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<p class="MsoNormal"><span style="font-size:11.0pt">Dear colleagues, <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt">please find below details for a postdoc position in the Thalassinos lab at UCL.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Best<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Giulia<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><b>Post doctoral researcher in Structural Biology (CryoEM/MS) - DNA Repair and Huntington's disease.<o:p></o:p></b></p>
<p class="MsoNormal" style="text-align:justify"><o:p> </o:p></p>
<p class="MsoNormal" style="text-align:justify">We seek to appoint a Postdoctoral Research Fellow to the research team led by Prof Konstantinos Thalassinos (<a href="https://urldefense.proofpoint.com/v2/url?u=http-3A__www.homepages.ucl.ac.uk_-7Eucbtkth_&d=DwQFAg&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=HKcQosCXSmu4Y06jcQxjEDiuHr-GP47mJDYBIpwBkyKFXfb9Ft6gns4U6FwLuj5W&s=gnUKdcDQQep-5Ztq6Iub10O5bnfNe3UVcgK8YXh-Fck&e=">http://www.homepages.ucl.ac.uk/~ucbtkth/</a>), based at University College London. The position is funded
by the CHDI Foundation (<a href="https://urldefense.proofpoint.com/v2/url?u=https-3A__chdifoundation.org&d=DwQFAg&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=HKcQosCXSmu4Y06jcQxjEDiuHr-GP47mJDYBIpwBkyKFXfb9Ft6gns4U6FwLuj5W&s=7h7gCgMoY0I3r6wf0KiVZ4NOJFWFEf604-RaMEkiTco&e=">https://chdifoundation.org</a>) for 3 years and is available from 1st May 2022. The successful applicant will undertake the structural characterisation of protein complexes involved in DNA repair. This project follows on from our recently
published work (Goold <i>et al.,</i> 2021) where we identified new protein interactions important for modulating CAG repeat expansion, a key driver of HD pathogenesis. The position will suit someone with an interest in DNA repair, Huntington's disease, Cryo-electron
microscopy and Structural Mass Spectrometry. </p>
<p class="MsoNormal" style="text-align:justify"><o:p> </o:p></p>
<p class="MsoNormal" style="text-align:justify">You should have a PhD in Structural Biology or a related discipline, with significant experience in single-particle cryoEM, and computational image analysis, data collection and processing, and a strong background
in structural biology. Training in structural mass spectrometry approaches will be provided.
</p>
<p class="MsoNormal" style="text-align:justify"><o:p> </o:p></p>
<p class="MsoNormal" style="text-align:justify">The advert for this post will appear on online soon but in the meantime email Prof. Thalassinos at k.thalassinos@ucl.ac.uk with any queries.</p>
<p class="MsoNormal" style="text-align:justify"><o:p> </o:p></p>
<p class="MsoNormal" style="text-align:justify">References</p>
<p class="MsoNormal" style="text-align:justify"><o:p> </o:p></p>
<p class="MsoNormal" style="text-align:justify">Goold R, et al., FAN1 controls mismatch repair complex assembly via MLH1 retention to stabilize CAG repeat expansion in Huntington's disease. Cell Rep. 2021 Aug 31;36(9):109649. doi: 10.1016/j.celrep.2021.109649.
PMID: 34469738; PMCID: PMC8424649.</p>
<p class="MsoNormal"><span style="font-size:11.0pt"><o:p> </o:p></span></p>
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