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<p class="MsoNormal">Dear All<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><span lang="EN-US">I would like to draw your attention to a vacancy for a postdoctoral researcher in the lab of Piet Gros at Utrecht University, The Netherlands. To read the full text of the vacancy and to apply please follow this
<a href="https://urldefense.proofpoint.com/v2/url?u=https-3A__www.uu.nl_en_organisation_working-2Dat-2Dutrecht-2Duniversity_jobs_postdoctoral-2Dresearcher-2Dfor-2Dcryo-2Dem-2Dstudies-2Dof-2Dlarge-2Dprotein-2Dcomplexes-2Dinvolved-2Din-2Dcellular-2Dimmunity&d=DwMFAg&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=-26UckAPvUpXiVSILj--EB5MBH8K8u8KybZ1oZ5SsoI&s=6WQsRkxtBSlLoI9alM90Uj0upcjqoxry5desM1d7EX4&e=">
link</a> to the Utrecht University vacancy pages. Applications can be made until September 19<sup>th</sup>.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal" style="margin-bottom:3.75pt;background:white"><b><span lang="EN-US" style="font-size:18.0pt;font-family:"Open Sans",sans-serif;color:#3B3B3B;mso-fareast-language:NL">Postdoctoral Researcher for cryo-EM studies of large protein complexes
involved in cellular immunity.<o:p></o:p></span></b></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal" style="line-height:25.5pt;background:white"><span lang="EN-US" style="font-size:12.0pt;font-family:"Merriweather",serif;color:#3B3B3B;mso-fareast-language:NL">The Structural Biochemistry group of Professor Piet Gros has a long-standing
track record at the frontiers of structural biology focusing on elucidating the molecular mechanisms that underlie biological processes with a major emphasis on human plasma-proteins and cell-surface receptors. The lab has an internationally strong reputation
in uncovering the molecular mechanisms that underpin the complement system. We combine protein crystallography, cryo-electron microscopy, light microscopy, biochemical and biophysical assays to get a detailed picture of the molecular interactions that enable
the complement system to discriminate between healthy self-cells and pathogens or dying/malignant cells.<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-top:12.0pt;line-height:25.5pt;background:white">
<span lang="EN-US" style="font-size:12.0pt;font-family:"Merriweather",serif;color:#3B3B3B;mso-fareast-language:NL">We currently offer the opportunity for a postdoctoral Researcher to join forces with us on an ERC funded project that investigates the correlation
between levels of organisation within the membrane and complement efficacy. Most of the interactions we are looking into for this project are in the high nM to mM range and involve large flexible multi-domain proteins. So, the challenge for you will be to
find conditions/tricks that capture the complex of interest in a state that enables detailed structural analyses.<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-top:12.0pt;line-height:25.5pt;background:white">
<span style="font-size:12.0pt;font-family:"Merriweather",serif;color:#3B3B3B;mso-fareast-language:NL">Prinicipal tasks and responsibilities:<o:p></o:p></span></p>
<ul type="disc">
<li class="MsoNormal" style="color:#3B3B3B;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:25.5pt;mso-list:l3 level1 lfo3;background:white">
<span lang="EN-US" style="font-size:12.0pt;font-family:"Merriweather",serif;mso-fareast-language:NL">deliver high quality protein samples for structural analyses;<o:p></o:p></span></li><li class="MsoNormal" style="color:#3B3B3B;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:25.5pt;mso-list:l3 level1 lfo3;background:white">
<span lang="EN-US" style="font-size:12.0pt;font-family:"Merriweather",serif;mso-fareast-language:NL">collect and analyse cryo-EM data;<o:p></o:p></span></li><li class="MsoNormal" style="color:#3B3B3B;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:25.5pt;mso-list:l3 level1 lfo3;background:white">
