<html><head><meta http-equiv="Content-Type" content="text/html; charset=utf-8"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><div class=""><br class=""></div><div class="">This looks quite a bit like ‘clusters of metal nanoparticles’ — something I’ve looked at quite a bit in the EM. I take it from your question that you’re not expecting to see metal clusters / metal nanoparticles in your sample?</div><div class=""><br class=""></div><div class="">Cheers,</div><div class="">Chris</div><br class=""><div><br class=""><blockquote type="cite" class=""><div class="">On Oct 10, 2022, at 6:45 AM, <<a href="mailto:r.i.koning@lumc.nl" class="">r.i.koning@lumc.nl</a>> <<a href="mailto:r.i.koning@lumc.nl" class="">r.i.koning@lumc.nl</a>> wrote:</div><br class="Apple-interchange-newline"><div class=""><meta charset="UTF-8" class=""><div class="WordSection1" style="page: WordSection1; caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none;"><div style="margin: 0cm; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span lang="EN-US" class="">Dear all,<o:p class=""></o:p></span></div><div style="margin: 0cm; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span lang="EN-US" class=""><o:p class=""> </o:p></span></div><div style="margin: 0cm; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span lang="EN-US" class="">I would like to have you expert opinion on what the structures in the attached image might be. The structures are quite dense in my opinion. I have my ideas but I am not at all sure. I hope any of you have seen similar structures.<span class="Apple-converted-space"> </span><o:p class=""></o:p></span></div><div style="margin: 0cm; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span lang="EN-US" class=""><o:p class=""> </o:p></span></div><div style="margin: 0cm; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span lang="EN-US" class="">Best regards,<o:p class=""></o:p></span></div><div style="margin: 0cm; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span lang="EN-US" class=""><o:p class=""> </o:p></span></div><div style="margin: 0cm; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span lang="EN-US" class="">Roman<span class="Apple-converted-space"> </span><o:p class=""></o:p></span></div><div style="margin: 0cm; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span lang="EN-US" class=""><o:p class=""> </o:p></span></div><div style="margin: 0cm; font-size: 11pt; font-family: Calibri, sans-serif; text-align: center;" class=""><b class=""><span lang="EN-US" style="font-size: 10pt; font-family: Arial, sans-serif; color: gray;" class="">Dr. R.I.Koning<o:p class=""></o:p></span></b></div><div style="margin: 0cm; font-size: 11pt; font-family: Calibri, sans-serif; text-align: center;" class=""><span lang="EN-US" style="font-size: 8pt; color: gray;" class=""><o:p class=""> </o:p></span></div><div style="margin: 0cm; font-size: 11pt; font-family: Calibri, sans-serif; text-align: center;" class=""><span lang="EN-GB" style="font-size: 8pt; font-family: Arial, sans-serif; color: gray;" class="">Leiden University Medical Center, Cell and Chemical Biology, Electron Microsc</span><span lang="EN-US" style="font-size: 8pt; font-family: Arial, sans-serif; color: gray;" class="">opy</span><span lang="EN-US" style="font-size: 8pt; color: gray;" class=""><o:p class=""></o:p></span></div><div style="margin: 0cm; font-size: 11pt; font-family: Calibri, sans-serif; text-align: center;" class=""><span lang="EN-US" style="font-size: 8pt; font-family: Arial, sans-serif; color: gray;" class="">Postal Zone S1-P, P.O.Box 9600, 2300 RC, Leiden, The Netherlands<o:p class=""></o:p></span></div><div style="margin: 0cm; font-size: 11pt; font-family: Calibri, sans-serif; text-align: center;" class=""><span lang="EN-US" style="font-size: 8pt; font-family: Arial, sans-serif; color: gray;" class=""><o:p class=""> </o:p></span></div><div style="margin: 0cm; font-size: 11pt; font-family: Calibri, sans-serif; text-align: center;" class=""><b class=""><span lang="EN-US" style="font-size: 8pt; font-family: Arial, sans-serif; color: gray;" class="">visiting address.</span></b><span lang="EN-US" style="font-size: 8pt; font-family: Arial, sans-serif; color: gray;" class=""><span class="Apple-converted-space"> </span>Einthovenweg 20, Building 2, zone S1-P, room R-90-21<o:p class=""></o:p></span></div><div style="margin: 0cm; font-size: 11pt; font-family: Calibri, sans-serif; text-align: center;" class=""><b class=""><span lang="EN-US" style="font-size: 8pt; font-family: Arial, sans-serif; color: gray;" class="">tel.</span></b><span lang="EN-US" style="font-size: 8pt; font-family: Arial, sans-serif; color: gray;" class=""><span class="Apple-converted-space"> </span>(31) 71 526 9296<span class="Apple-converted-space"> </span><b class="">fax.</b><span class="Apple-converted-space"> </span>(+31) 71 526 8270<span class="Apple-converted-space"> </span><b class="">mail.<span class="Apple-converted-space"> </span></b></span><span lang="EN-US" class=""><a href="mailto:r.i.koning@lumc.nl" class=""><span style="font-size: 8pt; font-family: Arial, sans-serif; color: blue;" class="">r.i.koning@lumc.nl</span></a></span><span lang="EN-US" style="font-size: 8pt; font-family: Arial, sans-serif; color: gray;" class=""><span class="Apple-converted-space"> </span><b class="">web.</b><span class="Apple-converted-space"> </span></span><span lang="EN-US" class=""><a href="https://urldefense.com/v3/__http://www.kosterlab.nl/__;!!Mih3wA!F4lNir_quXjQA0OCOnJTcn8SALwmpJlIYa7sS_mNNlUXvFr8spA-OUWkVBosGs3LAI6wkv09XnIncfYrM5h64LI$" class=""><span style="font-size: 8pt; 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