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<p class="MsoNormal"><font size="2" color="#212121" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;color:#212121"><o:p> </o:p></span></font></p>
<p class="MsoNormal"><font size="2" color="#212121" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;color:#212121">Dear all,<o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" color="#212121" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;color:#212121"><o:p> </o:p></span></font></p>
<p class="MsoNormal"><font size="2" color="#212121" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;color:#212121">here is an announcement for a cryo-EM specialist position
at the Centre for Integrative Biology, Strasbourg, France, to join an exciting structural biology environment with many challenging projects. Please see below for a description.<o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" color="#212121" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;color:#212121"><o:p> </o:p></span></font></p>
<p class="MsoNormal"><font size="2" color="#212121" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;color:#212121">This is also an opportunity to check whether the ccp4bb/em
mailing lists work again ;-)<o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" color="#212121" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;color:#212121"><o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" color="#212121" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;color:#212121">With best regards,<o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" color="#212121" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;color:#212121"><o:p> </o:p></span></font></p>
<p class="MsoNormal"><font size="2" color="#212121" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;color:#212121">Bruno Klaholz<o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" color="#212121" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;color:#212121"><o:p> </o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri"><o:p> </o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri"><o:p> </o:p></span></font></p>
<p class="MsoNormal" style="background:white"><u><font size="2" color="#212121" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;color:#212121">Cryo-EM specialist position:</span></font></u><font color="#212121"><span style="mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;color:#212121"><o:p></o:p></span></font></p>
<p class="MsoNormal" style="background:white"><font size="2" color="#212121" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;color:#212121">The CBI / IGBMC is seeking an experienced
cryo-EM scientist to participate in running the cutting-edge EM facilities at the Centre for Integrative Biology (CBI) at IGBMC, Illkirch/Strasbourg, France.<o:p></o:p></span></font></p>
<p class="MsoNormal" style="background:white"><font size="2" color="#212121" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;color:#212121"> <o:p></o:p></span></font></p>
<p class="MsoPlainText"><font size="2" color="#212121" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;color:#212121">The CBI
</span></font><span style="mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri"><a href="https://urldefense.com/v3/__https://www.igbmc.fr/en/plateformes-et-services/infrastructures/centre-for-integrative-biology__;!!Mih3wA!EepBkSYWS3XDrY5Jppt2diDiKwXf3Z_UOd_u_KnIU62EcgRim9605a72zZeZFELk-2m0aXDP5niQOSKdMw74$">https://www.igbmc.fr/en/plateformes-et-services/infrastructures/centre-for-integrative-biology</a><font color="#212121"><span style="color:#212121">
provides a leading-edge scientific and technological environment in integrated structural biology to address the structure and function of biological systems, notably on gene expression, from the atomic, molecular to the tissue scales. The platform for Integrated
Structural Biology at the CBI </span></font><a href="https://urldefense.com/v3/__https://biostructure.igbmc.fr/__;!!Mih3wA!EepBkSYWS3XDrY5Jppt2diDiKwXf3Z_UOd_u_KnIU62EcgRim9605a72zZeZFELk-2m0aXDP5niQOV4MnAq0$">https://biostructure.igbmc.fr/</a><font color="#212121"><span style="color:#212121"> provides support for protein sample production (bacterial, eukaryotic, mammalian cell
expression etc.), characterization and structural analysis using various approaches. The CBI hosts the French and European Infrastructures for Integrated Structural Biology, FRISBI
</span></font><a href="https://urldefense.com/v3/__https://frisbi.eu__;!!Mih3wA!EepBkSYWS3XDrY5Jppt2diDiKwXf3Z_UOd_u_KnIU62EcgRim9605a72zZeZFELk-2m0aXDP5niQOWXN089P$"><span style="mso-no-proof:yes">https://frisbi.eu</span></a>,
<font color="#212121"><span style="color:#212121">Instruct</span></font>-ERIC <a href="https://urldefense.com/v3/__http://instruct-eric.com/__;!!Mih3wA!EepBkSYWS3XDrY5Jppt2diDiKwXf3Z_UOd_u_KnIU62EcgRim9605a72zZeZFELk-2m0aXDP5niQOTzH8PG_$">
<span style="mso-bidi-font-weight:bold;mso-no-proof:yes">http://instruct-eric.com</span></a><font color="#212121"><span style="color:#212121"> </span></font>and iNext-Discovery
<a href="https://urldefense.com/v3/__https://inext-discovery.eu/__;!!Mih3wA!EepBkSYWS3XDrY5Jppt2diDiKwXf3Z_UOd_u_KnIU62EcgRim9605a72zZeZFELk-2m0aXDP5niQOUiKdsTv$"><span style="mso-no-proof:yes">https://inext-discovery.eu</span></a><font color="#212121"><span style="color:#212121">.
