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<b><span lang="EN-US" style="line-height: 22.4px; font-family: Garamond, serif; font-size: 15px;">D</span></b><b><span lang="EN-US" style="line-height: 22.4px; font-family: Garamond, serif; color: rgb(13, 13, 13);"><span style="font-size: 15px;">ear cryoEM
community,</span><font size="4"><o:p></o:p></font></span></b></p>
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<span lang="EN-US" style="font-size: 11pt; line-height: 17.6px; font-family: Garamond, serif; color: rgb(13, 13, 13);">The Boland & Loewith labs at the Department of Molecular and Cellular Biology at the University of Geneva (UNIGE), Switzerland are seeking
to appoint a joint postdoctoral fellow. <o:p></o:p></span></p>
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<span lang="EN-US" style="font-size: 11pt; line-height: 17.6px; font-family: Garamond, serif; color: rgb(13, 13, 13);">The two labs use structural biology methods together with complementary biophysical techniques (proteomics, light microscopy, expansion microscopy,
microfluidics, etc.) and molecular genetics to address complex biological questions in the field of cell metabolism and physiology. T</span><span style="font-size: 11pt; line-height: 17.6px; font-family: Garamond, serif; color: rgb(13, 13, 13);">he candidate </span><span lang="EN-GB" style="font-size: 11pt; line-height: 17.6px; font-family: Garamond, serif; color: rgb(13, 13, 13);">should
have a strong background in </span><span style="font-size: 11pt; line-height: 17.6px; font-family: Garamond, serif; color: rgb(13, 13, 13);">electron cryo</span><span lang="EN-GB" style="font-size: 11pt; line-height: 17.6px; font-family: Garamond, serif; color: rgb(13, 13, 13);">-</span><span style="font-size: 11pt; line-height: 17.6px; font-family: Garamond, serif; color: rgb(13, 13, 13);">tomography</span><span style="font-size: 11pt; line-height: 17.6px; font-family: Garamond, serif; color: rgb(13, 13, 13);"> <span lang="EN-GB">and
in </span></span><span style="font-size: 11pt; line-height: 17.6px; font-family: Garamond, serif; color: rgb(13, 13, 13);">cryo-EM single particle analysis</span><span lang="EN-GB" style="font-size: 11pt; line-height: 17.6px; font-family: Garamond, serif; color: rgb(13, 13, 13);">.
The successful candidate will have access to all instruments available at the <i>Dubochet Center for Imaging </i>(DCI), one of the </span><span lang="EN-US" style="font-size: 11pt; line-height: 17.6px; font-family: Garamond, serif; color: rgb(13, 13, 13);">most
modern and best equipped cryoEM hubs in Europe.</span><span lang="EN-GB" style="font-size: 11pt; line-height: 17.6px; font-family: Garamond, serif; color: rgb(13, 13, 13);"><o:p></o:p></span></p>
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<b><span lang="EN-US" style="line-height: 22.4px; font-family: Garamond, serif; color: rgb(13, 13, 13); font-size: 15px;">We offer:</span></b><span lang="EN-US" style="font-size: 14pt; line-height: 22.4px; font-family: Garamond, serif; color: rgb(13, 13, 13);"><o:p></o:p></span></p>
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<span lang="EN-US" style="font-size: 11pt; line-height: 17.6px; font-family: Garamond, serif; color: rgb(13, 13, 13);">The DCI is a joint initiative of the Universities of Geneva, Bern, and Lausanne, as well as the EPFL. The DCI offers access to several state-of-the-art
microscopes, such as a TFS Talos Arctica, two TFS Glacios and four TFS Titan Krios G4 microscopes. All high-end instruments are equipped with modern Falcon 4i detectors, Cold-FEG electron sources and SelectrisX energy filter. FIB-milling instruments are available
and future investments into the infrastructure, especially for <i>in situ</i> tomography studies are planned.<o:p></o:p></span></p>
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<span lang="EN-US" style="font-size: 11pt; line-height: 17.6px; font-family: Garamond, serif; color: rgb(13, 13, 13);">The UNIGE ranks among the world’s top scientific universities. Geneva is a beautiful, vibrant and highly international city on the shores
of the scenic Lake Geneva. Geneva frequently ranks amongst the cities with the highest life quality in the world! The UNIGE is committed to being an equal opportunity employer. The position is fully funded and offers a very competitive salary.<o:p></o:p></span></p>
