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<p class="MsoNormal">H Everyone,<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">Please join us the upcoming Cancer therapeutics webinar with Dr. Basil Greber on Oct 18:<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p style="mso-margin-top-alt:0in;margin-right:0in;margin-bottom:15.0pt;margin-left:0in;background:white">
<span style="font-size:10.5pt;color:black">Dr. Basil Greber from the Institute of Cancer Research in London, UK, will demonstrate how the Glacios 2 Cryo-TEM facilitated the discovery of next-generation therapeutics. <o:p></o:p></span></p>
<p style="mso-margin-top-alt:0in;margin-right:0in;margin-bottom:15.0pt;margin-left:0in;background:white;font-variant-ligatures: normal;font-variant-caps: normal;orphans: 2;text-align:start;widows: 2;-webkit-text-stroke-width: 0px;text-decoration-thickness: initial;text-decoration-style: initial;text-decoration-color: initial;word-spacing:0px">
<span style="font-size:10.5pt;color:black">Dr. Greber and his team used the Glacios 2 Cryo-TEM in their efforts to make CDK-activating kinase (CAK) amenable to structure-based drug design. First, they determined the structures of the human CAK bound to nucleotide
analogues and two inhibitors. They then used the Glacios 2 Cryo-TEM equipped with a Thermo Scientific Selectris X Imaging Filter and a Thermo Scientific Falcon 4i Direct Electron Detector to uncover the structural basis of inhibitor selectivity, which required
rapid acquisition of high-quality datasets for large numbers of different inhibitors.<o:p></o:p></span></p>
<p style="mso-margin-top-alt:0in;margin-right:0in;margin-bottom:15.0pt;margin-left:0in;background:white;font-variant-ligatures: normal;font-variant-caps: normal;orphans: 2;text-align:start;widows: 2;-webkit-text-stroke-width: 0px;text-decoration-thickness: initial;text-decoration-style: initial;text-decoration-color: initial;word-spacing:0px">
<span style="font-size:10.5pt;color:black">This workflow enabled 3D reconstruction of the CAK at 3.5 to 4.5 Å resolution within one hour from the start of data collection and at approximately 3 Å resolution within four hours. Finally, they obtained more than
a dozen high-resolution structures of the 85 kDa CDK-cyclin-module of the human CAK bound to inhibitors and nucleotides at up to 1.8 Å resolution using a Thermo Scientific Krios G4 Cryo-TEM with a cold-FEG. These structures provided detailed insight into inhibitor
binding and suggested a mechanism for target selectivity that they are currently testing.<o:p></o:p></span></p>
<p class="MsoNormal"><a href="https://urldefense.com/v3/__https://www.thermofisher.com/us/en/home/about-us/events/industrial/ls-cryo-electron-microscopy.html__;!!Mih3wA!EEE6zGi-C4b-te5dE-NPI0ZHWT-PeIotti1KYGGWnoK2FpqL_Q9-59VmA3_JMCSvpTW1vpIMg4nXKT3M27-rf7oU56KEbwtQBQ$">Register here!</a><o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">Best regards,<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">Jeff<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><span style="font-size:13.5pt;color:black">____________________________________________________________________<o:p></o:p></span></p>
<p class="MsoNormal"><b><span style="font-family:"Arial",sans-serif;color:black">Jeffrey Lengyel, Ph.D.</span></b><span style="font-family:"Arial",sans-serif;color:black"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black">Director, Product Marketing, Cryo-EM, Electron Microscopy Life Sciences<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black">Materials & Structural Analysis<o:p></o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black"><o:p> </o:p></span></b></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black">Thermo Fisher Scientific<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black">5350 NE Dawson Creek Drive | Hillsboro, OR 97124<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black">Phone </span><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black">503 560 9184 <o:p></o:p></span></p>
<p class="MsoNormal"><a href="mailto:Jeffrey.Lengyel@thermofisher.com"><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:blue">Jeffrey.Lengyel@thermofisher.com</span></a><o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><a href="https://urldefense.com/v3/__https://www.thermofisher.com/us/en/home/electron-microscopy/products/transmission-electron-microscopes/glacios-cryo-tem.html__;!!Mih3wA!EEE6zGi-C4b-te5dE-NPI0ZHWT-PeIotti1KYGGWnoK2FpqL_Q9-59VmA3_JMCSvpTW1vpIMg4nXKT3M27-rf7oU56Jcm6ajCg$"><span style="color:windowtext;text-decoration:none"><img border="0" width="480" height="100" style="width:5.0in;height:1.0416in" id="Picture_x0020_3" src="cid:image001.jpg@01D8E216.356132F0" alt="Text
Description automatically generated"></span></a><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black"><o:p></o:p></span></p>
<p class="MsoNormal"><o:p> </o:p></p>
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