<o:p></o:p></span></font></span></p>
<p class="MsoPlainText"><font size="2" color="#212121" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;color:#212121"><o:p> </o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri">The advanced cryo-EM facility comprises
</span></font><span style="mso-ascii-font-family:Calibri;mso-fareast-font-family:"Times New Roman";mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri">cutting-edge instrumentation such as
</span><span style="mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri">two Titan Krios cryo electron microscopes and a Glacios cryo electron microscopes for cryo-EM and tomography,
</span><span style="mso-ascii-font-family:Calibri;mso-fareast-font-family:"Times New Roman";mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri">cryo Focused Ion Beam Scanning Electron Microscope (cryo-FIB/SEM) including for cryo FIB milling / lamella
production</span><span style="mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri">, and super-resolution imaging (dSTORM).<o:p></o:p></span></p>
<p class="MsoNormal"><font size="2" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri">The Titan Krios 1 microscope is equipped with K3 & Falcon 3 cameras and GIF energy filter,
Volta phase plate (VPP) and Cs corrector, <o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri">the Titan Krios 2 microscope has a Falcon 4i camera, Selectris X energy filter, Volta
phase plate (VPP),<o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri">the Glacios microscope has a K2 camera and a Ceta-D camera for micro electron diffraction
(ìED).<o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri">In addition, the EM facility has a suite of associated equipments for sample preparation
(grid freezing with Vitrobot and new Chameleon high-speed freezing device, HPF etc.) and dedicated computing resources for image analysis, processing and 3D reconstruction by single particle cryo-EM (including on-the-fly data processing), cryo electron tomography
(cryo-ET) and fluorescence microscopy, </span></font><span style="mso-ascii-font-family:Calibri;mso-fareast-font-family:"Times New Roman";mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri">and a dedicated opto-meca micromechanics workshop for developing
and prototyping new instruments.<span class="apple-converted-space"> </span><o:p></o:p></span></p>
<p class="MsoPlainText"><font size="2" color="#212121" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;color:#212121"><o:p> </o:p></span></font></p>
<p class="MsoPlainText"><font size="2" color="#212121" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;color:#212121">For projects and publications of the associated teams
see </span></font><span style="mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri"><a href="https://urldefense.com/v3/__http://igbmc.fr/research/department/3/__;!!Mih3wA!EepBkSYWS3XDrY5Jppt2diDiKwXf3Z_UOd_u_KnIU62EcgRim9605a72zZeZFELk-2m0aXDP5niQOXA6_AZN$">http://igbmc.fr/research/department/3/</a><font color="#212121"><span style="color:#212121">
<o:p></o:p></span></font></span></p>
<p class="MsoNormal" style="background:white"><font size="2" color="#212121" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;color:#212121"><o:p> </o:p></span></font></p>
<p class="MsoNormal" style="background:white"><font size="2" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-fareast-font-family:"Times New Roman";mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri">Interested candidates should
apply at </span></font><span style="mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri"><a href="https://urldefense.com/v3/__https://emploi.cnrs.fr/Offres/CDD/UMR7104-BETMOI-004/Default.aspx?lang=EN__;!!Mih3wA!EepBkSYWS3XDrY5Jppt2diDiKwXf3Z_UOd_u_KnIU62EcgRim9605a72zZeZFELk-2m0aXDP5niQOa_FwxVN$"><span style="mso-fareast-font-family:"Times New Roman"">https://emploi.cnrs.fr/Offres/CDD/UMR7104-BETMOI-004/Default.aspx?lang=EN</span></a></span><span style="mso-ascii-font-family:Calibri;mso-fareast-font-family:"Times New Roman";mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri">
and email a brief cover letter stating your interest, a CV with list of publications and names & contact information of three referees to
