<html><head><meta http-equiv="Content-Type" content="text/html; charset=utf-8"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><div class=""><div class=""><div class="" style="margin: 0px; font-stretch: normal; line-height: normal;">Dear colleagues,</div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal;"><br class=""></div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal;">I would like to draw your attention to a 3-year position for a post doc or possibly alternatively a PhD student in my lab in the University of Oulu, Finland. Please pass this information to any suitable candidates you may know.</div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal;"><br class=""></div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal;">Kind regards,</div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal;">Inari</div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal;"><b class=""><br class=""></b></div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal;"><b class="">Post-doctoral (or graduate student) position in structural biology of parasite motility</b></div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal;"><br class=""></div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal;">We are looking for a post-doctoral fellow or possibly a highly-qualified PhD student for a 3-year project (with an option for an extension of one year) in my group at the Faculty of Biochemistry and Molecular Medicine (FBMM), University of Oulu, Finland.</div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal; min-height: 14px;"><br class=""></div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal;">The overall aim of my group is to understand the molecular mechanism of malaria parasite gliding motility. For this, we use a wide variety of structural biology and biochemical/biophysical methods. Our ongoing work is focused on (i) the polymerization and ATPase mechanism of actin, (ii) the structure and function of the glideosome-associated linker protein, and (ii) reconstructing the entire membrane delimited motor complex <i class="">in vitro </i>for structural and functional studies. The exact project will be agreed upon based on the experience and interests of the successful candidate.</div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal; min-height: 14px;"><br class=""></div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal;">The candidate should have either a PhD or MSc in a relevant field of science and have experience or at least a keen interest in all or several of the following:</div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal;">- molecular biology and protein expression and purification</div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal;">- biophysical and biochemical characterization of proteins and their complexes</div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal;">- protein crystallography</div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal;">- electron (cryo) microscopy</div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal;">- light microscopy</div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal; min-height: 14px;"><br class=""></div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal;">We welcome applications particularly from candidates willing and eligible to apply for competitive funding from national, European, and international sources.</div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal; min-height: 14px;"><br class=""></div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal;">Our laboratory is split between the FBMM in Oulu and the Department of Biomedicine, University of Bergen, Norway. Our laboratories and the core facilities available for us have state-of-the-art equipment for molecular biology, protein biochemistry/biophysics, and electron and light microscopy. We have collaborations for cryo-EM and cell biology/parasitology.</div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal; min-height: 14px;"><br class=""></div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal;">The project is funded by the Sigrid Jusélius foundation, and the candidate will receive a personal stipend (tax-exempt up to the limit defined by the Finnish tax authorities).</div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal; min-height: 14px;"><br class=""></div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal;">Informal inquiries and applications including a motivation letter, a CV, and contact information for 2-3 referees are to be sent to <a href="mailto:inari.kursula@oulu.fi" class="">inari.kursula@oulu.fi</a>. Applications will be considered until 15.4.2022 or until a suitable candidate has been identified. The starting date is as soon as possible.</div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal; min-height: 14px;"><br class=""></div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal;">Publications most relevant for the project:</div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal; min-height: 14px;"><br class=""></div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal;"><span class="" style="-webkit-font-kerning: none;">Vahokoski J, Calder L, Lopez AJ, Molloy JE, Kursula I & Rosenthal PB (2022) High-resolution structures of malaria parasite actomyosin and actin filaments. <b class=""><i class="">PLoS Pathog</i></b> in press. Preprint version available in <i class="">bioRxiv</i>: <a href="https://urldefense.proofpoint.com/v2/url?u=https-3A__doi.org_10.1101_2020.07.02.183871&d=DwMFaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=FdU4dvj07cp9-YpRxUC0h5gXZSuqZ_L9JW3OQTbGIS0ZmLh5altfRsGCq9gHGtX5&s=8kaG9G0xzGdlUHyhTeWo-Tw4bLoIqy5gyJFPW09XvmM&e=" class=""><span class="" style="-webkit-font-kerning: none;">https://doi.org/10.1101/2020.07.02.183871</span></a></span></div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal; min-height: 14px;"><span class="" style="text-decoration: underline; -webkit-font-kerning: none;"></span><br class=""></div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal;"><span class="" style="-webkit-font-kerning: none;">Kumpula EP, Lopez AJ, Tajedin L, Han H & Kursula I (2020) Atomic view into <i class="">Plasmodium</i> actin polymerization, ATP hydrolysis, and fragmentation. <b class=""><i class="">PLoS Biol</i></b> 17: e3000315.