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<b><span lang="EN-US" style="line-height: 22.4px; font-family: Garamond, serif; color: rgb(13, 13, 13); font-size: 15px;">Start date:</span></b><span lang="EN-US" style="font-size: 14pt; line-height: 22.4px; font-family: Garamond, serif; color: rgb(13, 13, 13);"><o:p></o:p></span></p>
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<span lang="EN-US" style="font-size: 11pt; line-height: 17.6px; font-family: Garamond, serif; color: rgb(13, 13, 13);">The position is available from May 2023, but the start date is flexible. Applications should be sent to </span><span lang="DE"><a href="mailto:Andreas.Boland@unige.ch" style="color: rgb(149, 79, 114);"><span lang="EN-US" style="font-size: 11pt; line-height: 17.6px; font-family: Garamond, serif; color: rgb(0, 112, 192);">Andreas.Boland@unige.ch</span></a></span><span lang="EN-US" style="font-size: 11pt; line-height: 17.6px; font-family: Garamond, serif; color: rgb(13, 13, 13);">or </span><span lang="DE"><a href="mailto:Robbie.Loewith@unige.ch" style="color: rgb(149, 79, 114);"><span lang="EN-US" style="font-size: 11pt; line-height: 17.6px; font-family: Garamond, serif; color: rgb(0, 112, 192);">Robbie.Loewith@unige.ch</span></a></span><span lang="EN-US" style="font-size: 11pt; line-height: 17.6px; font-family: Garamond, serif; color: rgb(0, 112, 192);"> </span><span lang="EN-US" style="font-size: 11pt; line-height: 17.6px; font-family: Garamond, serif; color: rgb(13, 13, 13);">and
include a Cover letter, CV, and the contact information for two references.<o:p></o:p></span></p>
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<b><span lang="EN-US" style="font-size: 11pt; line-height: 17.6px; font-family: Garamond, serif; color: rgb(13, 13, 13);">Related work references:<o:p></o:p></span></b></p>
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<span lang="EN-US" style="font-size: 11pt; line-height: 17.6px; font-family: Garamond, serif; color: rgb(13, 13, 13);">Tafur L, Hinterndorfer K, Gabus C, Lamanna C, Bergmann A, Sadian Y, Hamdi F, Kyrilis FL, Kastritis PL, <b>Loewith R.</b> (2022) <i>Cryo-EM
structure of the SEA complex.</i> <b><i>Nature</i></b>.<o:p></o:p></span></p>
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<span lang="EN-US" style="font-size: 11pt; line-height: 17.6px; font-family: Garamond, serif; color: rgb(13, 13, 13);">Yu J, Raia P*, Ghent CM*, Raisch T*, Sadian Y, Sabala PM, Barford D, Raunser S, Morgan DO, <b>Boland A.</b> (2021) <i>Structural basis of
human separase regulation by securin and Cdk1-cyclin B1</i>. <b><i>Nature</i></b>.<o:p></o:p></span></p>
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<b><span lang="EN-US" style="font-size: 11pt; font-family: Garamond, serif; color: rgb(13, 13, 13);">Boland A</span></b><span lang="EN-US" style="font-size: 11pt; font-family: Garamond, serif; color: rgb(13, 13, 13);">, Martin TG, Zhang Z, Yang J, Bai X-C,
Chang L, Scheres S, Barford D</span><span lang="EN-US" style="font-size: 11pt; font-family: Garamond, serif; color: rgb(13, 13, 13);"> </span><span lang="EN-US" style="font-size: 11pt; font-family: Garamond, serif; color: rgb(13, 13, 13);">(2017) <i>Cryo-EM
structure of a metazoan separase-securin complex at near-atomic resolution</i>. <b><i>NSMB</i>.</b></span><span lang="EN-US" style="font-size: 11pt; font-family: Garamond, serif; color: rgb(13, 13, 13);"><o:p></o:p></span></p>
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<span lang="EN-US" style="font-size: 11pt; line-height: 17.6px; font-family: Garamond, serif; color: rgb(13, 13, 13);">Prouteau M, Desfosses A, Sieben C, Bourgoint C, Lydia Mozaffari N, Demurtas D, Mitra AK, Guichard P, Manley S, <b>Loewith R.</b>(2017) <i>TORC1
organized in inhibited domains (TOROIDs) regulate TORC1 activity</i>. <b><i>Nature</i></b>.<o:p></o:p></span></p>
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<span lang="EN-US" style="font-size: 11pt; font-family: Garamond, serif; color: rgb(13, 13, 13);">With kind regards,<o:p></o:p></span></p>
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<b><span lang="EN-US" style="font-size: 11pt; font-family: Garamond, serif; color: rgb(13, 13, 13);">Andreas Boland and Robbie Loewith<o:p></o:p></span></b></p>
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