<html><head><meta http-equiv="Content-Type" content="text/html; charset=utf-8"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><br class=""><div><div class=""><div style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><p class="MsoHeader" style="line-height: 14pt;"><b class=""><span class="" style="font-size: 14pt; font-family: Arial, sans-serif;"><img apple-inline="yes" id="03CD6445-B2BC-4036-B40E-6580FB3DE68A" style="font-family: Helvetica; font-size: 12px;" src="cid:CBCAAE07-ADA7-49E5-AF5B-1200E04AA12D" class=""></span></b></p><p class="MsoHeader" style="line-height: 14pt;"><br class=""></p></div></div><div><p class="MsoHeader" style="line-height: 14pt;"><b class=""><span style="font-size: 14pt; font-family: Arial, sans-serif;" class="">Postdoctoral Positions in:<o:p class=""></o:p></span></b></p><p class="MsoHeader" style="margin-left: 0.5in; text-indent: -0.25in; line-height: 14pt;"><b class=""><span style="font-size: 14pt; font-family: Arial, sans-serif;" class="">1)<span style="font-weight: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: "Times New Roman";" class=""> </span></span></b><b class=""><span style="font-size: 14pt; font-family: Arial, sans-serif;" class="">Structural biology of ion channel assembly and chaperone interactions<o:p class=""></o:p></span></b></p><p class="MsoHeader" style="margin: 0in 0in 6pt 0.5in; text-indent: -0.25in; line-height: 14pt;"><b class=""><span style="font-size: 14pt; font-family: Arial, sans-serif;" class="">2)<span style="font-weight: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: "Times New Roman";" class=""> </span></span></b><b class=""><span style="font-size: 14pt; font-family: Arial, sans-serif;" class="">Structural studies and protein design of toxin sponge proteins<o:p class=""></o:p></span></b></p><p class="MsoNormal" style="margin-bottom: 6pt; text-align: justify;"><b class=""><span style="font-size: 11pt; font-family: Arial, sans-serif;" class="">MINOR LAB @UCSF</span></b><span style="font-size: 11pt; font-family: Arial, sans-serif;" class=""> - Cardiovascular Research Institute<o:p class=""></o:p></span></p><p class="MsoNormal" style="margin-bottom: 6pt; text-align: justify;"><b class=""><span style="font-size: 11pt; font-family: Arial, sans-serif;" class="">Multiple</span></b><span style="font-size: 11pt; font-family: Arial, sans-serif;" class=""> postdoctoral positions are available immediately for highly motivated individuals with strong backgrounds in biophysics, biochemistry, structural biology, or computational methods, and an interest in <b class="">structural biology of ion channel assembly mechanisms </b>or <b class="">structural studies and protein design of toxin sponge proteins</b> in the lab of <b class="">Prof. Dan Minor</b> at the <b class="">University of California, San Francisco</b> (<b class="">UCSF</b>). The Minor Lab merges structural, biochemical, chemical biology, genetic, and electrophysiological methods to dissect mechanisms of complex protein machines involved in electrical signaling and to uncover mechanisms of toxin resistance in poison organisms.<b class=""><o:p class=""></o:p></b></span></p><p class="MsoHeader" style="margin: 0in 0in 3pt 0.25in; text-indent: -0.25in;"><b class=""><span style="font-family: Arial, sans-serif;" class=""><font size="4" class="">1)<span style="font-weight: normal; font-stretch: normal; line-height: normal; font-family: "Times New Roman";" class=""> </span></font></span></b><b class=""><span style="font-family: Arial, sans-serif;" class=""><font size="4" class="">Structural biology of ion channel assembly</font><o:p class=""></o:p></span></b></p><p class="MsoNormal" style="margin-bottom: 3pt; text-align: justify;"><span style="font-size: 11pt; font-family: Arial, sans-serif;" class="">Projects focus on cryo-EM and other approaches to study the structural principles of ion channel assembly and interactions with chaperones. Candidates should have (or expect) an Ph.D. or M.D. and should have demonstrated achievements in<u class=""> protein biochemistry or biophysics, X-ray crystallography, cryo‑electronmicroscopy, or electrophysiology</u>. Computational skills are also highly desired.<b class=""><o:p class=""></o:p></b></span></p><p class="MsoNormal" style="margin-bottom: 3pt; text-align: justify;"><i class=""><span style="font-size: 11pt; font-family: Arial, sans-serif;" class="">Ongoing work is represented by: <o:p class=""></o:p></span></i></p><p class="MsoNormal" style="margin: 0in 0in 2pt 13.5pt; text-align: justify; line-height: 12pt;"><span style="font-size: 11pt; font-family: Arial, sans-serif; color: rgb(51, 51, 51); background-color: white;" class="">Arrigoni, C., Lolicato, M., Shaya, D., Rohaim, A., Findeisen, F., Fong, L.