<span lang="EN-US" style="font-size:12.0pt;font-family:"Merriweather",serif;mso-fareast-language:NL">structure determination, atomic model building and validation;<o:p></o:p></span></li><li class="MsoNormal" style="color:#3B3B3B;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:25.5pt;mso-list:l3 level1 lfo3;background:white">
<span lang="EN-US" style="font-size:12.0pt;font-family:"Merriweather",serif;mso-fareast-language:NL">function as a go-to for PhDs and Postdocs in the group for expert advice on all aspects of cryo-EM sample preparation, data collection and analyses;<o:p></o:p></span></li><li class="MsoNormal" style="color:#3B3B3B;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:25.5pt;mso-list:l3 level1 lfo3;background:white">
<span lang="EN-US" style="font-size:12.0pt;font-family:"Merriweather",serif;mso-fareast-language:NL">communicate you research findings within the group and to the larger scientific community.<o:p></o:p></span></li></ul>
<p class="MsoNormal" style="margin-bottom:3.75pt;background:white"><b><span lang="EN-US" style="font-size:12.0pt;font-family:"Open Sans",sans-serif;color:#3B3B3B;mso-fareast-language:NL">Profile<o:p></o:p></span></b></p>
<p class="MsoNormal" style="line-height:25.5pt;background:white"><span lang="EN-US" style="font-size:12.0pt;font-family:"Merriweather",serif;color:#3B3B3B;mso-fareast-language:NL">We seek a highly motivated individual with the ability to run their project independently,
but who also likes to collaborate with and advice other members of our team.<o:p></o:p></span></p>
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<span style="font-size:12.0pt;font-family:"Merriweather",serif;color:#3B3B3B;mso-fareast-language:NL">Required knowledge/skills/abilities:<o:p></o:p></span></p>
<ul type="disc">
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<span lang="EN-US" style="font-size:12.0pt;font-family:"Merriweather",serif;mso-fareast-language:NL">a PhD in structural biology or a closely related field;<o:p></o:p></span></li><li class="MsoNormal" style="color:#3B3B3B;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:25.5pt;mso-list:l5 level1 lfo6;background:white">
<span style="font-size:12.0pt;font-family:"Merriweather",serif;mso-fareast-language:NL">proven experience in cryo-EM;<o:p></o:p></span></li><li class="MsoNormal" style="color:#3B3B3B;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:25.5pt;mso-list:l5 level1 lfo6;background:white">
<span lang="EN-US" style="font-size:12.0pt;font-family:"Merriweather",serif;mso-fareast-language:NL">purification and analysis of protein complexes;<o:p></o:p></span></li><li class="MsoNormal" style="color:#3B3B3B;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:25.5pt;mso-list:l5 level1 lfo6;background:white">
<span lang="EN-US" style="font-size:12.0pt;font-family:"Merriweather",serif;mso-fareast-language:NL">excellent oral and written skills in English.<o:p></o:p></span></li></ul>
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<b><span lang="EN-US" style="font-size:12.0pt;font-family:"Merriweather",serif;color:#3B3B3B;mso-fareast-language:NL"><br>
</span></b><span lang="EN-US" style="font-size:12.0pt;font-family:"Merriweather",serif;color:#3B3B3B;mso-fareast-language:NL">Optional skills/abilities that are considered an advantage:<o:p></o:p></span></p>
<ul type="disc">
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<span style="font-size:12.0pt;font-family:"Merriweather",serif;mso-fareast-language:NL">protein crystallography;<o:p></o:p></span></li><li class="MsoNormal" style="color:#3B3B3B;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:25.5pt;mso-list:l1 level1 lfo9;background:white">
<span style="font-size:12.0pt;font-family:"Merriweather",serif;mso-fareast-language:NL">Cryo-ET;<o:p></o:p></span></li><li class="MsoNormal" style="color:#3B3B3B;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:25.5pt;mso-list:l1 level1 lfo9;background:white">
