<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title></title>
</head>
<body>
<div name="messageBodySection">
<div dir="auto"><span style="color:black;font-size: 11pt">Dear Researchers, </span><span style="font-size: 11pt"><br /></span><span style="color:black;font-size: 11pt"> </span><span style="font-size: 11pt"><br /></span><span style="color:black;font-size: 11pt">The </span><a style="font-size: 11pt" href="https://urldefense.proofpoint.com/v2/url?u=https-3A__www.bnl.gov_cryo-2Dem_&d=DwMFaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=uElSJtOh44N9t9owbm6VqmO8WYtDDvWK0nc0PZa_V1jlNp8GNuCs5wX8e40gV7Du&s=XH4rFpaY8SR9PxUpzIglFixRgRwb35gljSM25O1e2zc&e=" target="_blank">Laboratory for BioMolecular Structure (LBMS)</a><span style="color:black;font-size: 11pt"> at Brookhaven National Laboratory is now accepting general research proposals through an open proposal process for the July – December (2022-2) cycle. The deadline is </span><strong style="color:red;font-size: 11pt">Tuesday, March 15, 2022 at 11:59 pm New York time</strong><span style="color:black;font-size: 11pt">. </span><span style="font-size: 11pt"><br /></span><span style="color:black;font-size: 11pt"> </span><span style="font-size: 11pt"><br /></span><span style="color:black;font-size: 11pt">This new, state-of-the-art research center offers scientists access to </span><a style="font-size: 11pt" href="https://urldefense.proofpoint.com/v2/url?u=https-3A__www.bnl.gov_cryo-2Dem_instrumentation.php&d=DwMFaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=uElSJtOh44N9t9owbm6VqmO8WYtDDvWK0nc0PZa_V1jlNp8GNuCs5wX8e40gV7Du&s=ZqvG67WbwZ4t5IXxoP5lhY8vxeiVMiDKsdGO9saUcIc&e=" target="_blank">advanced cryo-electron microscopes</a><span style="color:black;font-size: 11pt"> (cryo-EMs) for single particle analysis of proteins and macromolecular complexes, as well as cryo-electron tomography (cryo-ET) of cells and tissues. </span><span style="font-size: 11pt"><br /></span><span style="color:black;font-size: 11pt"> </span><span style="font-size: 11pt"><br /></span><span style="color:black;font-size: 11pt">LBMS operates in two 6-month cycles and all electron microscope (EM) time is requested through the web-based </span><a style="font-size: 11pt" href="https://urldefense.proofpoint.com/v2/url?u=https-3A__pass.bnl.gov_&d=DwMFaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=uElSJtOh44N9t9owbm6VqmO8WYtDDvWK0nc0PZa_V1jlNp8GNuCs5wX8e40gV7Du&s=mgdxvVXeOpEOom_Jw2evCf-j_J-OnzOgb75HupJFpHc&e=" target="_blank">Proposal Allocation, Safety, and Scheduling System (PASS)</a><span style="color:black;font-size: 11pt"> system. There are a number of modes of access for cryo-EMs at LBMS including General User, Rapid Access, and Block Allocation Groups that all follow a common life cycle that involves the following steps: proposal submission, feasibility evaluation, peer-review, allocation of EM time, scheduling, carrying out the work, and reporting the results and publications. </span><span style="font-size: 11pt"><br /></span><span style="color:black;font-size: 11pt"> </span><span style="font-size: 11pt"><br /></span><span style="color:black;font-size: 11pt">To create a new proposal, you need to identify the type of proposal, the technique, and the microscope that fits your needs. For more details, see the </span><a style="font-size: 11pt" href="https://urldefense.proofpoint.com/v2/url?u=https-3A__www.bnl.gov_cryo-2Dem_userguide_&d=DwMFaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=uElSJtOh44N9t9owbm6VqmO8WYtDDvWK0nc0PZa_V1jlNp8GNuCs5wX8e40gV7Du&s=GgDe77NJ_p_G1PNw5_EyRZWiB1n3mu4Mxy15d5pADTY&e=" target="_blank">LBMS User Guide</a><span style="color:black;font-size: 11pt">. </span><strong style="color:black;font-size: 11pt">If you already have an active proposal, you must submit an EM time request (ETR) against that proposal for every cycle that you want EM time through the web-based </strong><a style="font-size: 11pt" href="https://urldefense.proofpoint.com/v2/url?u=https-3A__pass.bnl.gov_&d=DwMFaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=uElSJtOh44N9t9owbm6VqmO8WYtDDvWK0nc0PZa_V1jlNp8GNuCs5wX8e40gV7Du&s=mgdxvVXeOpEOom_Jw2evCf-j_J-OnzOgb75HupJFpHc&e=" target="_blank"><strong>Proposal Allocation, Safety, and Scheduling System</strong></a><strong style="color:black;font-size: 11pt"> (PASS) system</strong><span style="color:black;font-size: 11pt">.</span><span style="font-size: 11pt"><br /></span><span style="color:black;font-size: 11pt"> </span><span style="font-size: 11pt"><br /></span><span style="color:black;font-size: 11pt">If you feel you may need help during the submission process, please create your proposal as early as possible. Please note the </span><a style="font-size: 11pt" href="https://urldefense.proofpoint.com/v2/url?u=https-3A__www.bnl.gov_nsls2_user-2Dservices.php&d=DwMFaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=uElSJtOh44N9t9owbm6VqmO8WYtDDvWK0nc0PZa_V1jlNp8GNuCs5wX8e40gV7Du&s=9kh_mAVk-YU4bt9LZDkf-OS60R8v4Jjobe2UasftcZE&e=" target="_blank">User Services Office</a><span style="color:black;font-size: 11pt"> will be available until 5:00 pm that day. </span><span style="font-size: 11pt"><br /></span><span style="color:black;font-size: 11pt"> </span><span style="font-size: 11pt"><br /></span><span style="color:black;font-size: 11pt">For instructions on how to submit proposals, see the </span><a style="font-size: 11pt" href="https://urldefense.proofpoint.com/v2/url?u=https-3A__www.bnl.gov_cryo-2Dem_userguide_&d=DwMFaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=uElSJtOh44N9t9owbm6VqmO8WYtDDvWK0nc0PZa_V1jlNp8GNuCs5wX8e40gV7Du&s=GgDe77NJ_p_G1PNw5_EyRZWiB1n3mu4Mxy15d5pADTY&e=" target="_blank">LBMS User Guide</a><span style="color:black;font-size: 11pt">. </span><span style="color:#202020;font-size: 11pt">For questions regarding the LBMS facility, please contact Liguo Wang at </span><a style="font-size: 11pt" href="https://urldefense.proofpoint.com/v2/url?u=https-3A__mailto-3Albms-2Dem-40bnl.gov&d=DwMFaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=uElSJtOh44N9t9owbm6VqmO8WYtDDvWK0nc0PZa_V1jlNp8GNuCs5wX8e40gV7Du&s=Qs_E0Ra4AomVvdTp93DwQUYhzZCpzNtfP8TJ3W37vjk&e=" target="_blank">lbms-em@bnl.gov</a><span style="color:#202020;font-size: 11pt">.</span><span style="font-size: 11pt"><br /></span><span style="color:black;font-size: 11pt"> </span><span style="font-size: 11pt"><br /></span><span style="color:black;font-size: 11pt">We look forward to working with you during these exciting early years of LBMS operations!</span><span style="font-size: 11pt"><br /></span><span style="font-size: 11pt"><br /></span>LBMS<br />
Brookhaven National Laboratory </div>
</div>
</body>
</html>