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<div dir="auto"><span style="color:black;font-family:Arial, sans-serif;font-size: 11pt">Dear Colleagues,</span></div>

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<div style="text-align:justify;font-size: 11pt"><span style="color:#333333;background-color:white;font-family:Arial, sans-serif;font-size: 11pt">The </span><span style="color:black;background-color:white;font-family:Arial, sans-serif;font-size: 11pt">Laboratory for BioMolecular Structure (LBMS) </span><span style="color:black;font-family:Arial, sans-serif;font-size: 11pt">at Brookhaven National Laboratory (BNL)</span><span style="color:black;background-color:white;font-family:Arial, sans-serif;font-size: 11pt"> will host </span><span style="color:black;font-family:Arial, sans-serif;font-size: 11pt">a four-day VIRTUAL Cryo-Electron Microscopy </span><span style="color:black;background-color:white;font-family:Arial, sans-serif;font-size: 11pt">(cryo-EM) course from June 14 </span><span style="color:black;font-family:Arial, sans-serif;font-size: 11pt">-</span><span style="color:black;background-color:white;font-family:Arial, sans-serif;font-size: 11pt"> 17, 2022</span><span style="color:black;font-family:Arial, sans-serif;font-size: 11pt">. </span></div>

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<div style="text-align:justify;font-size: 11pt"><span style="color:black;font-family:Arial, sans-serif;font-size: 11pt">This course will introduce high-resolution Cryo-EM to the structural biology research community.  It will include image formation and three-dimensional reconstruction theories and available software, tutorials, and demonstrations for data collection and analysis. </span></div>

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<div style="text-align:justify;font-size: 11pt"><span style="color:black;font-family:Arial, sans-serif;font-size: 11pt">Confirmed speakers and instructors include: </span></div>

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<div style="text-align:justify;font-size: 11pt"><span style="color:black;font-family:Arial, sans-serif;font-size: 11pt">David DeRosier, Brandeis University</span></div>

<div style="text-align:justify;font-size: 11pt"><span style="color:black;font-family:Arial, sans-serif;font-size: 11pt">Chen Xu, Umess</span></div>

<div style="text-align:justify;font-size: 11pt"><span style="color:black;font-family:Arial, sans-serif;font-size: 11pt">Tamir Gonen,</span><span style="color:#000000;font-family:Calibri, sans-serif;font-size: 11pt"> </span><span style="color:black;font-family:Arial, sans-serif;font-size: 11pt">UCLA</span></div>

<div style="text-align:justify;font-size: 11pt"><span style="color:black;font-family:Arial, sans-serif;font-size: 11pt">Gabriel Lander, Scripps Research</span></div>

<div style="text-align:justify;font-size: 11pt"><span style="color:black;font-family:Arial, sans-serif;font-size: 11pt">Oliver Clarke, Columbia University</span></div>

<div style="text-align:justify;font-size: 11pt"><span style="color:black;font-family:Arial, sans-serif;font-size: 11pt">Dongyan Tan, Stony Brook University</span></div>

<div style="text-align:justify;font-size: 11pt"><span style="color:black;font-family:Arial, sans-serif;font-size: 11pt">Jun Liu, Yale University</span></div>

<div style="text-align:justify;font-size: 11pt"><span style="color:black;font-family:Arial, sans-serif;font-size: 11pt">Digvijay Singh, UCSD</span></div>

<div style="text-align:justify;font-size: 11pt"><span style="color:black;font-family:Arial, sans-serif;font-size: 11pt">Jianfeng Lin, Yale University</span></div>

<div style="text-align:justify;font-size: 11pt"><span style="color:black;font-family:Arial, sans-serif;font-size: 11pt">Raphael Park, Yale University</span></div>

<div style="text-align:justify;font-size: 11pt"><span style="color:black;font-family:Arial, sans-serif;font-size: 11pt">Muyan Chen, Baylor College of Medicine</span></div>

<div style="text-align:justify;font-size: 11pt"><span style="color:black;font-family:Arial, sans-serif;font-size: 11pt">Yong Xiong, Yale University</span></div>

<div style="text-align:justify;font-size: 11pt"><span style="color:black;font-family:Arial, sans-serif;font-size: 11pt">Qun Liu, Brookhaven National Laboratory</span></div>