-K., Colleran, C.M., Dominik, P., Kim, S.S., Schuermann, J., DeGrado, W.F., Grabe, M., Kossiakoff, A.A., and <strong class=""><span style="border: 1pt none windowtext; padding: 0in;" class="">Minor, D.L., Jr.</span></strong></span> <span style="font-size: 11pt; font-family: Arial, sans-serif; color: rgb(51, 51, 51); background-color: white;" class="">'<em class=""><span style="border: 1pt none windowtext; padding: 0in;" class="">Quaternary structure independent folding of voltage-gated ion channel pore domain subunits'</span></em> <em class=""><span style="border: 1pt none windowtext; padding: 0in;" class="">Nature Structural and Molecular Biology</span></em> <strong class=""><span style="border: 1pt none windowtext; padding: 0in;" class="">29</span></strong> 537-548 (2022) </span><a href="https://www.nature.com/articles/s41594-022-00775-x" class=""><span style="font-size: 11pt; font-family: Arial, sans-serif; background-color: white;" class="">https://wsww.nature.com/articles/s41594-022-00775-x</span></a><span style="font-size: 11pt; font-family: Arial, sans-serif; color: rgb(51, 51, 51); background-color: white;" class=""> <strong class=""><o:p class=""></o:p></strong></span></p><p class="MsoNormal" style="margin: 0in 0in 2pt 13.5pt; text-align: justify; line-height: 12pt;"><span lang="IT" style="font-size: 11pt; font-family: Arial, sans-serif;" class=""><br class=""></span></p><p class="MsoNormal" style="margin: 0in 0in 2pt 13.5pt; text-align: justify; line-height: 12pt;"><span lang="IT" style="font-size: 11pt; font-family: Arial, sans-serif;" class="">Chen, Z., Mondal, A., Abderemane-Ali, F., Montano, J., Zaro, B., and Minor, D.L., Jr.,</span><b class=""><span lang="IT" style="font-size: 11pt; font-family: Arial, sans-serif; color: rgb(51, 51, 51); background-color: white;" class=""><o:p class=""></o:p></span></b></p><p class="MsoNormal" style="margin: 0in 0in 6pt 13.5pt; text-align: justify; line-height: 12pt;"><i class=""><span style="font-size: 11pt; font-family: Arial, sans-serif;" class="">’EMC holdase:Ca<sub class="">V</sub>1.2/Ca<sub class="">V</sub>β<sub class="">3</sub> complex and Ca<sub class="">V</sub>1.2 channel structures reveal Ca<sub class="">V</sub> assembly and drug binding mechanisms</span></i><span style="font-size: 11pt; font-family: Arial, sans-serif;" class="">’ </span><b class=""><span style="font-size: 11pt; font-family: Arial, sans-serif;" class="">bioRxiv</span></b><span style="font-size: 11pt; font-family: Arial, sans-serif;" class=""> </span><a href="https://www.biorxiv.org/content/10.1101/2022.10.03.510667v1" class=""><i class=""><span style="font-size: 11pt; font-family: Arial, sans-serif;" class="">https://www.biorxiv.org/content/10.1101/2022.10.03.510667v1</span></i></a><i class=""><span style="font-size: 11pt; font-family: Arial, sans-serif;" class=""><o:p class=""></o:p></span></i></p><p class="MsoHeader" style="margin: 0in 0in 3pt 0.25in; text-indent: -0.25in;"><font size="4" class=""><b class=""><span style="font-family: Arial, sans-serif;" class="">2)<span style="font-weight: normal; font-stretch: normal; line-height: normal; font-family: "Times New Roman";" class=""> </span></span></b><b class=""><span style="font-family: Arial, sans-serif;" class="">Structural studies and protein design of toxin sponge proteins<o:p class=""></o:p></span></b></font></p><p class="MsoNormal" style="margin-bottom: 3pt; text-align: justify;"><span style="font-size: 11pt; font-family: Arial, sans-serif;" class="">This project focuses on using structural biology, protein engineering, computational design, and molecular evolution to characterize and develop new toxin sponge proteins. Candidates should have (or expect) an Ph.D. or M.D. and should have demonstrated achievements in <u class="">protein structure analysis, protein biophysics, computational methods, or selection methods</u>. Computational skills are highly desired.<b class=""><o:p class=""></o:p></b></span></p><p class="MsoNormal" style="margin-bottom: 3pt; text-align: justify;"><i class=""><span style="font-size: 11pt; font-family: Arial, sans-serif;" class="">Ongoing work is represented by: </span></i><b class=""><span style="font-size: 11pt; font-family: Arial, sans-serif;" class=""><o:p class=""></o:p></span></b></p><p class="MsoNormal" style="margin-left: 13.5pt; text-align: justify; line-height: 12pt;"><span style="font-size: 11pt; font-family: Arial, sans-serif; background-color: white;" class="">Yen, T.-J., Lolicato, M., Thomas-Tran, R., Du Bois, J., and <strong class=""><span style="border: 1pt none windowtext; padding: 0in;" class="">Minor, D.L., Jr.