<span style="font-size:12.0pt;font-family:"Merriweather",serif;mso-fareast-language:NL">molecular biology;<o:p></o:p></span></li><li class="MsoNormal" style="color:#3B3B3B;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:25.5pt;mso-list:l1 level1 lfo9;background:white">
<span style="font-size:12.0pt;font-family:"Merriweather",serif;mso-fareast-language:NL">handling of membrane proteins.<o:p></o:p></span></li></ul>
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<span style="font-size:13.5pt;font-family:"Merriweather",serif;color:#3B3B3B;mso-fareast-language:NL"><o:p> </o:p></span></p>
<p class="MsoNormal">Harma Brondijk<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal" style="text-autospace:none"><b><span style="font-size:8.0pt;font-family:"Verdana",sans-serif;color:gray;mso-fareast-language:NL"><o:p> </o:p></span></b></p>
<p class="MsoNormal" style="text-autospace:none"><b><span style="font-size:8.0pt;font-family:"Verdana",sans-serif;color:gray;mso-fareast-language:NL">Dr. T.H.C. Brondijk</span></b><span style="font-size:8.0pt;font-family:"Verdana",sans-serif;color:#C20033;mso-fareast-language:NL"> |</span><span style="font-size:8.0pt;font-family:"Verdana",sans-serif;color:gray;mso-fareast-language:NL"> Research
Coordinator </span><span style="font-size:8.0pt;font-family:"Verdana",sans-serif;color:#C20033;mso-fareast-language:NL">|</span><span style="font-size:8.0pt;font-family:"Verdana",sans-serif;color:gray;mso-fareast-language:NL"> Structural Biochemistry
</span><span style="font-size:8.0pt;font-family:"Verdana",sans-serif;color:#C20033;mso-fareast-language:NL">|</span><span style="font-size:8.0pt;font-family:"Verdana",sans-serif;color:gray;mso-fareast-language:NL"> Faculty of Science
</span><span style="font-size:8.0pt;font-family:"Verdana",sans-serif;color:#C20033;mso-fareast-language:NL">|</span><span style="font-size:8.0pt;font-family:"Verdana",sans-serif;color:gray;mso-fareast-language:NL"> Utrecht University
</span><span style="font-size:8.0pt;font-family:"Verdana",sans-serif;color:#C20033;mso-fareast-language:NL">|</span><span style="font-size:8.0pt;font-family:"Verdana",sans-serif;color:gray;mso-fareast-language:NL"> David de Wied building, Room 2.35
</span><span style="font-size:8.0pt;font-family:"Verdana",sans-serif;color:#C20033;mso-fareast-language:NL">|
</span><span style="font-size:8.0pt;font-family:"Verdana",sans-serif;color:gray;mso-fareast-language:NL">Universiteitsweg 99, 3584 CG Utrecht </span><span style="font-size:8.0pt;font-family:"Verdana",sans-serif;color:#C20033;mso-fareast-language:NL">|</span><span style="font-size:8.0pt;font-family:"Verdana",sans-serif;color:gray;mso-fareast-language:NL"> </span><span style="font-size:8.0pt;font-family:"Verdana",sans-serif;color:#C20033;mso-fareast-language:NL">|</span><span style="font-size:8.0pt;font-family:"Verdana",sans-serif;color:gray;mso-fareast-language:NL"> </span><span lang="EN-GB" style="font-size:8.0pt;font-family:"Verdana",sans-serif;mso-fareast-language:NL"><a href="mailto:t.h.c.brondijk@uu.nl"><span lang="NL" style="color:blue">t.h.c.brondijk@uu.nl</span></a></span><span style="font-size:8.0pt;font-family:"Verdana",sans-serif;color:#C20033;mso-fareast-language:NL">
| </span><span style="font-size:8.0pt;font-family:"Verdana",sans-serif;color:gray;mso-fareast-language:NL">Aanwezig: ma-vrij</span><span style="font-size:8.0pt;font-family:"Verdana",sans-serif;mso-fareast-language:NL"><o:p></o:p></span></p>
<p class="MsoNormal"><o:p> </o:p></p>
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<span style="font-size:13.5pt;font-family:"Merriweather",serif;color:#3B3B3B;mso-fareast-language:NL"><o:p> </o:p></span></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
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