<div style="text-align:justify;font-size: 11pt"><span style="color:black;font-family:Arial, sans-serif;font-size: 11pt">Guobin Hu, Brookhaven National Laboratory</span></div>

<div style="text-align:justify;font-size: 11pt"><span style="color:black;font-family:Arial, sans-serif;font-size: 11pt">Liguo Wang, Brookhaven National Laboratory</span></div>

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<div dir="auto"><span style="color:black;font-family:Arial, sans-serif;font-size: 11pt">The full schedule can be found at </span><a style="font-family:Arial, sans-serif;font-size: 11pt" href="https://urldefense.proofpoint.com/v2/url?u=https-3A__www.bnl.gov_cryoemcourse_files_pdf_agenda.pdf&d=DwMFaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=zFOu8DtJJAj73m8mFyuqIG1JeVtmODLwNKA3z1K0Fp81yhWiB0Ab-bS4mQ2ko5V0&s=TiRgEiD_WDoTil-_GHYoJ14E-8N4m4_MZzj6G2hgGow&e=" target="_blank">https://www.bnl.gov/cryoemcourse/files/pdf/agenda.pdf</a><span style="color:black;font-family:Arial, sans-serif;font-size: 11pt">. The course is free of charge, but you will need to register here: </span><a style="font-family:Arial, sans-serif;font-size: 11pt" href="https://urldefense.proofpoint.com/v2/url?u=https-3A__www.bnl.gov_cryoemcourse_&d=DwMFaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=zFOu8DtJJAj73m8mFyuqIG1JeVtmODLwNKA3z1K0Fp81yhWiB0Ab-bS4mQ2ko5V0&s=BrUWoMUfd5MLfV3qzlc3UoG2LTxBYaui88UVG7aOinE&e=" target="_blank">https://www.bnl.gov/cryoemcourse/</a><span style="color:black;font-family:Arial, sans-serif;font-size: 11pt">.</span></div>

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<div style="text-align:justify;font-size: 11pt"><span style="color:black;font-family:Arial, sans-serif;font-size: 11pt">Best regards,</span></div>

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<div style="text-align:justify;font-size: 11pt"><span style="color:black;font-family:Arial, sans-serif;font-size: 11pt">Cryo-EM course organizing committee </span></div>

<div dir="auto"><span style="color:#333333;font-family:Arial, sans-serif;font-size: 11pt">Liguo Wang (BNL)</span><span style="font-size: 11pt"><br /></span><span style="color:#333333;font-family:Arial, sans-serif;font-size: 11pt">Qun Liu (BNL)</span><span style="font-size: 11pt"><br /></span><span style="color:#333333;font-family:Arial, sans-serif;font-size: 11pt">Guobin Hu (BNL)</span><span style="font-size: 11pt"><br /></span><span style="color:#333333;font-family:Arial, sans-serif;font-size: 11pt">Jake Kaminsky (BNL)</span><span style="font-size: 11pt"><br /></span><span style="color:#333333;font-family:Arial, sans-serif;font-size: 11pt">Dongyan Tan (Stony Brook)</span><span style="font-size: 11pt"><br /></span><span style="color:#333333;font-family:Arial, sans-serif;font-size: 11pt">Jun Liu (Yale)</span><span style="font-size: 11pt"><br /></span><span style="color:#333333;font-family:Arial, sans-serif;font-size: 11pt">Yong Xiong (Yale)</span><span style="font-size: 11pt"><br /></span><span style="color:black;font-family:Arial, sans-serif;font-size: 11pt"> </span><span style="font-size: 11pt"><br /></span><span style="color:#333333;font-family:Arial, sans-serif;font-size: 11pt">Laboratory for BioMolecular Structure (LBMS)</span><span style="font-size: 11pt"><br /></span><span style="color:#333333;font-family:Arial, sans-serif;font-size: 11pt">Brookhaven National Laboratory (BNL)</span><span style="font-size: 11pt"><br /></span><a style="font-family:Arial, sans-serif;font-size: 11pt" href="https://urldefense.com/v3/__https:/www.bnl.gov/cryo-em/__;!!Mih3wA!S4dX4yy-Xhdsio37l7TdU6hEFoA48r1PNle5mdHV4wSvIBRTtUw7BTnRJK3PqxM$" target="_blank">https://www.bnl.gov/cryo-em/</a></div>

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<div class="matchFont">Liguo Wang</div>

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