Krios microscopes, equipped with Falcon 4 and Selectris Falcon 4 direct electron detectors; an Orbitrap Ultra-High Mass Range mass spectrometer (for native mass spectrometry of intact ribosomes); and a Orbitrap Eclipse mass
spectrometer (for cross-linking mass spectrometry). We anticipate that by understanding the structure of different specialised ribosomes, by exploiting our combined cryo-EM and mass spectrometry toolkit, we will be able to dissect conserved mechanisms of ribosome
specialisation across eukaryotes, allowing us to unravel the ‘ribosome code’.<o:p></o:p></span></p>
<p style="mso-margin-top-alt:0cm;margin-right:0cm;margin-bottom:12.0pt;margin-left:0cm;font-variant-ligatures: normal;font-variant-caps: normal;orphans: 2;text-align:start;widows: 2;-webkit-text-stroke-width: 0px;text-decoration-thickness: initial;text-decoration-style: initial;text-decoration-color: initial;word-spacing:0px">
<span style="font-family:"Arial",sans-serif;color:black">You must have a PhD (or close to completion) in RNA, translation, structural biology or a closely allied discipline; and experience in either cryo-electron microscopy or mass spectrometry applied to the
structural characterisation of macromolecules. You should also be willing to learn the other structural technique as the project will involve the use of both approaches.<o:p></o:p></span></p>
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<span style="font-family:"Arial",sans-serif;color:black">The University of Leeds and the Faculty of Biological Sciences are committed to providing equal opportunities for all and offer a range of <a href="https://urldefense.com/v3/__https://biologicalsciences.leeds.ac.uk/biological-sciences/doc/athena-swan/page/4__;!!Mih3wA!DBcdlxwitCKFFvhwLg49Rm3J95bvA-wLvWG-_8B4u4wEhHa0JxsUBSZepoFX68gWENwjXw9KJBHYoKxv-8M0kIQb$"><span style="color:#1D3661">family
friendly policies</span></a>. The University is a charter member of Athena SWAN (the national body that promotes gender equality in higher education), and the Faculty of Biological Sciences was awarded a Silver award in 2020. We are proud to be an inclusive
Faculty that values all staff, and are happy to consider job share applications and requests for flexible working arrangements from our employees. Our Athena SWAN <a href="https://urldefense.com/v3/__http://www.fbs.leeds.ac.uk/equality-and-diversity/athena-swan/__;!!Mih3wA!DBcdlxwitCKFFvhwLg49Rm3J95bvA-wLvWG-_8B4u4wEhHa0JxsUBSZepoFX68gWENwjXw9KJBHYoKxv-wPkFd-3$"><span style="color:#1D3661">webpage</span></a> provides
more information.<o:p></o:p></span></p>
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<strong><span style="font-family:"Arial",sans-serif;color:black">To explore the post further or for any queries you may have, please contact: </span></strong><span style="font-family:"Arial",sans-serif;color:black"><o:p></o:p></span></p>
<p style="mso-margin-top-alt:0cm;margin-right:0cm;margin-bottom:12.0pt;margin-left:0cm;font-variant-ligatures: normal;font-variant-caps: normal;orphans: 2;text-align:start;widows: 2;-webkit-text-stroke-width: 0px;text-decoration-thickness: initial;text-decoration-style: initial;text-decoration-color: initial;word-spacing:0px">
<span style="font-family:"Arial",sans-serif;color:black"><a href="https://urldefense.com/v3/__http://orcid.org/0000-0002-9084-2927__;!!Mih3wA!DBcdlxwitCKFFvhwLg49Rm3J95bvA-wLvWG-_8B4u4wEhHa0JxsUBSZepoFX68gWENwjXw9KJBHYoKxv-z2E0c-x$"><span style="color:#1D3661">Dr Juan Fontana</span></a>, Associate Professor.<o:p></o:p></span></p>
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<span style="font-family:"Arial",sans-serif;color:black">Tel: +44 (0)113 343 34170 | Email: <a href="mailto:j.fontana@leeds.ac.uk"><span style="color:#1D3661">j.fontana@leeds.ac.uk</span></a> <o:p></o:p></span></p>
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<p class="MsoNormal"><span lang="ES" style="font-family:"Arial",sans-serif;color:black;mso-fareast-language:EN-GB">Best,</span><span style="font-family:"Arial",sans-serif;color:black;mso-fareast-language:EN-GB"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="ES" style="font-family:"Arial",sans-serif;color:black;mso-fareast-language:EN-GB"> </span><span style="font-family:"Arial",sans-serif;color:black;mso-fareast-language:EN-GB"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="ES" style="font-family:"Arial",sans-serif;color:black;mso-fareast-language:EN-GB">Juan</span><span style="font-family:"Arial",sans-serif;color:black;mso-fareast-language:EN-GB"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="ES" style="font-family:"Arial",sans-serif;color:black;mso-fareast-language:EN-GB"> </span><span style="font-family:"Arial",sans-serif;color:black;mso-fareast-language:EN-GB"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="ES" style="font-family:"Arial",sans-serif;color:black;mso-fareast-language:EN-GB">-------------</span><span style="font-family:"Arial",sans-serif;color:black;mso-fareast-language:EN-GB"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="ES" style="font-family:"Arial",sans-serif;color:black;mso-fareast-language:EN-GB">Juan Fontana</span><span style="font-family:"Arial",sans-serif;color:black;mso-fareast-language:EN-GB"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif;color:black;mso-fareast-language:EN-GB">Garstang Building, Room 10.127<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif;color:black;mso-fareast-language:EN-GB">University of Leeds, Leeds, LS2 9JT, UK<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif;color:black;mso-fareast-language:EN-GB">Tel: +44 (0) 113 343 4170<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif;color:black;mso-fareast-language:EN-GB">Email: <a href="mailto:J.Fontana@leeds.ac.uk" title="mailto:J.Fontana@leeds.ac.uk"><span style="color:#0078D4">J.Fontana@leeds.ac.uk</span></a><o:p></o:p></span></p>
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