<div dir="ltr"><font face="arial, sans-serif">Dear colleagues,</font><div><span style="font-family:arial,sans-serif"><br></span></div><div><span style="font-family:arial,sans-serif">A postdoc position is available immediately at the University of British Columbia.</span><div><div><p class="MsoNormal" style="margin:0cm;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><span style="color:black"><font face="arial, sans-serif"><br></font></span></p><p class="MsoNormal" style="margin:0cm;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><span style="color:black"><font face="arial, sans-serif">The project combines X-ray crystallography, cryo-EM, and electrophysiology. Our lab has steady access to the in-house X-ray and cryo-EM facilities: </font></span></p><p class="MsoNormal" style="margin:0cm;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="arial, sans-serif"> </font></p><p class="MsoNormal" style="margin:0cm;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><span style="color:black"><font face="arial, sans-serif">- Microscopes: 300kV Titan Krios with Falcon IV detector and Selectris Energy filter.   A 200kV Glacios (Falcon III detector) is available for prescreening grids</font></span></p><p class="MsoNormal" style="margin:0cm;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><br></p><p class="MsoNormal" style="margin:0cm;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><span style="color:black"><font face="arial, sans-serif">- X-ray equipment in the lab includes Mosquito and Dragonfly robotics, and we have regular access to an in-house X-ray diffractor (Rigaku Micromax-007 HF with Saturn 744+ CCD detector) and various synchrotron beamlines</font></span></p><p class="MsoNormal" style="margin:0cm;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="arial, sans-serif"> </font></p><p class="MsoNormal" style="margin:0cm;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><span style="color:black"><font face="arial, sans-serif">Minimum requirements for applicants include a PhD in Biochemistry or a related discipline with extensive experience in either X-ray crystallography or cryo-EM, as well as protein expression and purification.  Direct experience with membrane proteins is an additional plus.</font></span></p><p class="MsoNormal" style="margin:0cm;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="arial, sans-serif"> </font></p><p class="MsoNormal" style="margin:0cm;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><span style="color:black"><font face="arial, sans-serif">The lab values diversity and inclusivity, and applicants from all backgrounds are encouraged to apply. This is an opportunity for people with structural biology expertise to learn electrophysiological methods.</font></span></p><p class="MsoNormal" style="margin:0cm;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="arial, sans-serif"> </font></p><p class="MsoNormal" style="margin:0cm;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><span style="color:black"><font face="arial, sans-serif">Recent work from the lab includes an investigation of how Ryanodine Receptors are modulated by small molecules, disease mutations, and post-translational modification, using cryo-EM, X-ray crystallography, planar lipid bilayer electrophysiology, and enzyme kinetics.</font></span></p><p class="MsoNormal" style="margin:0cm;line-height:15.6933px"><font face="arial, sans-serif"><a name="m_7468487004908678465__Hlk73805553"><span lang="EN-US" style="line-height:17.12px;color:black;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">Woll et al (2021) <i>Nature Comm.</i> 12:807</span></a><span lang="EN-US" style="line-height:17.12px;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"></span></font></p><p class="MsoNormal" style="margin:0cm;line-height:15.6933px"><font face="arial, sans-serif"><a name="m_7468487004908678465__Hlk73805545"><span lang="EN-US" style="line-height:17.12px;color:black;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">Ma et al (2020) <i>Nat Chem Biol</i>. 16,1246-1254</span></a><span lang="EN-US" style="line-height:17.12px;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"></span></font></p><p class="MsoNormal" style="margin:0cm;line-height:15.6933px"><font face="arial, sans-serif"><span lang="EN-US" style="line-height:17.12px;color:black;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">Haji-Ghassemi et al (2019) <i>Molecular Cell</i> 75,1-14</span><b><span lang="EN-US" style="line-height:17.12px;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"></span></b></font></p><p class="MsoNormal" style="margin:0cm 0cm 8pt;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><b><span lang="EN-US" style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="arial, sans-serif"> </font></span></b></p><p class="MsoNormal" style="margin:0cm 0cm 8pt;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="arial, sans-serif"><span style="color:black">For more information on recent work, see <a href="https://urldefense.proofpoint.com/v2/url?u=http-3A__crg.ubc.ca_VanPetegem_&d=DwMFaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=61ykktPa_QBQUND8jLui3nRdJTFgFKkkesbIsUYZ4WuT5XkYQDle6N-BmCad-QWB&s=n5QHHrtyCOWDW5-t4Ozz9NQmDh4-WErkw_9uj4PKiXM&e=" target="_blank" style="color:blue"><span style="color:black">http://crg.ubc.ca/VanPetegem/</span></a></span><b><span lang="EN-US" style="background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"></span></b></font></p><p class="MsoNormal" style="margin:0cm;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="arial, sans-serif"> </font></p><p class="MsoNormal" style="margin:0cm;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="arial, sans-serif"><span style="color:black">The lab is housed within the Life Sciences Centre at UBC (<a href="https://urldefense.proofpoint.com/v2/url?u=http-3A__lsi.ubc.ca_&d=DwMFaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=61ykktPa_QBQUND8jLui3nRdJTFgFKkkesbIsUYZ4WuT5XkYQDle6N-BmCad-QWB&s=T5s2lCt6gf52XYlGlWdEwiyZ0V6OPcm0mT6oSC0Rqks&e=" target="_blank">lsi.ubc.ca</a>), located on the Point Grey campus in <span class="gmail-il">Vancouver</span>.</span></font></p><p class="MsoNormal" style="margin:0cm;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="arial, sans-serif"> </font></p><p class="MsoNormal" style="margin:0cm;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="arial, sans-serif"><span style="color:black">Interested candidates should send a CV, along with names and contact details for 3 references to <u><a href="mailto:filip.vanpetegem@gmail.com" target="_blank" style="color:blue"><span style="color:black">filip.vanpetegem@gmail.com</span></a></u>.</span></font></p><p class="MsoNormal" style="margin:0cm;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"><font face="arial, sans-serif"> </font></p></div></div></div><div><br></div>-- <br><div dir="ltr" class="gmail_signature" data-smartmail="gmail_signature"><div dir="ltr"><div>Filip Van Petegem, PhD</div><div>Professor, Dept. of Biochemistry and Molecular Biology<br>The University of British Columbia<br>2350 Health Sciences Mall - Rm 2.356<br>Vancouver, V6T 1Z3<br><br>phone: +1 604 827 4267<br>email: <a href="mailto:filip.vanpetegem@gmail.com" target="_blank">filip.vanpetegem@gmail.com</a><br><a href="https://urldefense.proofpoint.com/v2/url?u=http-3A__crg.ubc.ca_VanPetegem_&d=DwMFaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=61ykktPa_QBQUND8jLui3nRdJTFgFKkkesbIsUYZ4WuT5XkYQDle6N-BmCad-QWB&s=n5QHHrtyCOWDW5-t4Ozz9NQmDh4-WErkw_9uj4PKiXM&e=" target="_blank">http://crg.ubc.ca/VanPetegem/</a></div><div><br></div><div>Twitter: @FilipPetegem</div></div></div></div>