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<p class="MsoNormal"><span lang="EN-GB" style="font-size:12.0pt">The structural biochemistry group of Piet Gros currently has a vacancy for a postdoctoral researcher to perform cryo-EM studies of large protein complexes involved in cellular immunity. The group
has a long-standing track record at the frontiers of structural biology focusing on elucidating the molecular mechanisms that underlie biological processes with a major emphasis on human plasma-proteins and cell-surface receptors. The lab has an internationally
strong reputation in uncovering the molecular mechanisms that underpin the complement system. We combine protein crystallography, cryo-electron microscopy, light microscopy, biochemical and biophysical assays to get a detailed picture of the molecular interactions
that enable the complement system to discriminate between healthy self-cells and pathogens or dying/malignant cells.
<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB" style="font-size:12.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB" style="font-size:12.0pt">We currently offer the opportunity for a postdoctoral Researcher to join forces with us on an ERC funded project that investigates the correlation between levels of organisation within the membrane
and complement efficacy. Most of the interactions we are looking into for this project are in the high nM to mM range and involve large flexible multi-domain proteins. So, the challenge for you will be to find conditions/tricks that capture the complex of
interest in a state that enables detailed structural analyses. <o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB" style="font-size:12.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB" style="font-size:12.0pt">We seek a highly motivated individual with a PhD in structural biology or a related field and proven experience in cryo-EM. To see the full advert and to apply please follow the link below to
the university vacancy pages:<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB" style="font-size:12.0pt"><a href="https://urldefense.proofpoint.com/v2/url?u=https-3A__www.uu.nl_en_organisation_working-2Dat-2Dutrecht-2Duniversity_jobs_postdoctoral-2Dresearcher-2Dfor-2Dcryo-2Dem-2Dstudies-2Dof-2Dlarge-2Dprotein-2Dcomplexes-2Dinvolved-2Din-2Dcellular-2Dimmunity&d=DwMFAg&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=BoZ571Wm_7wX8V8uC-T41WuRPkwWmFcFyeVtTTWB3dI&s=p78nUhIrXLuflyAjktA0fveQNLiEjB5Hwa-B0Rq8XtY&e=">https://www.uu.nl/en/organisation/working-at-utrecht-university/jobs/postdoctoral-researcher-for-cryo-em-studies-of-large-protein-complexes-involved-in-cellular-immunity</a><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB" style="font-size:12.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB" style="font-size:12.0pt">Deadline for application is October 3<sup>rd</sup> 2021. For more information about the position please email Harma Brondijk:
<a href="mailto:t.h.c.brondijk@uu.nl">t.h.c.brondijk@uu.nl</a> <o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB" style="font-size:12.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB" style="font-size:12.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB" style="font-size:12.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB" style="font-size:12.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB" style="font-size:12.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB" style="font-size:12.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-autospace:none"><b><span style="font-size:8.0pt;font-family:"Verdana",sans-serif;color:gray;mso-fareast-language:NL">Dr. T.H.C. Brondijk</span></b><span style="font-size:8.0pt;font-family:"Verdana",sans-serif;color:#C20033;mso-fareast-language:NL"> |</span><span style="font-size:8.0pt;font-family:"Verdana",sans-serif;color:gray;mso-fareast-language:NL"> Research
Coordinator </span><span style="font-size:8.0pt;font-family:"Verdana",sans-serif;color:#C20033;mso-fareast-language:NL">|</span><span style="font-size:8.0pt;font-family:"Verdana",sans-serif;color:gray;mso-fareast-language:NL"> Structural Biochemistry
</span><span style="font-size:8.0pt;font-family:"Verdana",sans-serif;color:#C20033;mso-fareast-language:NL">|</span><span style="font-size:8.0pt;font-family:"Verdana",sans-serif;color:gray;mso-fareast-language:NL"> Faculty of Science
</span><span style="font-size:8.0pt;font-family:"Verdana",sans-serif;color:#C20033;mso-fareast-language:NL">|</span><span style="font-size:8.0pt;font-family:"Verdana",sans-serif;color:gray;mso-fareast-language:NL"> Utrecht University
</span><span style="font-size:8.0pt;font-family:"Verdana",sans-serif;color:#C20033;mso-fareast-language:NL">|</span><span style="font-size:8.0pt;font-family:"Verdana",sans-serif;color:gray;mso-fareast-language:NL"> David de Wied building, Room 2.35
</span><span lang="EN-GB" style="font-size:8.0pt;font-family:"Verdana",sans-serif;color:#C20033;mso-fareast-language:NL">|
</span><span lang="EN-GB" style="font-size:8.0pt;font-family:"Verdana",sans-serif;color:gray;mso-fareast-language:NL">Universiteitsweg 99, 3584 CG Utrecht </span><span lang="EN-GB" style="font-size:8.0pt;font-family:"Verdana",sans-serif;color:#C20033;mso-fareast-language:NL">||</span><span lang="EN-GB" style="font-size:8.0pt;font-family:"Verdana",sans-serif;color:gray;mso-fareast-language:NL"> </span><span lang="EN-GB" style="font-size:8.0pt;font-family:"Verdana",sans-serif;mso-fareast-language:NL"><a href="mailto:t.h.c.brondijk@uu.nl"><span style="color:blue">t.h.c.brondijk@uu.nl</span></a><span style="color:#C20033">
| </span><span style="color:gray">Aanwezig: ma-vrij</span><o:p></o:p></span></p>
<p class="MsoNormal"><o:p> </o:p></p>
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