</span><span style="mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri"><a href="mailto:klaholz@igbmc.fr">klaholz@igbmc.fr</a><font color="#212121"><span style="color:#212121">.</span></font></span><span style="mso-ascii-font-family:Calibri;mso-fareast-font-family:"Times New Roman";mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri"><o:p></o:p></span></p>
<p class="MsoNormal"><font size="2" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri"><o:p> </o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri"><o:p> </o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;mso-fareast-language:EN-GB;mso-no-proof:yes"><o:p> </o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;mso-fareast-language:EN-GB;mso-no-proof:yes">###########################################################################<o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;mso-fareast-language:EN-GB;mso-no-proof:yes">Bruno P. Klaholz<o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;mso-fareast-language:EN-GB;mso-no-proof:yes">Centre for Integrative Biology<o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;mso-fareast-language:EN-GB;mso-no-proof:yes">Department of Integrated Structural Biology<br>
Institute of Genetics and of Molecular and Cellular Biology<br>
IGBMC - UMR 7104 - U 1258<o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;mso-fareast-language:EN-GB;mso-no-proof:yes">1, rue Laurent Fries<br>
BP 10142 <br>
67404 ILLKIRCH CEDEX<br>
FRANCE<o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;mso-fareast-language:EN-GB;mso-no-proof:yes">Tel. from abroad:<b><font color="red"><span style="color:red;font-weight:bold">
</span></font></b>0033.369.48.52.78<br>
Tel. inside France: 03.69.48.52.78<br>
websites:<br>
</span></font><span style="mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;mso-no-proof:yes"><a href="https://urldefense.com/v3/__http://www.igbmc.fr/Klaholz__;!!Mih3wA!EepBkSYWS3XDrY5Jppt2diDiKwXf3Z_UOd_u_KnIU62EcgRim9605a72zZeZFELk-2m0aXDP5niQOeSCF-8N$">http://www.igbmc.fr/Klaholz</a></span><span style="mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;mso-fareast-language:EN-GB;mso-no-proof:yes"><o:p></o:p></span></p>
<p class="MsoNormal"><font size="2" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;mso-no-proof:yes"><a href="https://urldefense.com/v3/__http://www.igbmc.fr/grandesstructures/cbi/__;!!Mih3wA!EepBkSYWS3XDrY5Jppt2diDiKwXf3Z_UOd_u_KnIU62EcgRim9605a72zZeZFELk-2m0aXDP5niQOQevvL8i$" target="_blank"><span style="mso-fareast-language:EN-GB">http://www.igbmc.fr/grandesstructures/cbi</span></a></span></font><span style="mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;mso-fareast-language:EN-GB;mso-no-proof:yes"><o:p></o:p></span></p>
<p class="MsoNormal"><font size="2" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;mso-no-proof:yes"><a href="https://urldefense.com/v3/__https://frisbi.eu__;!!Mih3wA!EepBkSYWS3XDrY5Jppt2diDiKwXf3Z_UOd_u_KnIU62EcgRim9605a72zZeZFELk-2m0aXDP5niQOWXN089P$"><span style="mso-fareast-language:EN-GB">https://frisbi.eu</span></a></span></font><span style="mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;mso-fareast-language:EN-US;mso-no-proof:yes"><o:p></o:p></span></p>
<p class="MsoNormal"><font size="2" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;mso-no-proof:yes"><a href="https://urldefense.com/v3/__http://instruct-eric.com/__;!!Mih3wA!EepBkSYWS3XDrY5Jppt2diDiKwXf3Z_UOd_u_KnIU62EcgRim9605a72zZeZFELk-2m0aXDP5niQOTzH8PG_$"><span style="mso-fareast-language:EN-GB;mso-bidi-font-weight:bold">http://instruct-eric.com</span></a><o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;mso-no-proof:yes"><a href="https://urldefense.com/v3/__https://inext-discovery.eu/__;!!Mih3wA!EepBkSYWS3XDrY5Jppt2diDiKwXf3Z_UOd_u_KnIU62EcgRim9605a72zZeZFELk-2m0aXDP5niQOUiKdsTv$">https://inext-discovery.eu</a><o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Calibri"><span style="font-size:11.0pt;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri"><o:p> </o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Calibri"><span style="font-size:11.0pt;mso-fareast-language:EN-US"><o:p> </o:p></span></font></p>
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