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<p class="MsoNormal"><span lang="EN-US" style="font-family:Roboto">Dear all,<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-family:Roboto"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-family:Roboto">When you are passionate about cryo-EM and sample preparation and technology we have a special webinar coming up next week Thursday November 10<sup>th</sup>: More information below and how to
secure your free spot. <o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-family:Roboto"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-family:Roboto">The CryoSol Community welcomes you to share knowledge about sample preparation for cryo-EM and learn from each other. We believe this is vital to advance cryo-electron microscopy (cryo-EM) research.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-family:Roboto">Our Community is open to share publications, new insights and practical knowledge to innovate cryo-EM sample preparation. Please reach out to me when you want to share your publications within
our community or become a speaker in one of our next webinars as well.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-family:Roboto"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-family:Roboto"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-family:Roboto">WEBINAR THURSDAY NOVEMBER 10, 2022<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-family:Roboto">Vitrobot. VitroJet: Meet the Maker<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-family:Roboto"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-family:Roboto">When:<o:p></o:p></span></p>
<ul style="margin-top:0cm" type="disc">
<li class="MsoListParagraph" style="margin-left:0cm;mso-list:l0 level1 lfo1"><span lang="EN-US" style="font-family:Roboto">16:00 PM CET</span><span lang="EN-US">
</span><span lang="EN-US" style="font-family:Roboto"><o:p></o:p></span></li><li class="MsoListParagraph" style="margin-left:0cm;mso-list:l0 level1 lfo1"><span lang="EN-US" style="font-family:Roboto">10:00 AM EST<o:p></o:p></span></li><li class="MsoListParagraph" style="margin-left:0cm;mso-list:l0 level1 lfo1"><span lang="EN-US" style="font-family:Roboto">07:00 AM PST<o:p></o:p></span></li></ul>
<p class="MsoNormal"><span lang="EN-US" style="font-family:Roboto"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-family:Roboto">We are very happy to welcome our guest speaker Frank Nijpels, R&D developer and the inventor of numerous scientific and medical instruments. Frank was co-inventor of the Vitrobot when working
at the Maastricht University in The Netherlands. With the expansion of cryo-EM in the 20 years after the invention of the blotting device, it became clear a new approach to sample preparation was needed to bring this process under control. Frank was not only
a co-inventor of the instrument but also a perpetual user and understood well the weaknesses of the different makes of the plunging devices. His experience was confirmed by other cryo-EM scientists: from the excessive sample needed, irreproducible blotting
results, lack of temperatures control and filling procedure of the ethane cup, to the post clipping of the grids in liquid nitrogen - things had to change! The birth of a new technology was not a nine-month journey. Frank explains why his dedication to the
techniques meant that sample deposition, vitrification, grid handling and automation needed development. Testing was long and complicated as various techniques were tried and tested in depositing and vitrifying biological samples. Years of research and experiments
led him and the team to a new technology which opened up the possibilities to create an automated sample preparation solution for anyone to achieve control and reproducibility. It is a platform ready for future needs and therefore a new way forward in sample
preparation. The webinar will be hosted by Giulia Weissenberger, Product Manager at CryoSol-World and responsible for the roadmap of the sample preparation solutions for cryo-EM.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-family:Roboto"><o:p> </o:p></span></p>
<p class="MsoNormal"><i><span lang="EN-US" style="font-family:Roboto">About Frank Nijpels:<o:p></o:p></span></i></p>
<p class="MsoNormal"><i><span lang="EN-US" style="font-family:Roboto">Frank was co-author of the article in VitroJet Nat Comms paper: Ravelli RBG, Nijpels FJT, Henderikx RJM, et al.<o:p></o:p></span></i></p>
<p class="MsoNormal"><i><span lang="EN-US" style="font-family:Roboto">Cryo-EM structures from sub-nl volumes using pin-printing and jet vitrification. Nature Communications. 2020 May;11(1):2563. DOI: 10.1038/s41467-020-16392-5. PMID: 32444637; PMCID: PMC7244535.<o:p></o:p></span></i></p>
<p class="MsoNormal"><span lang="EN-US" style="font-family:Roboto"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-family:Roboto">Just enter your email address to secure your free spot VIA THIS LINK:
<a href="https://urldefense.com/v3/__https://app.livestorm.co/p/d43c126c-ff4e-459d-ac36-81543182ff00__;!!Mih3wA!Fk3Oq10rJ0mUM7zW3f41rhl9Uf3JXfNgOrvYq6xbfH6RnDFSmO1GbXhPUpJyVGh_eEAwTkHmQVYPAOYMFIYk6ERy4BxXFvbjNCNe$">https://app.livestorm.co/p/d43c126c-ff4e-459d-ac36-81543182ff00</a><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-family:Roboto"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-family:Roboto">After the presentation our speakers will answer questions in our live Q&A. We also like to hear your needs and suggestions for future directions to improve the cryo-EM sample preparation within
the community together. Because two achieve more.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-family:Roboto"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-family:Roboto">With kind regards,<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;background:white">
<span lang="EN-US" style="font-family:Roboto;color:#0C64C0;mso-fareast-language:NL">Marilla Ruczynski</span><span lang="EN-US" style="font-family:Roboto;color:#174E86;mso-fareast-language:NL"> </span><span lang="EN-US" style="mso-fareast-language:NL"><o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;background:white">
<span lang="EN-US" style="font-size:11.5pt;font-family:Roboto;color:black;mso-fareast-language:NL">Marketing Manager CryoSol-World</span><span lang="EN-US" style="font-size:11.5pt;font-family:Roboto;color:#326FB5;mso-fareast-language:NL"> </span><span lang="EN-US" style="font-size:8.0pt;font-family:Roboto;color:#323130;mso-fareast-language:NL"> </span><span lang="EN-US" style="mso-fareast-language:NL"><o:p></o:p></span></p>
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<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:10.5pt;font-family:Roboto;color:#333333;background:white;mso-fareast-language:NL">+31 (0) 6 188 99 929</span><span style="mso-fareast-language:NL"><o:p></o:p></span></p>
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