<div dir="ltr"><div dir="ltr"><div dir="ltr"><p class="MsoNormal">Two postdoc positions are currently available in the
Laboratory of Membrane Proteins and Structure Biology in the National Heart,
Lung, and Blood Institute (NHLBI), NIH located in Bethesda, Maryland. The
positions are fully supported by the NHLBI Division of Intramural Research for
up to 5 years, with possibilities of extension and promotion to higher-level
job titles.<span></span></p><p class="MsoNormal"><br></p>

<p class="MsoNormal">Our research is focused on the connections between the
structures, functions, and activity regulations of the membrane proteins that
are involved in important biological processes and/or human diseases. The
recent publications of the lab can be found at <a href="https://urldefense.proofpoint.com/v2/url?u=https-3A__scholar.google.com_citations-3Fhl-3Den-26user-3Dx8zs8D8AAAAJ-26view-5Fop-3Dlist-5Fworks-26sortby-3Dpubdate&d=DwMFaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=bVv3yZWoE2CdDqD5hYwNK9baHfX_x5DKNNcKinunZ7cq_suJdZ8OshnRblMHlNRZ&s=ZcnFoX9Hcwa4QdANcjScLFmoZmEqDfpX1vg7OG2PdGE&e=">https://scholar.google.com/citations?hl=en&user=x8zs8D8AAAAJ&view_op=list_works&sortby=pubdate</a>.
These two new postdoc fellows will join our current research programs and also
create new research directions. Their projects will be focused in two related
directions.<span></span></p>

<p class="MsoNormal">Position 1: high-resolution cryoEM structure determination
and functional characterization of solute carrier (SLC) proteins.<span></span></p>

<p class="MsoNormal">Position 2: structural studies of transporters in the native
membrane using single particle cryoEM and cryoET; method development of
cryoEM data collection and processing.<span></span></p>

<p class="MsoNormal"><br></p><p class="MsoNormal">Candidates with a PhD degree in a related field (biomedical
sciences, physics, chemistry, computer science, etc) are encouraged to apply. Experiences
in structural biology or computer programming are favored but not required. Our
lab and the NIH structural biology community will provide the most rigorous
training on cryoEM and the other skills. <span></span></p>

<p class="MsoNormal"><br></p><p class="MsoNormal">Eligible candidates are also encouraged to apply for the Marshall
W. Nirenberg Fellowship that provides additional career development
opportunities. <a href="https://urldefense.proofpoint.com/v2/url?u=https-3A__www.nhlbi.nih.gov_grants-2Dand-2Dtraining_training-2Dand-2Dcareer-2Ddevelopment_postdoctoral_nirenberg-2Dfellowship&d=DwMFaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=bVv3yZWoE2CdDqD5hYwNK9baHfX_x5DKNNcKinunZ7cq_suJdZ8OshnRblMHlNRZ&s=8F2WFeYDlP0xGz6q1FCiMR8WbIXcincBE0-Oa8WcZ7o&e=">https://www.nhlbi.nih.gov/grants-and-training/training-and-career-development/postdoctoral/nirenberg-fellowship</a><span></span></p>

<p class="MsoNormal"><br></p><p class="MsoNormal">We are in the rapidly growing NIH cryoEM community and have
ample access to the high-end cryoEM instruments hosted in the NIH
Multi-Institute Cryo-EM Facility (MICEF), including a Titan Krios equipped with
GIF and K3, Krios G4 (coming soon), Glacios equipped with Falcon 4, Tecnai F20
equipped with K2, Tecnai 12. The MICEF has recently expanded its capacity on
cryoET and installed new equipment, including Aquilos Cryo-FIB, Leica Cryo
CLEM. To meet different needs for cryo grid preparation, we have access to
different cryo plungers, including Vitrobot Mark IV, Leica EM GP, and a newly
installed Chameleon. The NHLBI core facilities equipped with state-of-the-art
technologies (<a href="https://urldefense.proofpoint.com/v2/url?u=https-3A__www.nhlbi.nih.gov_about_divisions_division-2Dintramural-2Dresearch_dir-2Dcore-2Dfacilities&d=DwMFaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=bVv3yZWoE2CdDqD5hYwNK9baHfX_x5DKNNcKinunZ7cq_suJdZ8OshnRblMHlNRZ&s=hRHd8GEnvJcjGnalRbYMuf0zXeMJdXTLhvZSUe1_334&e=">https://www.nhlbi.nih.gov/about/divisions/division-intramural-research/dir-core-facilities</a>)
provide wonderful supports for our research needs. We have access to a cell
culture facility that grows bacteria, yeasts, and suspension mammalian cells in
large scales to produce membrane proteins. Last, we have an in-house GPU
computer cluster as well as access to the NIH Biowulf super computers for
cryoEM data processing and new data processing method development.<span></span></p>

<p class="MsoNormal"><br></p><p class="MsoNormal">Interested candidates please contact Jiansen Jiang at <a href="mailto:jiansen.jiang@nih.gov">jiansen.jiang@nih.gov</a> with a CV and
names of three referees.<span></span></p><p class="MsoNormal"><br></p><p class="MsoNormal">-----</p><p class="MsoNormal">Jiansen Jiang, Ph.D.</p><p class="MsoNormal">Investigator</p><p class="MsoNormal">Biochemistry and Biophysics Center</p><p class="MsoNormal">National Heart, Lung, and Blood Institute</p><p class="MsoNormal">National Institutes of Health</p><p class="MsoNormal"><br></p><p class="MsoNormal">50 South Drive</p><p class="MsoNormal">Building 50 Room 2152</p><p class="MsoNormal">Bethesda, MD 20892-8012</p><p class="MsoNormal">Tel: 301-827-1698</p><p class="MsoNormal">Email: <a href="mailto:jiansen.jiang@nih.gov">jiansen.jiang@nih.gov</a></p><p class="MsoNormal"><a href="https://urldefense.proofpoint.com/v2/url?u=https-3A__www.nhlbi.nih.gov_science_laboratory-2Dmembrane-2Dproteins-2Dand-2Dstructural-2Dbiology&d=DwMFaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=bVv3yZWoE2CdDqD5hYwNK9baHfX_x5DKNNcKinunZ7cq_suJdZ8OshnRblMHlNRZ&s=hJug1VE86WXr2Ju0p0wkoNOM5GLKuNyhLuM3dJ6Xi8w&e=">https://www.nhlbi.nih.gov/science/laboratory-membrane-proteins-and-structural-biology</a></p><p class="MsoNormal"><br></p></div></div></div>