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<h1 style="mso-margin-top-alt:16.2pt;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:15.0pt;vertical-align:baseline">
<span style="font-size:13.0pt;font-family:"Trebuchet MS",sans-serif;color:#00413C;text-transform:uppercase">CORRELATIVE CRYO-ELECTRON TOMOGRAPHY<o:p></o:p></span></h1>
<p class="MsoNormal" style="vertical-align:baseline"><b><span style="font-size:9.0pt;font-family:"Lucida Grande",sans-serif;color:#333333;text-transform:uppercase">NATIONAL HEART LUNG AND BLOOD INSTITUTE, BETHESDA, MD AND SURROUNDING AREA<o:p></o:p></span></b></p>
<h3 style="margin-top:0in;line-height:16.45pt;vertical-align:baseline;outline: 0px">
<strong><span style="font-family:Helvetica;color:#595959;border:none windowtext 1.0pt;padding:0in;font-weight:normal">Position Description:</span></strong><b><span style="font-size:12.5pt;font-family:Helvetica;color:#595959"><o:p></o:p></span></b></h3>
<p class="MsoNormal" style="vertical-align:baseline"><span style="font-family:"Lucida Grande",sans-serif;color:#333333">We are seeking a technically driven postdoctoral fellow to develop and use novel correlative light and electron microscopy (CLEM) methods
for cryo-tomography on mammalian cell plasma membranes. The position is a collaboration between National Heart Lung and Blood Institute (NHLBI) and the National Institute of Diabetes, Digestive, and Kidney Diseases (NIDDK) on the NIH main campus in Bethesda,
Maryland.<o:p></o:p></span></p>
<p class="MsoNormal" style="vertical-align:baseline"><span style="font-family:"Lucida Grande",sans-serif;color:#333333"> <o:p></o:p></span></p>
<p class="MsoNormal" style="vertical-align:baseline"><strong><span style="font-family:"Lucida Grande",sans-serif;color:#333333;border:none windowtext 1.0pt;padding:0in">Who we are</span></strong><span style="font-family:"Lucida Grande",sans-serif;color:#333333">:<o:p></o:p></span></p>
<p class="MsoNormal" style="vertical-align:baseline"><span style="font-family:"Lucida Grande",sans-serif;color:#333333">Three labs, the Taraska, Hinshaw, and Mizuno labs are teaming up to develop a pipeline for correlative cryo-tomography on plasma membranes
complexes. The Taraska Lab (<a href="https://urldefense.proofpoint.com/v2/url?u=https-3A__irp.nih.gov_pi_justin-2Dtaraska&d=DwMGaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=FIE8DmgmXKyftt4nw1kavWdtWAOqY1lM7DHjNqlPRVm1A_qdjlTnJqBFouZP3Xkr&s=JGrJPH4uDgG2peoIObGhuxgYLi7HUBxQ25ejkDZhFF4&e="><span style="color:#357DB4;border:none windowtext 1.0pt;padding:0in">https://irp.nih.gov/pi/justin-taraska</span></a>) uses a variety of advanced imaging methods separately, or in
combination (CLEM) to understand how endocytic and exocytic proteins move and interact with one another at the plasma membrane. The Hinshaw lab (<a href="https://urldefense.proofpoint.com/v2/url?u=https-3A__irp.nih.gov_pi_jenny-2Dhinshaw&d=DwMGaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=FIE8DmgmXKyftt4nw1kavWdtWAOqY1lM7DHjNqlPRVm1A_qdjlTnJqBFouZP3Xkr&s=g5zhn_XcjeWhjhAEPKhFWi9O7EJd0KcYnvCwu5x6N4g&e="><span style="color:#357DB4;border:none windowtext 1.0pt;padding:0in">https://irp.nih.gov/pi/jenny-hinshaw</span></a>)
studies the dynamic structure and function of the dynamin protein family using cryo-electron microscopy and helical reconstruction. The Mizuno lab (<a href="https://urldefense.proofpoint.com/v2/url?u=https-3A__www.nhlbi.nih.gov_science_laboratory-2Dstructural-2Dcell-2Dbiology&d=DwMGaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=FIE8DmgmXKyftt4nw1kavWdtWAOqY1lM7DHjNqlPRVm1A_qdjlTnJqBFouZP3Xkr&s=M1TtIf7l3a_UkTjWeLbISaUcOo3j16sw42H5zxe-rU4&e="><span style="color:#357DB4;border:none windowtext 1.0pt;padding:0in">https://www.nhlbi.nih.gov/science/laboratory-structural-cell-biology</span></a>)
utilizes single particle cryo electron microscopy and cellular tomography to study the cellular cytoskeleton and how it functions to control specialized cell shape in neurons, immune cells, or cancer.
