<html><head><meta http-equiv="content-type" content="text/html; charset=utf-8"></head><body style="overflow-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;">I may would think about a Zen-4 CPU like the 7950X. I don’t know how much Relion still profits from AVX512 but sadly Intel decided to disable that on the 13900K, the new AMDs support it now. Also the AMD has 4 more PCIe lanes, which may come in handy if you want more NVMe SSDs or update later to a second GPU. Though it only has DDR5 support which will cost more.<div><br><div>Apart from that air cooling is just as good, if not sometimes better, then AIO, and you need a good airflow in the case for the GPU anyway if u don’t plan to upgrade that also to a water block. Would recommend the good old Noctua fans.</div><div><br></div><div>For the GPU you may even get 2 older generation ones for the price of one 4090, so not sure its worth it (someone has benchmarks already?), also be sure to seat the power cable correctly/ check after delivery, could get crispy else ;)<br><div>
<div dir="auto" style="font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;"><div><br class="Apple-interchange-newline">Cheers</div><div>Kilian</div><div><br></div><div>Kilian Schnelle</div><div>Department of Structural Biology</div><div>University of Osnabrueck</div><div>Barbarastr. 13</div><div>D-49076 Osnabrueck, Germany</div><div>Phone: +49 541 969 7508</div><div>Email: kilian.schnelle@uni-osnabrueck.de</div><div><br></div></div><br class="Apple-interchange-newline" style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;"><br class="Apple-interchange-newline">
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<div><br><blockquote type="cite"><div>On 17. Nov 2022, at 13:25, Kovtun, Oleksiy <oleksiy.kovtun@mpinat.mpg.de> wrote:</div><br class="Apple-interchange-newline"><div>
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<div>Dear all, </div>
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<div>I am configuring mid-performance systems for SPA and STA processing. </div>
<div>Systems are aimed at testing processing parameters and processing small to medium datasets in frugal box sizes. They will be installed in an office and serve as individual workstations. </div>
<div>Currently, I come down to the following:</div>
<div>i9-13900k AIO cooling, 128GB DDR4-3200, 4TB SSD scratch, 10GB LAN. </div>
<div>For the GPU, I consider 24GB cards: </div>
<div>RTX 3090 - the basic choice. </div>
<div>RTX 3090ti - much extra heat for nothing, but surprisingly more available than 3090. </div>
<div>RTX4090 - will this perform better in RELION? Extra CUDA cores, but the same VRAM size and bandwidth as 3090. It may run cooler and quieter, though. Has anyone had a successful installation, and RELION runs on it? </div>
<div>RTX A5000 - a step price overhead for overheating insurance. It may be a necessary evil for an office-based PC. </div>
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<div>Please let me know what option will be better and whether the core system configuration ( is BIG.Little of i9 a problem? ) looks adequate. </div>
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<div>Thank you and best, </div>
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<div>Oleksiy </div>
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<i><b>Dr Oleksiy Kovtun<br>
</b>Max-Planck Research Group Leader<br>
Molecular Mechanisms of Membrane Trafficking<br>
Max-Planck-Institute for Multidisciplinary Sciences<br>
City-Campus, Hermann-Rein-Str. 3, 37075 Göttingen<br>
Germany<br>
<a href="mailto:oleksiy.kovtun@mpinat.mpg.de">Email: oleksiy.kovtun@mpinat.mpg.de</a></i></div>
<div><i><a href="https://urldefense.com/v3/__https://www.mpinat.mpg.de/kovtun__;!!Mih3wA!CbOW6OOOAtgDvIc-lEOacmcS-11n9OwbtCkwe7JJ8DsanPBfuO-w0il-Waib9M5gGazqgCuzcPBTBcJfLOjmsBUtSQxLZaK61Q$">https://www.mpinat.mpg.de/kovtun</a><br>
Phone:+49-551-3899-410<br>
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