</span></div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal; min-height: 14px;"><br class=""></div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal;"><span class="" style="-webkit-font-kerning: none;">Kumpula EP, Pires IP, Lasiwa D, Piirainen H, Bergmann U, Vahokoski J & Kursula I (2017) Apicomplexan actin polymerization depends on nucleation. <b class=""><i class="">Sci Rep</i></b> 7: 12137.</span></div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal; min-height: 14px;"><span class="" style="-webkit-font-kerning: none;"></span><br class=""></div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal;"><span class="" style="-webkit-font-kerning: none;">Pospich S, Kumpula EP, von der Ecken J, Vahokoski J, Kursula I & Raunser S (2017) Near-atomic structure of jasplakinolide-stabilized malaria parasite F-actin reveals the structural basis of filament instability. <b class=""><i class="">Proc Natl Acad Sci USA</i></b> 114: 10636-10641.</span></div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal; min-height: 14px;"><span class="" style="-webkit-font-kerning: none;"></span><br class=""></div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal;"><span class="" style="-webkit-font-kerning: none;">Jacot D, Tosetti N, Pires IP, Stock J, Graindorge A, Hung YF, Han H, Tewari R, Kursula I & Soldati-Favre D (2016) An apicomplexan actin-binding protein serves as a connector and lipid sensor to coordinate motility and invasion. <b class=""><i class="">Cell Host Micr</i>o<i class="">be</i></b> 20: 731-743.</span></div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal; min-height: 14px;"><span class="" style="-webkit-font-kerning: none;"></span><br class=""></div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal;">Group webpages: <a href="https://urldefense.proofpoint.com/v2/url?u=https-3A__www.oulu.fi_en_research-2Dgroups_molecular-2Dmechanisms-2Dparasite-2Dmotility&d=DwMFaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=FdU4dvj07cp9-YpRxUC0h5gXZSuqZ_L9JW3OQTbGIS0ZmLh5altfRsGCq9gHGtX5&s=QkLly0Mk0kcoi0Hzxe_Ly-FiUzlJdhJAaoKbKW0lqtQ&e=" class="">https://www.oulu.fi/en/research-groups/molecular-mechanisms-parasite-motility</a>, <a href="https://urldefense.proofpoint.com/v2/url?u=https-3A__www.uib.no_en_rg_inari&d=DwMFaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=FdU4dvj07cp9-YpRxUC0h5gXZSuqZ_L9JW3OQTbGIS0ZmLh5altfRsGCq9gHGtX5&s=st8S3EmBvQSETBzLe_mliZOQRhtEXPH4Xmpx91eCjmA&e=" class="">https://www.uib.no/en/rg/inari</a></div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal;">Selected publications: <a href="https://urldefense.proofpoint.com/v2/url?u=https-3A__www.uib.no_en_rg_inari_149298_our-2Dpublications&d=DwMFaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=FdU4dvj07cp9-YpRxUC0h5gXZSuqZ_L9JW3OQTbGIS0ZmLh5altfRsGCq9gHGtX5&s=DGrjawjoouU77sgZIl0Q0Btqgf-VkPHNDesWV5tRIKs&e=" class="">https://www.uib.no/en/rg/inari/149298/our-publications</a></div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal;">FBMM Oulu: <a href="https://urldefense.proofpoint.com/v2/url?u=https-3A__www.oulu.fi_en_university_faculties-2Dand-2Dunits_faculty-2Dbiochemistry-2Dand-2Dmolecular-2Dmedicine&d=DwMFaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=FdU4dvj07cp9-YpRxUC0h5gXZSuqZ_L9JW3OQTbGIS0ZmLh5altfRsGCq9gHGtX5&s=Tb9iNqXgd4TG1tO7aZFPrJOcdUovccsNu0MqM9GoduQ&e=" class="">https://www.oulu.fi/en/university/faculties-and-units/faculty-biochemistry-and-molecular-medicine</a></div></div><div class="" style="margin: 0px; font-stretch: normal; line-height: normal;"><br class=""></div></div><br class=""><div class="">
--------------------------------------------------------------------------------------<br class="">Prof. Inari Kursula<br class=""><br class="">Department of Biomedicine<br class="">University of Bergen<br class="">Jonas Lies vei 91<br class="">5009 Bergen<br class="">Norway<br class=""><br class="">Faculty of Biochemistry and Molecular Medicine<br class="">University of Oulu<br class="">Aapistie 7<br class="">90220 Oulu<br class="">Finland<br class=""><br class=""><a href="https://urldefense.proofpoint.com/v2/url?u=https-3A__www.uib.no_rg_inari&d=DwMFaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=FdU4dvj07cp9-YpRxUC0h5gXZSuqZ_L9JW3OQTbGIS0ZmLh5altfRsGCq9gHGtX5&s=ae1KqJC7GIx_vlNgfUIDvItWZf6u-_kLiIKk-BQndks&e=" class="">https://www.uib.no/rg/inari</a><br class=""><a href="https://urldefense.proofpoint.com/v2/url?u=https-3A__www.oulu.fi_en_research-2Dgroups_molecular-2Dmechanisms-2Dparasite-2Dmotility&d=DwQFaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=FdU4dvj07cp9-YpRxUC0h5gXZSuqZ_L9JW3OQTbGIS0ZmLh5altfRsGCq9gHGtX5&s=QkLly0Mk0kcoi0Hzxe_Ly-FiUzlJdhJAaoKbKW0lqtQ&e=">https://www.oulu.fi/en/research-groups/molecular-mechanisms-parasite-motility</a><br class="">inari.kursula@uib.no, inari.kursula@oulu.fi<br class=""><br class="">Office in Bergen: https://link.mazemap.com/OtQ8q8bm<br class="">--------------------------------------------------------------------------------------
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