</span></strong>, </span><b class=""><span style="font-size: 11pt; font-family: Arial, sans-serif; color: rgb(51, 51, 51); background-color: white;" class=""><o:p class=""></o:p></span></b></p><div style="margin: 0in 0in 0.1in 13.5pt; text-align: justify; line-height: 12pt;" class=""><span style="font-size: 11pt; font-family: Arial, sans-serif; background-color: white;" class="">'<em class=""><span style="border: 1pt none windowtext; padding: 0in;" class="">Structure of the Saxiphilin:saxitoxin (STX) complex reveals a convergent molecular recognition strategy for paralytic toxins</span></em>' <em class=""><span style="border: 1pt none windowtext; padding: 0in;" class="">Science Advances </span></em><strong class=""><span style="border: 1pt none windowtext; padding: 0in;" class="">5</span></strong>,<strong class=""><span style="border: 1pt none windowtext; padding: 0in;" class=""> </span></strong>eaax2650 (2019)</span> <a href="https://www.science.org/doi/10.1126/sciadv.aax2650" class=""><span style="font-size: 11pt; font-family: Arial, sans-serif; background-color: white;" class="">aax2650</span></a><strong class=""><span style="font-size: 11pt; font-family: Arial, sans-serif; color: rgb(51, 51, 51); background-color: white;" class=""><o:p class=""></o:p></span></strong></div><p class="MsoNormal" style="margin: 0in 0in 6pt 13.7pt; text-align: justify; line-height: 12pt;"><span style="font-size: 11pt; font-family: Arial, sans-serif;" class="">Chen, Z., Zakrzewska, S., Hajare, H., Alvarez-Bullya, A., Abderemane-Ali, F., Bogan, M., Ramirez, D., O’Connell, L.A., Du Bois, J., and<b class=""> </b>Minor, D.L., Jr.</span><b class=""><span style="font-size: 11pt; font-family: Arial, sans-serif; color: rgb(51, 51, 51); background-color: white;" class=""> </span></b><span style="font-size: 11pt; font-family: Arial, sans-serif;" class="">'<i class="">Definition of a saxitoxin (STX) binding code enables discovery and characterization of the Anuran saxiphilin family</i>’ <i class="">Proceedings of the National Academy of Sciences, USA </i><b class="">119 </b><i class="">e2210114119 </i>(2022)<i class=""> <a href="https://www.pnas.org/doi/10.1073/pnas.2210114119" class="">https://www.pnas.org/doi/10.1073/pnas.2210114119</a><o:p class=""></o:p></i></span></p><p class="MsoNormal" style="margin-bottom: 3pt; text-align: justify; line-height: 12pt;"><span style="font-size: 11pt; font-family: Arial, sans-serif;" class="">More information is available at the lab website </span><a href="http://www.cvri.ucsf.edu/~dminor/" class=""><b class=""><span style="font-size: 11pt; font-family: Arial, sans-serif;" class="">http://www.cvri.ucsf.edu/~dminor/</span></b></a><b class=""><span style="font-size: 11pt; font-family: Arial, sans-serif;" class=""><o:p class=""></o:p></span></b></p><p class="MsoNormal" style="margin-bottom: 3pt; text-align: justify; line-height: 12pt;"><span style="font-size: 11pt; font-family: Arial, sans-serif;" class="">Fellows will benefit from both the outstanding lab environment and the highly collaborative UCSF community.<b class=""><o:p class=""></o:p></b></span></p><p class="MsoNormal" style="margin-bottom: 3pt; text-align: justify; line-height: 12pt;"><b class=""><span style="font-size: 11pt; font-family: Arial, sans-serif;" class="">TO APPLY: </span></b><span style="font-size: 11pt; font-family: Arial, sans-serif;" class="">Interested individuals should send a current CV to Prof. Daniel Minor at </span><span style="font-size: 11pt; font-family: Arial, sans-serif; color: rgb(56, 110, 255);" class=""><a href="mailto:daniel.minor@ucsf.edu" class="">daniel.minor@ucsf.edu</a></span><u class=""><span style="font-size: 11pt; font-family: Arial, sans-serif; color: rgb(56, 110, 255);" class=""><o:p class=""></o:p></span></u></p><div class=""><br class=""></div></div></div><br class=""><div class="">
<div style="color: rgb(0, 0, 0); letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class="">Dan Minor, Ph.D.<br class="">Professor<br class="">Cardiovascular Research Institute<br class="">Departments of Biochemistry & Biophysics,<br class="">and Cellular & Molecular Pharmacology<br class="">California Institute for Quantitative Biomedical Research<br class="">Kavli Institute for Fundamental Neuroscience<br class="">University of California, San Francisco<br class=""><br class=""><br class="">FEDEX/UPS address:<br class=""><br class="">Cardiovascular Research Institute<br class="">Box 3122<br class="">University of California San Francisco<br class="">555 Mission Bay Blvd. South. Rm 452Z<br class="">San Francisco, CA 94158-9001<br class=""><br class=""><a href="mailto:daniel.minor@ucsf.edu" class="">Email: daniel.minor@ucsf.edu</a><br class="">Phone: 415-514-2551<br class="">Fax: 415-476-8173<br class="">Web: http://www.cvri.ucsf.edu/~dminor</div><div style="color: rgb(0, 0, 0); letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class="">Twitter:<a href="http://twitter.com/ElectrosomeUCSF" class="">http://twitter.com/ElectrosomeUCSF</a><br class=""><br class=""><br class=""></div>
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