<o:p></o:p></span></p>
<p class="MsoNormal" style="vertical-align:baseline"><span style="font-family:"Lucida Grande",sans-serif;color:#333333"><o:p> </o:p></span></p>
<p class="MsoNormal" style="vertical-align:baseline"><span style="font-family:"Lucida Grande",sans-serif;color:#333333">Together, the trio of labs has been awarded a grant from the Chan-Zuckerberg Initiative (<a href="https://urldefense.proofpoint.com/v2/url?u=https-3A__chanzuckerberg.com_science_programs-2Dresources_imaging_frontiers_correlative-2Dcryo-2Delectron-2Dtomography-2Dpipeline-2Dof-2Dplasma-2Dmembrane-2Dcomplexes_&d=DwMGaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=FIE8DmgmXKyftt4nw1kavWdtWAOqY1lM7DHjNqlPRVm1A_qdjlTnJqBFouZP3Xkr&s=e6pLKKa72rxtDM0-JEqG77Vk2ZZp9A6X0Tlr10aELPU&e="><span style="color:#357DB4;border:none windowtext 1.0pt;padding:0in">https://chanzuckerberg.com/science/programs-resources/imaging/frontiers/correlative-cryo-electron-tomography-pipeline-of-plasma-membrane-complexes/</span></a>)
to develop a correlative cryoET pipeline focused on solving the structures of plasma membrane proteins. This position will be a part of this interactive and dynamic initiative.<o:p></o:p></span></p>
<p class="MsoNormal" style="vertical-align:baseline"><span style="font-family:"Lucida Grande",sans-serif;color:#333333"> <o:p></o:p></span></p>
<p class="MsoNormal" style="vertical-align:baseline"><span style="font-family:"Lucida Grande",sans-serif;color:#333333">The labs have excellent resources for cryo-electron microscopy, cryo-electron tomography, and fluorescent microscopy. NIH Bethesda main
campus has diverse laboratories and expertise as well as excellent research and clinical seminars, providing a superb and stimulating scientific environment that greatly enhances the postdoctoral training experience.<o:p></o:p></span></p>
<p class="MsoNormal" style="vertical-align:baseline"><span style="font-family:"Lucida Grande",sans-serif;color:#333333"> <o:p></o:p></span></p>
<p class="MsoNormal" style="vertical-align:baseline"><strong><span style="font-family:"Lucida Grande",sans-serif;color:#333333;border:none windowtext 1.0pt;padding:0in">Who we are seeking</span></strong><span style="font-family:"Lucida Grande",sans-serif;color:#333333">:<o:p></o:p></span></p>
<p class="MsoNormal" style="vertical-align:baseline"><span style="font-family:"Lucida Grande",sans-serif;color:#333333">If you enjoy creative and novel methods development, team-science, love microscopes and machines, and have a background or interest in quantitative
data analysis, please apply. <o:p></o:p></span></p>
<p class="MsoNormal" style="vertical-align:baseline"><span style="font-family:"Lucida Grande",sans-serif;color:#333333"> <o:p></o:p></span></p>
<h3 style="margin-top:0in;line-height:16.45pt;vertical-align:baseline;outline: 0px">
<strong><span style="font-family:Helvetica;color:#595959;border:none windowtext 1.0pt;padding:0in;font-weight:normal">To Apply</span></strong><span style="font-size:12.5pt;font-family:Helvetica;color:#595959">:<o:p></o:p></span></h3>
<p class="MsoNormal" style="vertical-align:baseline"><span style="font-family:"Lucida Grande",sans-serif;color:#333333">Please submit your CV, bibliography, a brief statement of research interests, and the names of 2 to 3 references to:
<b>Dr. Kem Sochacki</b>, <b>kem.sochacki@nih.gov<o:p></o:p></b></span></p>
<p class="MsoNormal" style="vertical-align:baseline"><span style="font-family:"Lucida Grande",sans-serif;color:#333333"> <o:p></o:p></span></p>
<p class="MsoNormal" style="vertical-align:baseline"><span style="font-family:"Lucida Grande",sans-serif;color:#333333">The deadline for this application is <strong><span style="font-family:"Lucida Grande",sans-serif;border:none windowtext 1.0pt;padding:0in">December
31, 2021</span></strong>. Applications will be considered as they are received.<o:p></o:p></span></p>
<p class="MsoNormal" style="vertical-align:baseline"><span style="font-family:"Lucida Grande",sans-serif;color:#333333"> <o:p></o:p></span></p>
<p class="MsoNormal" style="vertical-align:baseline"><span style="font-family:"Lucida Grande",sans-serif;color:#333333"> <o:p></o:p></span></p>
<p class="MsoNormal" style="vertical-align:baseline"><em><span style="font-family:"Lucida Grande",sans-serif;color:#333333;border:none windowtext 1.0pt;padding:0in">The NIH is dedicated to building a diverse community in its training and employment programs.</span></em><span style="font-family:"Lucida Grande",sans-serif;color:#333333"><o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:.5in;vertical-align:baseline"><span style="font-family:"Lucida Grande",sans-serif;color:#333333"><o:p> </o:p></span></p>
<p align="center" style="text-align:center"><o:p> </o:p></p>
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